Logo do repositório
 
Publicação

Evaluation of the different thresholding strategies for quantifying choriocapillaris using optical coherence tomography angiography

2020-07Artigo científico Acesso aberto
Ver registo simples
dc.contributor.authorLaiginhas, Rita
dc.contributor.authorCabral, Diogo
dc.contributor.authorFalcão, Manuel
dc.contributor.institutionNOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
dc.contributor.pblAME Publishing Company
dc.date.accessioned2020-09-22T22:16:16Z
dc.date.available2020-09-22T22:16:16Z
dc.date.issued2020-07
dc.description.abstractBackground: In this paper, we evaluate the different thresholding strategies that have been used for the quantification of the choriocapillaris (CC) and explore their repeatability and the interchangeability of the measurements resulting from its application. Methods: Observational study. Eighteen eyes from nine healthy volunteers aged >18 years were imaged four consecutive times with a SD-OCTA system (Heidelberg Engineering, Germany) using a 10°×10° high-resolution protocol centered on the fovea. Projection artifacts were removed, and the CC was bracketed between 10 and 30 µm below Bruch’s membrane. For the quantification of CC, we used four flow deficits (FD) parameters: FD number, mean FD size, total FD area and FD density. We performed a systematic review of literature to collect the thresholding methods that have been used for the quantification of CC. The CC quantification parameters were then evaluated after applying each of the thresholding strategies. Intraclass correlation coefficient (ICC) and Pearson’s correlation analysis were used to compare the repeatability and interchangeability among the different thresholding strategies for quantifying the CC. Results: A total of 72 optical coherence tomography angiography (OCTA) examinations were considered. The systematic review allowed us to conclude that three local thresholding strategies (Phansalkar, mean and Niblack) and three global thresholding strategies (mean, default, Otsu) have been used for CC quantification. These strategies were evaluated in our observational study. We found a high agreement within the same method in the quantification of FD number, mean FD size, total FD area and FD density but a poor agreement with different strategies. Local strategies achieved a significantly superior ICC than global ones in CC quantification. Conclusions: In conclusion, the interchangeability of the CC quantification using different thresholding strategies is low, and direct comparisons should not be performed. Local thresholding strategies are significantly superior to global ones for quantifying CC and should be preferred. There is an unmet need for a uniform strategy to quantify CC in future studies.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent12
dc.format.extent1242707
dc.identifier.doi10.21037/QIMS-20-340
dc.identifier.issn2223-4292
dc.identifier.otherPURE: 19944245
dc.identifier.otherPURE UUID: 4ce513f7-19b2-4087-9284-f74ddfffc8c8
dc.identifier.otherScopus: 85090714646
dc.identifier.otherPubMed: 33014731
dc.identifier.otherWOS: 000569098000009
dc.identifier.urihttp://hdl.handle.net/10362/104550
dc.identifier.urlhttps://www.scopus.com/pages/publications/85090714646
dc.language.isoeng
dc.peerreviewedyes
dc.subjectBinarization
dc.subjectChoriocapillaris (CC)
dc.subjectOptical coherence tomography angiography (OCTA)
dc.subjectThresholding
dc.subjectRadiology Nuclear Medicine and imaging
dc.titleEvaluation of the different thresholding strategies for quantifying choriocapillaris using optical coherence tomography angiographyen
dc.typejournal article
degois.publication.firstPage1994
degois.publication.issue10
degois.publication.lastPage2005
degois.publication.titleQuantitative Imaging in Medicine and Surgery
degois.publication.volume10
dspace.entity.typePublication
rcaap.rightsopenAccess

Ficheiros

Principais
A mostrar 1 - 1 de 1
Miniatura
Nome:
qims_10_10_1994.pdf
Tamanho:
1.19 MB
Formato:
Adobe Portable Document Format
Ver/Abrir

Coleções

NMS: CEDOC - Artigos em revista internacional com arbitragem científica