Logo do repositório
 
Publicação

Impact of Treatment Modality on Vascular Function in Coarctation of the Aorta

2019-04-02Artigo científico Acesso aberto
Ver registo simples
dc.contributor.authorMartins, José D.
dc.contributor.authorZachariah, Justin
dc.contributor.authorSelamet Tierney, Elif Seda
dc.contributor.authorTruong, Uyen
dc.contributor.authorMorris, Shaine A.
dc.contributor.authorKutty, Shelby
dc.contributor.authorde Ferranti, Sarah D.
dc.contributor.authorGuarino, Maria
dc.contributor.authorThomas, Boban
dc.contributor.authorOliveira, Diana
dc.contributor.authorMarinho, António
dc.contributor.authorAntónio, Marta
dc.contributor.authorGauvreau, Kimberlee
dc.contributor.authorJalles, Nuno
dc.contributor.authorGeva, Tal
dc.contributor.authorCarmo, Miguel M.
dc.contributor.authorPrakash, Ashwin
dc.contributor.institutionCentro de Estudos de Doenças Crónicas (CEDOC)
dc.contributor.institutionNOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
dc.contributor.pblAmerican Heart Association Inc.
dc.date.accessioned2019-04-29T22:17:26Z
dc.date.available2019-04-29T22:17:26Z
dc.date.issued2019-04-02
dc.description.abstractBackground Optimally treated patients with coarctation of the aorta remain at risk for late vascular dysfunction. The effect of treatment modality on vascular function is unknown. The LOVE-COARCT (Long-term Outcomes and Vascular Evaluation After Successful Coarctation of the Aorta Treatment) study was done to compare vascular function in patients with coarctation of the aorta treated with surgery, balloon dilation (BD), or stent implantation. Methods and Results In treated coarctation of the aorta patients without residual coarctation, we prospectively compared aortic stiffness by applanation tonometry and cardiac magnetic resonance; endothelial function by endothelial pulse amplitude testing; blood pressure ( BP ) phenotype by office BP , ambulatory BP monitoring, and BP response to exercise; left ventricular mass by cardiac magnetic resonance; and blood biomarkers of endothelial function, inflammation, vascular wall function, and extracellular matrix. Participants included 75 patients treated with surgery (n=28), BD (n=23), or stent (n=24). Groups had similar age at enrollment, coarctation of the aorta severity, residual gradient, and metabolic profile, but differed by age at treatment. Prevalence of systemic hypertension, aortic stiffness, endothelial function, and left ventricular mass were similar among treatment groups. However, BD patients had more-distensible ascending aortas, lower peak systolic BP during exercise, less impairment in diurnal BP variation, and lower inflammatory biomarkers. Results were unchanged after adjustment for potential confounders, including age at treatment. Conclusions In our cohort of patients without residual coarctation, treatment modality was not associated with major vascular outcomes, even though there were some favorable vascular characteristics in the BD patients. Although this suggests that choice of treatment modality should continue to be driven by likelihood of achieving a good anatomical result, more long-term studies are required to assess the clinical significance of the more-optimal results of secondary markers of vascular function in BD patients. Clinical Trial Registration URL : http://www.clinicaltrials.gov . Unique identifier: NCT 03262753.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent544352
dc.identifier.doi10.1161/JAHA.118.011536
dc.identifier.issn2047-9980
dc.identifier.otherPURE: 12985439
dc.identifier.otherPURE UUID: 2bc9e1cb-1ddf-42cb-9956-a865b37af867
dc.identifier.otherScopus: 85063993956
dc.identifier.otherPubMed: 30929556
dc.identifier.otherWOS: 000484574300022
dc.identifier.urihttp://www.scopus.com/inward/record.url?scp=85063993956&partnerID=8YFLogxK
dc.identifier.urlhttps://www.scopus.com/pages/publications/85063993956
dc.language.isoeng
dc.peerreviewedyes
dc.subjectarterial stiffness
dc.subjectcoarctation of the aorta
dc.subjectlong‐term outcome
dc.subjectpulse wave velocity
dc.subjectvascular function
dc.subjectCardiology and Cardiovascular Medicine
dc.titleImpact of Treatment Modality on Vascular Function in Coarctation of the Aortaen
dc.title.subtitleThe LOVE - COARCT Studyen
dc.typejournal article
degois.publication.firstPage
degois.publication.issue7
degois.publication.lastPage
degois.publication.titleJournal of the American Heart Association
degois.publication.volume8
dspace.entity.typePublication
rcaap.rightsopenAccess

Ficheiros

Principais
A mostrar 1 - 1 de 1
Miniatura
Nome:
JAHA.118.011536.pdf
Tamanho:
531.59 KB
Formato:
Adobe Portable Document Format
Ver/Abrir

Coleções

NMS: CEDOC - Artigos em revista internacional com arbitragem científica