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PRIMARY-HF

2025-04Artigo científico Acesso aberto
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dc.contributor.authorDos Santos, Jonathan
dc.contributor.authorNobre, João Pedro
dc.contributor.authorFerreira, João Pedro
dc.contributor.authorMarques, Maria Inês M.
dc.contributor.authorHenriques, Miguel
dc.contributor.authorCardim, Nuno
dc.contributor.authorCardim, Nuno
dc.contributor.authorVillanueva, Tiago
dc.contributor.authorGonçalves, Alexandra
dc.contributor.institutionNOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
dc.contributor.pblBiblioteca Nacional de Portugal, Centro de Estudos Históricos, CELOM
dc.date.accessioned2025-04-14T21:12:15Z
dc.date.available2025-04-14T21:12:15Z
dc.date.issued2025-04
dc.descriptionPublisher Copyright: Copyright © Ordem dos Médicos 2025.
dc.description.abstractIntroduction: Heart failure is a major health challenge with high morbidity and socioeconomic burden, especially when diagnosis is delayed. In primary care, HF detection can be challenging due to symptoms overlapping with other conditions, limited access to diagnostic tools, and resource constraints. This study explores the use of natriuretic peptides (NT-proBNP) and point-of-care ultrasound (POCUS) with artificial intelligence integration as tools to improve HF screening and management in primary care. This study aims to determine whether NT-proBNP testing alone or combined with cardiac POCUS improves heart failure diagnosis and management in primary care settings, and to evaluate the cost-effectiveness of this approach. Methods: This randomized controlled trial will involve patients aged 50 or older with suspected HF or cardiovascular risk factors, recruited across four primary care centers. Participants will be randomly assigned to one of four groups: standard of care (SoC), SoC with NT-proBNP, SoC with NT-proBNP and POCUS, and SoC with POCUS. Primary outcomes include new HF diagnosis, initiation of guideline-directed medical therapy, and improvement in health-related quality of life. Secondary outcomes include cost-effectiveness and the quality assessment of POCUS performed by trained primary care physicians. The integration of NT-proBNP and POCUS in primary care may enhance early heart failure diagnosis, optimize therapy, improve patient quality of life, and reduce healthcare costs associated with heart failure misdiagnosis and delayed treatment. This study could support the broader adoption of accessible diagnostic tools to improve heart failure management in primary care.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent8
dc.format.extent440981
dc.identifier.doi10.20344/amp.22463
dc.identifier.issn0870-399X
dc.identifier.otherPURE: 114950472
dc.identifier.otherPURE UUID: 12c6baf4-d7bf-41ae-8a4f-9528532ec87f
dc.identifier.otherScopus: 105001947969
dc.identifier.otherPubMed: 39993148
dc.identifier.urihttp://hdl.handle.net/10362/182285
dc.identifier.urlhttps://www.scopus.com/pages/publications/105001947969
dc.language.isoeng
dc.peerreviewedyes
dc.subjectBiomarkers
dc.subjectEchocardiography
dc.subjectHeart Failure/diagnosis
dc.subjectHeart Failure/diagnostic imaging
dc.subjectNatriuretic Peptide
dc.subjectPoint-of-Care Systems
dc.subjectPrimary Health Care
dc.subjectGeneral Medicine
dc.titlePRIMARY-HFen
dc.title.subtitleHeart Failure Screening in Primary Care using Point-of-Careen
dc.typejournal article
degois.publication.firstPage237
degois.publication.issue4
degois.publication.lastPage244
degois.publication.titleActa Medica Portuguesa
degois.publication.volume38
dspace.entity.typePublication
person.familyNameCardim
person.givenNameNuno
person.identifier.orcid0000-0002-3812-4872
rcaap.rightsopenAccess
relation.isAuthorOfPublicationbcbf3f33-253a-4b76-a55f-23e4caf28001
relation.isAuthorOfPublication.latestForDiscoverybcbf3f33-253a-4b76-a55f-23e4caf28001

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