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Procedures in Fecal Microbiota Transplantation for Treating Irritable Bowel Syndrome

2023-03Recensão Acesso aberto
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dc.contributor.authorRodrigues, Tânia
dc.contributor.authorRodrigues Fialho, Sofia
dc.contributor.authorAraújo, João Ricardo
dc.contributor.authorRocha, Rita
dc.contributor.authorMoreira-Rosário, André
dc.contributor.institutionCentro de Investigação em Tecnologias e Serviços de Saúde (CINTESIS)
dc.contributor.institutionNOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
dc.contributor.pblMDPI - Multidisciplinary Digital Publishing Institute
dc.date.accessioned2023-04-04T22:17:34Z
dc.date.available2023-04-04T22:17:34Z
dc.date.issued2023-03
dc.descriptionFunding Information: This work was sponsored by national funds through FCT, Fundação para a Ciência e a Tecnologia, I.P., within the scope of the projects CINTESIS, R&D Unit (reference UIDB/4255/2020) and “RISE—LA/P/0053/2020”.
dc.description.abstractBackground: Irritable bowel syndrome (IBS) is a prevalent gastrointestinal disease with no effective treatment. Altered microbiota composition seems implicated in disease etiology and therefore fecal microbial transplantation (FMT) has emerged as a possible treatment therapy. To clarify the clinical parameters impacting FMT efficacy, we conducted a systematic review with subgroup analysis. Methods: A literature search was performed identifying randomized controlled trials (RCTs) comparing FMT with placebo in IBS adult patients (8-week follow-up) with a reported improvement in global IBS symptoms. Results: Seven RCTs (489 participants) met the eligibility requirements. Although FMT seems not to be effective in global improvement of IBS symptoms, subgroup analysis shows that FMT through gastroscopy or nasojejunal tube are effective IBS treatments (RR 3.03; 95% CI 1.94–4.73; I2 = 10%, p < 0.00001). When considering non-oral ingestion routes, IBS patients with constipation symptoms are more likely to benefit from FMT administration (p = 0.003 for the difference between IBS subtypes regarding constipation). Fresh fecal transplant and bowel preparation seem also to have impact on FMT efficacy (p = 0.03 and p = 0.01, respectively). Conclusion: Our meta-analysis revealed a set of critical steps that could affect the efficacy of FMT as clinical procedure to treat IBS, nevertheless more RCTs are needed.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent1347132
dc.identifier.doi10.3390/jcm12051725
dc.identifier.issn2077-0383
dc.identifier.otherPURE: 56482391
dc.identifier.otherPURE UUID: 0d49c9ae-b77d-4e15-b5c9-2eae53cfde49
dc.identifier.otherScopus: 85149995440
dc.identifier.urihttp://hdl.handle.net/10362/151583
dc.identifier.urlhttps://www.scopus.com/pages/publications/85149995440
dc.language.isoeng
dc.peerreviewedyes
dc.subjectfecal microbiota transplantation
dc.subjectirritable bowel syndrome
dc.subjectmeta-analysis
dc.subjectmicrobiome therapy
dc.subjectrandomized controlled trials
dc.subjectGeneral Medicine
dc.titleProcedures in Fecal Microbiota Transplantation for Treating Irritable Bowel Syndromeen
dc.title.subtitleSystematic Review and Meta-Analysisen
dc.typereview
degois.publication.issue5
degois.publication.titleJournal of Clinical Medicine
degois.publication.volume12
dspace.entity.typePublication
rcaap.rightsopenAccess

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