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Regulation of Staphylococcus aureus Virulence and Application of Nanotherapeutics to Eradicate S. aureus Infection

2023-01-17Recensão Acesso aberto
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dc.contributor.authorArunachalam, Kannappan
dc.contributor.authorPandurangan, Poonguzhali
dc.contributor.authorShi, Chunlei
dc.contributor.authorLagoa, Ricardo
dc.contributor.institutionUCIBIO - Applied Molecular Biosciences Unit
dc.contributor.pblMDPI AG
dc.date.accessioned2023-09-22T22:16:45Z
dc.date.available2023-09-22T22:16:45Z
dc.date.issued2023-01-17
dc.descriptionFunding Information: The authors gratefully acknowledge financial support from the Science and Technology Commission of Shanghai Municipality of China (Grant No. 21N31900200) and Natural Science Foundation of China (Grant Nos. 32001798, 31972169). Publisher Copyright: © 2023 by the authors.
dc.description.abstractStaphylococcus aureus is a versatile pathogen known to cause hospital- and community-acquired, foodborne, and zoonotic infections. The clinical infections by S. aureus cause an increase in morbidity and mortality rates and treatment costs, aggravated by the emergence of drug-resistant strains. As a multi-faceted pathogen, it is imperative to consolidate the knowledge on its pathogenesis, including the mechanisms of virulence regulation, development of antimicrobial resistance, and biofilm formation, to make it amenable to different treatment strategies. Nanomaterials provide a suitable platform to address this challenge, with the potential to control intracellular parasitism and multidrug resistance where conventional therapies show limited efficacy. In a nutshell, the first part of this review focuses on the impact of S. aureus on human health and the role of virulence factors and biofilms during pathogenesis. The second part discusses the large diversity of nanoparticles and their applications in controlling S. aureus infections, including combination with antibiotics and phytochemicals and the incorporation of antimicrobial coatings for biomaterials. Finally, the limitations and prospects using nanomaterials are highlighted, aiming to foster the development of novel nanotechnology-driven therapies against multidrug-resistant S. aureus.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent48
dc.format.extent3640607
dc.identifier.doi10.3390/pharmaceutics15020310
dc.identifier.issn1999-4923
dc.identifier.otherPURE: 72173260
dc.identifier.otherPURE UUID: 9fcb7b9a-f62a-44be-a507-24813247c06b
dc.identifier.otherScopus: 85148729956
dc.identifier.otherWOS: 000940029300001
dc.identifier.otherPubMed: 36839634
dc.identifier.otherPubMedCentral: PMC9960757
dc.identifier.urihttp://hdl.handle.net/10362/158158
dc.identifier.urlhttps://www.scopus.com/pages/publications/85148729956
dc.language.isoeng
dc.peerreviewedyes
dc.relationinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F04378%2F2020/PT
dc.relationApplied Molecular Biosciences Unit
dc.relationApplied Molecular Biosciences Unit
dc.subjectantibacterial activity
dc.subjectbiofilm inhibition
dc.subjectdrug delivery
dc.subjectnanotechnology
dc.subjectStaphylococcus aureus
dc.subjectPharmaceutical Science
dc.subjectSDG 3 - Good Health and Well-being
dc.titleRegulation of Staphylococcus aureus Virulence and Application of Nanotherapeutics to Eradicate S. aureus Infectionen
dc.typereview
degois.publication.issue2
degois.publication.titlePharmaceutics
degois.publication.volume15
dspace.entity.typePublication
oaire.awardNumberUIDP/04378/2020
oaire.awardNumberUIDB/04378/2020
oaire.awardTitleApplied Molecular Biosciences Unit
oaire.awardTitleApplied Molecular Biosciences Unit
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F04378%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04378%2F2020/PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccess
relation.isProjectOfPublication38373452-5c9c-4724-8def-f03314ecce0e
relation.isProjectOfPublicatione07cf232-4705-4b5b-b2c4-af8f25311076
relation.isProjectOfPublication.latestForDiscoverye07cf232-4705-4b5b-b2c4-af8f25311076

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