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Assessing the role of ultra-processed foods in colorectal cancer incidence

2026-12Artigo científico Acesso aberto
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dc.contributor.authorBerden, Jeroen
dc.contributor.authorLangselius, Oliver
dc.contributor.authorGonzález-Gil, Esther M.
dc.contributor.authorLopez, Jessica Blanco
dc.contributor.authorNicolas, Geneviève
dc.contributor.authorSrour, Bernard
dc.contributor.authorMillett, Christopher
dc.contributor.authorVamos, Eszter P.
dc.contributor.authorRumgay, Harriet
dc.contributor.authorChang, Kiara
dc.contributor.authorTouvier, Mathilde
dc.contributor.authorHeath, Alicia K.
dc.contributor.authorKyrø, Cecilie
dc.contributor.authorMarques, Chloé
dc.contributor.authorJannasch, Franziska
dc.contributor.authorSchulze, Matthias B.
dc.contributor.authorFranco, Matteo
dc.contributor.authorZabala, Ana M.Jimenez
dc.contributor.authorTjønneland, Anne
dc.contributor.authorvan Gils, Carla H.
dc.contributor.authorLe Cornet, Charlotte
dc.contributor.authorCadeau, Claire
dc.contributor.authorGuevara, Marcela
dc.contributor.authorSanchez, Maria José
dc.contributor.authorHajji-Louati, Mariem
dc.contributor.authorCrous-Bou, Marta
dc.contributor.authorTumino, Rosario
dc.contributor.authorPala, Valeria
dc.contributor.authorKatzke, Verena
dc.contributor.authorSkeie, Guri
dc.contributor.authorVineis, Paolo
dc.contributor.authorFerrari, Pietro
dc.contributor.authorViallon, Vivian
dc.contributor.authorHuybrechts, Inge
dc.contributor.institutionCentro de Investigação em Saúde Pública (CISP/PHRC)
dc.contributor.institutionComprehensive Health Research Centre (CHRC) - Pólo ENSP
dc.contributor.institutionEscola Nacional de Saúde Pública (ENSP)
dc.contributor.pblBioMed Central (BMC)
dc.date.accessioned2026-08-04T08:44:01Z
dc.date.available2026-08-04T08:44:01Z
dc.date.issued2026-12
dc.descriptionPublisher Copyright: © The Author(s) 2026.
dc.description.abstractBackground: Studies have reported associations between ultra-processed food (UPF) consumption and colorectal cancer (CRC) incidence, yet the magnitude of these associations remains unclear. This study estimated the cohort-associated fraction (CAF), adapted from the population-attributable fraction metric, between UPF consumption and CRC incidence and explored the potential benefits of substituting UPFs with unprocessed or minimally processed foods. Methods: Using data from 416,081 middle-aged adults in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort, including 5,845 incident CRC cases, Cox proportional hazards models were applied to estimate associations between UPF consumption (grams/day) and CRC, colon and rectal cancer risks. Substitution analyses were also carried out to estimate associations of replacing UPFs with unprocessed or minimally processed foods, to reflect potentially more interpretable estimates. CAFs quantified the magnitude of these associations. Results: UPF consumption was positively associated with colon cancer (HR1-SD Increment: 1.04 [95%CI: 1.01; 1.08]) and CRC (HR1-SD Increment: 1.04 [95%CI: 1.01; 1.07]) but not with rectal cancer incidence. The CAF for UPF consumption was 5.58% (95%CI: 0.55; 10.50) for colon, and 5.10% (1.10; 9.02) for CRC incidence. Substituting 1-SD of UPFs with unprocessed or minimally processed foods was inversely associated with colon cancer (HR: 0.93, [95%CI: 0.89; 0.97]) and CRC incidence (HR: 0.94, [95%CI: 0.92; 0.98]), in energy- and nutrient-adjusted models. In substitution models, the CAF increased to 9.67% (4.36; 14.85) for colon cancer and 7.30% (3.05; 11.48) for CRC incidence. Conclusion: We estimated the magnitude of associations between UPF consumption and CRC incidence, highlighting the potential public health relevance of reducing UPF intake. Given the rising consumption of UPFs and burden of CRC incidence, public health interventions and continued research are needed to address this growing issue.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent1922044
dc.identifier.doi10.1186/s12889-026-27225-3
dc.identifier.issn1471-2458
dc.identifier.otherPURE: 170406478
dc.identifier.otherPURE UUID: aa346279-7bba-4f5f-bba9-8ace5ca2523f
dc.identifier.otherScopus: 105041070459
dc.identifier.otherPubMed: 42021246
dc.identifier.otherPubMedCentral: PMC13235047
dc.identifier.otherWOS: 001784532500005
dc.identifier.urihttp://hdl.handle.net/10362/205064
dc.identifier.urlhttps://www.scopus.com/pages/publications/105041070459
dc.language.isoeng
dc.peerreviewedyes
dc.subjectCancer epidemiology
dc.subjectCohort-attributable fraction (CAF)
dc.subjectColorectal cancer (CRC)
dc.subjectEPIC cohort
dc.subjectFood processing
dc.subjectUltra-processed foods (UPF)
dc.subjectPublic Health, Environmental and Occupational Health
dc.subjectSDG 3 - Good Health and Well-being
dc.titleAssessing the role of ultra-processed foods in colorectal cancer incidenceen
dc.title.subtitleinsights from the EPIC cohorten
dc.typejournal article
degois.publication.issue1
degois.publication.titleBMC Public Health
degois.publication.volume26
dspace.entity.typePublication
rcaap.rightsopenAccess

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