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Measurement of internal diameters of capillaries and glass syringes using gravimetric and optical methods for microflow applications

2023-02-01Artigo científico Acesso aberto
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dc.contributor.authorBatista, Elsa
dc.contributor.authorÁlvares, Miguel
dc.contributor.authorMartins, Rui F.
dc.contributor.authorOgheard, Florestan
dc.contributor.authorGeršl, Jan
dc.contributor.authorGodinho, Isabel
dc.contributor.institutionDEMI - Departamento de Engenharia Mecânica e Industrial
dc.contributor.institutionUNIDEMI - Unidade de Investigação e Desenvolvimento em Engenharia Mecânica e Industrial
dc.contributor.pblWalter de Gruyter GmbH
dc.date.accessioned2022-11-28T22:15:32Z
dc.date.available2022-11-28T22:15:32Z
dc.date.issued2023-02-01
dc.descriptionThis work performed under 18HLT08 MeDDII project has received funding from the EMPIR programme co-financed by the Participating States and from the European Union’s Horizon 2020 research and innovation programme. The Authors would like to acknowledge Abir Wissam Boudaoud for her help in CETIAT inner diameter measurements and Václav Duchoň and Petr Grolich from CMI for their work on the glass syringe diameter calibration. © 2022 the author(s), published by De Gruyter, Berlin/Boston.
dc.description.abstractOBJECTIVES: Microflow measurement devices are used in several science and health applications, mainly drug delivery. In the last decade, several new methods based on optical technology were developed, namely the front tracking and interferometric method, in which the knowledge of the inner diameter of the syringe or the capillary used is critical. Only a few National Metrology Institutes (NMIs) can perform inner diameter measurements below 1 mm, which requires expensive technology. Therefore, IPQ, in cooperation with CETIAT, CMI and UNIDEMI, under the EMPIR project 18HLT08 MeDDII - Metrology for Drug Delivery, developed new measurement methods for small inner diameter tubes based on the gravimetric principle and optical methods in order to simplify the apparatus used for this type of measurements without increasing uncertainty. METHODS: The gravimetric experimental setup consists of measuring the liquid volume on a specific length of the glass tube. The optical method used is based on the front track principle that uses a high-resolution camera and ImageJ software, to determine the diameter at both ends of each capillary. RESULTS: To validate the developed methods, a comparison was performed between CETIAT, CMI and IPQ and the results obtained were all consistent. CONCLUSIONS: This work allowed the determination of inner diameter of syringes or capillaries using two different methods with relative expanded uncertainties from 0.1 to 0.5% ( k=2), that can be applied for flow measurements using optical technology.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent10
dc.format.extent5901206
dc.identifier.doi10.1515/bmt-2022-0033
dc.identifier.issn0013-5585
dc.identifier.otherPURE: 47748696
dc.identifier.otherPURE UUID: 8a5ed91f-86a3-4d76-8884-9c48c891bc45
dc.identifier.otherPubMed: 36347268
dc.identifier.otherWOS: 000880007400001
dc.identifier.otherScopus: 85142360372
dc.identifier.urihttp://hdl.handle.net/10362/145853
dc.language.isoeng
dc.peerreviewedyes
dc.titleMeasurement of internal diameters of capillaries and glass syringes using gravimetric and optical methods for microflow applicationsen
dc.typejournal article
degois.publication.titleBiomedizinische Technik
dspace.entity.typePublication
rcaap.rightsopenAccess

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