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Tuberculosis in children under 5 years of age in a low-burden setting

2026-01Artigo científico Acesso aberto
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dc.contributor.authorFronteira, Inês
dc.contributor.authorPacheco, Matilde
dc.contributor.authorVilichane, Ivinildo
dc.contributor.authorRicardo, Edgar
dc.contributor.authorAguiar, Pedro
dc.contributor.authorDuarte, Raquel
dc.contributor.authorFerrinho, Paulo
dc.contributor.institutionLaboratório Associado de Translacção e Inovação para a Saúde Global - LA Real (Pólo ENSP)
dc.contributor.institutionCentro de Investigação em Saúde Pública (CISP/PHRC)
dc.contributor.institutionComprehensive Health Research Centre (CHRC) - Pólo ENSP
dc.contributor.institutionEscola Nacional de Saúde Pública (ENSP)
dc.contributor.institutionGlobal Health and Tropical Medicine (GHTM)
dc.contributor.institutionInstituto de Higiene e Medicina Tropical (IHMT)
dc.contributor.pblSpringer Verlag
dc.date.accessioned2026-04-15T12:15:01Z
dc.date.available2026-04-15T12:15:01Z
dc.date.issued2026-01
dc.descriptionPublisher Copyright: © The Author(s) 2026.
dc.description.abstractPurpose: To describe the sociodemographic and epidemiological characteristics and healthcare utilization patterns—primary healthcare (PHC) use, emergency department (ED) visits, and hospital admissions—of children under 5 years of age born in Portugal between July 1, 2010, and June 30, 2021, and diagnosed with TB during the same period. Methods: This is a quantitative, observational cohort study of 58 children diagnosed with TB and reported to the National Epidemiological Surveillance System (SINAVE) before age 5. Data were obtained through linkage of five population-based databases. Descriptive statistics and bivariate analyses were conducted. Incidence rates of PHC, ED visits, and hospital admissions were calculated per 1000 person-days. Results: Most TB cases (81.0%) were diagnosed between ages 1 and 5; 55.2% were male, and 72.2% resided in metropolitan areas. Over half (58.6%) were unvaccinated with BCG. Unvaccinated children were diagnosed earlier than vaccinated peers (p < 0.01), though no significant differences were found in the clinical presentation of TB, risk factors, or healthcare utilization. Pulmonary TB was most common (51.7%), and 68.4% of children were hospitalized. PHC services were underutilized (32.7%), while ED visits were more frequent, primarily for infectious and respiratory conditions. One child died, with TB diagnosed post-mortem. Conclusions: TB in young children remains a public health concern in Portugal, especially in unvaccinated populations. Strengthening PHC access and preventive care is essential to improve early detection and outcomes.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent848007
dc.identifier.doi10.1007/s00431-025-06704-6
dc.identifier.issn0340-6199
dc.identifier.otherPURE: 160529462
dc.identifier.otherPURE UUID: 83a03f0c-8151-447b-83df-5b700130a4d5
dc.identifier.otherScopus: 105026391305
dc.identifier.otherPubMed: 41483248
dc.identifier.otherPubMedCentral: PMC12764675
dc.identifier.otherWOS: 001653212900001
dc.identifier.otherORCID: /0000-0003-1406-4585/work/211855940
dc.identifier.urihttp://hdl.handle.net/10362/202240
dc.identifier.urlhttps://www.scopus.com/pages/publications/105026391305
dc.language.isoeng
dc.peerreviewedyes
dc.subjectHealthcare utilization
dc.subjectSurveillance
dc.subjectTB
dc.subjectUnder five children
dc.subjectPediatrics, Perinatology, and Child Health
dc.subjectSDG 3 - Good Health and Well-being
dc.titleTuberculosis in children under 5 years of age in a low-burden settingen
dc.title.subtitlesociodemographic and epidemiological characteristics and healthcare utilization over a 10-year period (2010–2021)en
dc.typejournal article
degois.publication.issue1
degois.publication.titleEuropean Journal Of Pediatrics
degois.publication.volume185
dspace.entity.typePublication
rcaap.rightsopenAccess

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