Logo do repositório
 
Publicação

HBM4EU Chromates Study-Genotoxicity and Oxidative Stress Biomarkers in Workers Exposed to Hexavalent Chromium

2022-08-18Artigo científico Acesso aberto
Ver registo simples
dc.contributor.authorTavares, Ana
dc.contributor.authorAimonen, Kukka
dc.contributor.authorNdaw, Sophie
dc.contributor.authorFučić, Aleksandra
dc.contributor.authorCatalán, Julia
dc.contributor.authorDuca, Radu Corneliu
dc.contributor.authorGodderis, Lode
dc.contributor.authorGomes, Bruno C
dc.contributor.authorJanasik, Beata
dc.contributor.authorLadeira, Carina
dc.contributor.authorLouro, Henriqueta
dc.contributor.authorNamorado, Sónia
dc.contributor.authorNieuwenhuyse, An Van
dc.contributor.authorNorppa, Hannu
dc.contributor.authorScheepers, Paul T J
dc.contributor.authorVentura, Célia
dc.contributor.authorVerdonck, Jelle
dc.contributor.authorViegas, Susana
dc.contributor.authorWasowicz, Wojciech
dc.contributor.authorSantonen, Tiina
dc.contributor.authorSilva, Maria João
dc.contributor.institutionCentre for Toxicogenomics and Human Health (ToxOmics)
dc.contributor.institutionNOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
dc.contributor.institutionComprehensive Health Research Centre (CHRC) - Pólo ENSP
dc.contributor.institutionEscola Nacional de Saúde Pública (ENSP)
dc.contributor.institutionCentro de Investigação em Saúde Pública (CISP/PHRC)
dc.contributor.pblMDPI - Multidisciplinary Digital Publishing Institute
dc.date.accessioned2022-09-09T22:42:06Z
dc.date.available2022-09-09T22:42:06Z
dc.date.issued2022-08-18
dc.descriptionFunding: This project has received funding from the European Union’s Horizon 2020 Research and Innovation Programme under grant agreement no. 733032 and received co-funding from the author’s organizations and/or Ministries.
dc.description.abstractA study was conducted within the European Human Biomonitoring Initiative (HBM4EU) to characterize occupational exposure to Cr(VI). Herein we present the results of biomarkers of genotoxicity and oxidative stress, including micronucleus analysis in lymphocytes and reticulocytes, the comet assay in whole blood, and malondialdehyde and 8-oxo-2'-deoxyguanosine in urine. Workers from several Cr(VI)-related industrial activities and controls from industrial (within company) and non-industrial (outwith company) environments were included. The significantly increased genotoxicity ( p = 0.03 for MN in lymphocytes and reticulocytes; p < 0.001 for comet assay data) and oxidative stress levels ( p = 0.007 and p < 0.001 for MDA and 8-OHdG levels in pre-shift urine samples, respectively) that were detected in the exposed workers over the outwith company controls suggest that Cr(VI) exposure might still represent a health risk, particularly, for chrome painters and electrolytic bath platers, despite the low Cr exposure. The within-company controls displayed DNA and chromosomal damage levels that were comparable to those of the exposed group, highlighting the relevance of considering all industry workers as potentially exposed. The use of effect biomarkers proved their capacity to detect the early biological effects from low Cr(VI) exposure, and to contribute to identifying subgroups that are at higher risk. Overall, this study reinforces the need for further re-evaluation of the occupational exposure limit and better application of protection measures. However, it also raised some additional questions and unexplained inconsistencies that need follow-up studies to be clarified.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent1296843
dc.identifier.doi10.3390/toxics10080483
dc.identifier.issn2305-6304
dc.identifier.otherPURE: 46260069
dc.identifier.otherPURE UUID: d86becf1-c2f0-43e4-b0c5-753f0f35f970
dc.identifier.otherPubMed: 36006162
dc.identifier.otherScopus: 85137317362
dc.identifier.otherWOS: 000845140600001
dc.identifier.urihttp://hdl.handle.net/10362/143633
dc.language.isoeng
dc.peerreviewedyes
dc.subject8-OHdG
dc.subjectbiomonitoring
dc.subjectchromate
dc.subjectcomet assay
dc.subjecteffect biomarkers
dc.subjectMDA
dc.subjectmicronuclei
dc.subjectoccupational exposure
dc.subjectSDG 3 - Good Health and Well-being
dc.titleHBM4EU Chromates Study-Genotoxicity and Oxidative Stress Biomarkers in Workers Exposed to Hexavalent Chromiumen
dc.typejournal article
degois.publication.issue8
degois.publication.titleToxics
degois.publication.volume10
dspace.entity.typePublication
rcaap.rightsopenAccess

Ficheiros

Principais
A mostrar 1 - 1 de 1
Miniatura
Nome:
toxics_10_00483_v3.pdf
Tamanho:
1.24 MB
Formato:
Adobe Portable Document Format
Ver/Abrir

Coleções

NMS: ToxOmics - Artigos em revista internacional com arbitragem científica