Logo do repositório
 
Publicação

Multidrug-Resistant Salmonella enterica Serovar Rissen Clusters Detected in Azores Archipelago, Portugal

2019Artigo científico Acesso aberto
Ver registo simples
dc.contributor.authorSilveira, Leonor
dc.contributor.authorPinto, Miguel
dc.contributor.authorIsidro, Joana
dc.contributor.authorPista, Ângela
dc.contributor.authorThemudo, Patrícia
dc.contributor.authorVieira, Luís
dc.contributor.authorMachado, Jorge
dc.contributor.authorGomes, João Paulo
dc.contributor.institutionNOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
dc.contributor.institutionCentre for Toxicogenomics and Human Health (ToxOmics)
dc.contributor.pblHindawi Publishing Corporation
dc.date.accessioned2020-01-16T00:07:15Z
dc.date.available2020-01-16T00:07:15Z
dc.date.issued2019
dc.description.abstractGastrointestinal infections caused by nontyphoidal Salmonella (NTS) remain one of the main causes of foodborne illness worldwide. Within the multiple existing Salmonella enterica serovars, the serovar Rissen is rarely reported, particularly as a cause of human salmonellosis. Between 2015 and 2017, the Portuguese National Reference Laboratory of Gastrointestinal Infections observed an increase in the number of clinical cases caused by multidrug-resistant (MDR) S. enterica serovar Rissen, particularly from the Azores archipelago. In the present study, we analyzed by whole genome sequencing (WGS) all clinical, animal, food, and environmental isolates received up to 2017 in the Portuguese Reference Laboratories. As such, through a wgMLST-based gene-by-gene analysis, we aimed to identify potential epidemiological clusters linking clinical and samples from multiple sources, while gaining insight into the genetic diversity of S. enterica serovar Rissen. We also investigated the genetic basis driving the observed multidrug resistance. By integrating 60 novel genomes with all publicly available serovar Rissen genomes, we observed a low degree of genetic diversity within this serovar. Nevertheless, the majority of Portuguese isolates showed high degree of genetic relatedness and a potential link to pork production. An in-depth analysis of these isolates revealed the existence of two major clusters from the Azores archipelago composed of MDR isolates, most of which were resistant to at least five antimicrobials. Considering the well-known spread of MDR between gastrointestinal bacteria, the identification of MDR circulating clones should constitute an alert to public health authorities. Finally, this study constitutes the starting point for the implementation of the "One Health" approach for Salmonella surveillance in Portugal.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent1918210
dc.identifier.doi10.1155/2019/1860275
dc.identifier.issn2314-436X
dc.identifier.otherPURE: 16347205
dc.identifier.otherPURE UUID: 741ea049-ceda-4d7b-a004-20c949e9180e
dc.identifier.otherScopus: 85077449286
dc.identifier.otherWOS: 000521959700001
dc.identifier.urihttp://hdl.handle.net/10362/91269
dc.identifier.urlhttps://www.scopus.com/pages/publications/85077449286
dc.language.isoeng
dc.peerreviewedyes
dc.subjectBiochemistry
dc.subjectMolecular Biology
dc.subjectGenetics
dc.subjectPharmaceutical Science
dc.subjectSDG 3 - Good Health and Well-being
dc.titleMultidrug-Resistant Salmonella enterica Serovar Rissen Clusters Detected in Azores Archipelago, Portugalen
dc.typejournal article
degois.publication.titleInternational Journal of Genomics
degois.publication.volume2019
dspace.entity.typePublication
rcaap.rightsopenAccess

Ficheiros

Principais
A mostrar 1 - 1 de 1
Miniatura
Nome:
1860275.pdf
Tamanho:
1.83 MB
Formato:
Adobe Portable Document Format
Ver/Abrir

Coleções

NMS: ToxOmics - Artigos em revista internacional com arbitragem científica