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The role of Spongia Sp. In the discovery of marine lead compounds

dc.contributor.authorMaximo, P.
dc.contributor.authorFerreira, Luísa M.
dc.contributor.authorBranco, Paula
dc.contributor.authorLima, Pedro
dc.contributor.authorLourenço, Ana
dc.contributor.institutionLAQV@REQUIMTE
dc.contributor.institutionDQ - Departamento de Química
dc.contributor.institutionNOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
dc.contributor.pblMDPI - Multidisciplinary Digital Publishing Institute
dc.date.accessioned2017-05-27T00:01:10Z
dc.date.available2017-05-27T00:01:10Z
dc.date.issued2016-08-01
dc.descriptionPromar (31-04-01-FEP-308); QREN (2014/39985)
dc.description.abstractA comprehensive review on the chemistry of Spongia sp. is here presented, together with the biological activity of the isolated compounds. The compounds are grouped in sesquiterpene quinones, diterpenes, C21 and other linear furanoterpenes, sesterterpenes, sterols (including secosterols), macrolides and miscellaneous compounds. Among other reports we include studies on the intraspecific diversity of a Mediterranean species, compounds isolated from associated sponge and nudibranch and compounds isolated from S. zimocca and the red seaweed Laurentia microcladia. Under biological activity a table of the reported biological activities of the various compounds and the biological screening of extracts are described. The present review covers the literature from 1971 to 2015.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent33233134
dc.identifier.doi10.3390/md14080139
dc.identifier.otherPURE: 1122256
dc.identifier.otherPURE UUID: 88b2b978-7c98-4472-8585-3004bbd83145
dc.identifier.otherScopus: 84984998279
dc.identifier.otherWOS: 000380763000002
dc.identifier.otherPubMed: 27455286
dc.identifier.otherPubMedCentral: PMC4999901
dc.identifier.urihttp://www.scopus.com/inward/record.url?scp=84984998279&partnerID=8YFLogxK
dc.identifier.urlhttps://www.scopus.com/pages/publications/84984998279
dc.language.isoeng
dc.peerreviewedyes
dc.subjectBiological activity
dc.subjectC21 furanoterpenes
dc.subjectDiterpenes
dc.subjectMacrolides
dc.subjectSesquiterpene quinones
dc.subjectSesterterpenes
dc.subjectSpongia sp.
dc.subjectSterols
dc.subjectDrug Discovery
dc.subjectSDG 14 - Life Below Water
dc.titleThe role of Spongia Sp. In the discovery of marine lead compoundsen
dc.typereview
degois.publication.issue8
degois.publication.titleMarine Drugs
degois.publication.volume14
dspace.entity.typePublication
rcaap.rightsopenAccess

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