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Molecular classification of endometrial cancer

2024-08Artigo científico Acesso aberto
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dc.contributor.authorCasanova, João
dc.contributor.authorda Costa, Ana G.
dc.contributor.authorLopes, Ana Pestana
dc.contributor.authorCatarino, Ana
dc.contributor.authorNave, Mónica
dc.contributor.authorSousa, Ana Carla
dc.contributor.authorLima, Jorge
dc.contributor.institutionNOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
dc.contributor.institutionComprehensive Health Research Centre (CHRC) - pólo NMS
dc.contributor.pblSpringer Verlag
dc.date.accessioned2024-09-27T22:22:36Z
dc.date.available2024-09-27T22:22:36Z
dc.date.issued2024-08
dc.descriptionPublisher Copyright: Copyright © 2024 Casanova, da Costa, Lopes, Catarino, Nave, Sousa and Lima.
dc.description.abstractBackground: Since the seminal publication of the TCGA consortium in 2013, the molecular classification of endometrial cancer has been widely accepted as a new and powerful tool to better understand the natural history of this malignancy. Adoption of routine molecular classification around the world has been limited. We sought to demonstrate our initial experience in incorporating the four molecular subtypes for endometrioid carcinomas. Methods: This was a retrospective analysis at a single center in Portugal. Molecular classification was determined using immunohistochemical staining for MMR and p53 and Sanger Sequencing to determine POLE mutation status as per published PROMISE method. Descriptive statistics were reported. Results: 20 patients with endometrioid histology were included. Median age of the cohort was 64 years (range 45–76). Median Body Mass Index (kg/m2) was 29.81 (range 21.3–43.1). In terms of tumor grading, 16 (80%) of the endometrial carcinomas of the cohort were low-grade (either grade 1 or grade 2). 16 (80%) of the cases were FIGO stage I. Regarding the molecular classification the tumors were classified as: MMRd [n = 6 (30%)]; p53 abn [n = 2 (10%)]; NSMP (n = 10 (50%)), POLE ultramut [n = 2 (10%)]. Conclusion: Despite the small sample size, we were able to show that molecular classification is feasible. To our knowledge this is the first cohort of endometroid endometrial carcinomas fully characterized according to the TCGA classification in Portugal, from one single center.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent2077961
dc.identifier.doi10.3389/pore.2024.1611835
dc.identifier.issn1219-4956
dc.identifier.otherPURE: 99182773
dc.identifier.otherPURE UUID: 677dcdc0-241e-4b14-b684-babcfb95f8d9
dc.identifier.otherScopus: 85202691650
dc.identifier.otherPubMed: 39220299
dc.identifier.urihttp://hdl.handle.net/10362/172567
dc.identifier.urlhttps://www.scopus.com/pages/publications/85202691650
dc.language.isoeng
dc.peerreviewedyes
dc.subjectDNA sequencing
dc.subjectendometrial cancer
dc.subjectmolecular profiling
dc.subjectmolecular subtypes
dc.subjectPOLE mutation
dc.subjectPathology and Forensic Medicine
dc.subjectOncology
dc.subjectCancer Research
dc.subjectSDG 3 - Good Health and Well-being
dc.titleMolecular classification of endometrial canceren
dc.title.subtitlepreliminary experience from a single Portuguese academic centeren
dc.typejournal article
degois.publication.titlePathology and Oncology Research
degois.publication.volume30
dspace.entity.typePublication
rcaap.rightsopenAccess

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