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Comparison of the radiosensitisation ability of metal oxide nanoparticles using clinical megavoltage X-rays

2020-07Tese de doutoramento Acesso aberto
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datacite.subject.fosEngenharia e Tecnologia::Outras Engenharias e Tecnologiaspt_PT
dc.contributor.advisorGolding, Jon
dc.contributor.advisorMason, Nigel
dc.contributor.advisorPereira, Maria Alice
dc.contributor.authorGuerreiro, Alexandra Furtado
dc.date.accessioned2020-10-08T15:25:41Z
dc.date.available2020-10-08T15:25:41Z
dc.date.issued2020-07
dc.date.submitted2020
dc.description.abstractA wide range of nanoparticles (NPs), composed of different elements and their compounds, are being developed by several groups as possible radiosensitisers, with some already in clinical trials. However, no systematic experimental survey of the clinical X-ray radiosensitising potential of different element NPs has been made. In this thesis, a direct comparison is made through the irradiation-induced (10 Gy of 6 MeV X-ray photon) production of reactive oxygen species (ROS) such as hydroxyl radicals, superoxide anion radicals and singlet oxygen in aqueous solutions of the different metal oxide NPs. Also, cancer cell and DNA damage due to these NPs is studied under irradiation conditions. The results of this thesis showed that without any X-rays, several NPs produced different radicals. Furthermore, NPs such as vanadium oxide (V2O5) produced a significant amount of radicals compared to water and to the other types of NPs when irradiated with 10 Gy of 6 MeV X-rays and NPs such as copper oxide (CuO) showed significant cell and DNA damage that is not related to the production of ROS. Beyond identifying promising metal oxide NPs radiosensitisers, these results have shown evidence that the chemical and biological effects of these NPs are also present in the mode of action of these radiosensitisers challenging the pure physical radio-enhancement concept.pt_PT
dc.identifier.tid101654448
dc.identifier.urihttp://hdl.handle.net/10362/105275
dc.language.isoengpt_PT
dc.relationPD/00193/2012pt_PT
dc.relationImproving the efficiency and targeting of radiosensitisers
dc.subjectmetal oxide nanoparticlespt_PT
dc.subjectclinical X-raypt_PT
dc.subjectROSpt_PT
dc.subjecthydroxyl and superoxide radicalpt_PT
dc.subjectsinglet oxygenpt_PT
dc.subjectradiosensitiserpt_PT
dc.titleComparison of the radiosensitisation ability of metal oxide nanoparticles using clinical megavoltage X-rayspt_PT
dc.typedoctoral thesis
dspace.entity.typePublication
oaire.awardNumberUID/Multi/04378/2013
oaire.awardNumberUID/FIS/00068/2013
oaire.awardNumberPD/BD/114450/2016
oaire.awardTitleImproving the efficiency and targeting of radiosensitisers
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FMulti%2F04378%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FFIS%2F00068%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//PD%2FBD%2F114450%2F2016/PT
oaire.fundingStream5876
oaire.fundingStream5876
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typedoctoralThesispt_PT
relation.isProjectOfPublicationf6c6102f-c577-4633-a70c-08a0b27e1207
relation.isProjectOfPublication8cef5a46-69a9-42a0-a449-8c44acd9d1ea
relation.isProjectOfPublication8e7c25dd-7f17-4f65-86f0-303d6cf677a1
relation.isProjectOfPublication.latestForDiscovery8e7c25dd-7f17-4f65-86f0-303d6cf677a1
thesis.degree.nameDoctor of Philosophy in Radiation Biology and Biophysicspt_PT

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