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Essential Trace Elements Status in Portuguese Pregnant Women and Their Association with Maternal and Neonatal Outcomes

2023-10-21Artigo científico Acesso aberto
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dc.contributor.authorBracchi, Isabella
dc.contributor.authorGuimarães, Juliana
dc.contributor.authorRodrigues, Catarina
dc.contributor.authorAzevedo, Rui
dc.contributor.authorCoelho, Cláudia Matta
dc.contributor.authorPinheiro, Cátia
dc.contributor.authorMorais, Juliana
dc.contributor.authorBarreiros-Mota, Inês
dc.contributor.authorFernandes, Virgínia Cruz
dc.contributor.authorDelerue-Matos, Cristina
dc.contributor.authorPinto, Edgar
dc.contributor.authorMoreira-Rosário, André
dc.contributor.authorde Azevedo, Luís Filipe Ribeiro
dc.contributor.authorDias, Cláudia Camila
dc.contributor.authorLima, Jorge
dc.contributor.authorSapinho, Inês
dc.contributor.authorRamalho, Carla
dc.contributor.authorCalhau, Conceição
dc.contributor.authorCalhau, Conceição
dc.contributor.authorLeite, João Costa
dc.contributor.authorAlmeida, Agostinho
dc.contributor.authorPestana, Diogo
dc.contributor.authorKeating, Elisa
dc.contributor.institutionComprehensive Health Research Centre (CHRC) - pólo NMS
dc.contributor.institutionNOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
dc.contributor.institutionCentro de Investigação em Tecnologias e Serviços de Saúde (CINTESIS)
dc.contributor.pblMDPI - Multidisciplinary Digital Publishing Institute
dc.date.accessioned2023-11-28T22:38:18Z
dc.date.available2023-11-28T22:38:18Z
dc.date.issued2023-10-21
dc.description.abstractCobalt (Co), copper (Cu), manganese (Mn), molybdenum (Mo), and zinc (Zn) are essential trace elements (ETEs) and important cofactors for intermediary metabolism or redox balance. These ETEs are crucial during pregnancy, their role on specific pregnancy outcomes is largely unknown. This prospective study (#NCT04010708) aimed to assess urinary levels of these ETEs in pregnancy and to evaluate their association with pregnancy outcomes. First trimester pregnant women of Porto and Lisbon provided a random spot urine sample, and sociodemographic and lifestyle data. Clinical data were obtained from clinical records. Urinary ETEs were quantified by inductively coupled plasma mass spectrometry (ICP-MS). A total of 635 mother:child pairs were included. Having urinary Zn levels above the 50th percentile (P50) was an independent risk factor for pre-eclampsia (PE) (aOR [95% CI]: 5.350 [1.044-27.423], p = 0.044). Urinary Zn levels above the P50 decreased the risk of small for gestational age (SGA) birth head circumference (aOR [95% CI]: 0.315 [0.113-0.883], p = 0.028), but it increased the risk SGA length (aOR [95% CI]: 2.531 [1.057-6.062], p = 0.037). This study may provide valuable information for public health policies related to prenatal nutrition, while informing future efforts to de-fine urinary reference intervals for ETEs in pregnant women.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent1176192
dc.identifier.doi10.3390/biology12101351
dc.identifier.issn2079-7737
dc.identifier.otherPURE: 76900506
dc.identifier.otherPURE UUID: 9d96d8cc-ae28-48d6-bccb-01b36feb2c0f
dc.identifier.otherPubMed: 37887061
dc.identifier.otherPubMedCentral: PMC10604833
dc.identifier.otherWOS: 001094246500001
dc.identifier.otherScopus: 85189443301
dc.identifier.urihttp://hdl.handle.net/10362/160681
dc.language.isoeng
dc.peerreviewedyes
dc.subjectessential trace elements
dc.subjectneonatal anthropometry
dc.subjectneonatal outcomes
dc.subjectpre-eclampsia
dc.subjectpregnancy
dc.subjectpregnancy complications
dc.subjectSDG 3 - Good Health and Well-being
dc.titleEssential Trace Elements Status in Portuguese Pregnant Women and Their Association with Maternal and Neonatal Outcomesen
dc.title.subtitleA Prospective Study from the IoMum Cohorten
dc.typejournal article
degois.publication.issue10
degois.publication.titleBiology
degois.publication.volume12
dspace.entity.typePublication
person.familyNameCalhau
person.givenNameConceição
person.identifier.ciencia-id2110-0420-1717
person.identifier.orcid0000-0001-9567-3379
person.identifier.scopus-author-id6701578877
rcaap.rightsopenAccess
relation.isAuthorOfPublication32b016c8-810a-40be-b9ee-ddfb07668a78
relation.isAuthorOfPublication.latestForDiscovery32b016c8-810a-40be-b9ee-ddfb07668a78

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