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D-PRISM

2024-12Artigo científico Acesso aberto
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dc.contributor.authorReyes, Luis Felipe
dc.contributor.authorSerrano-Mayorga, Cristian C.
dc.contributor.authorZhang, Zhongheng
dc.contributor.authorTsuji, Isabela
dc.contributor.authorDe Pascale, Gennaro
dc.contributor.authorPrieto, Valeria Enciso
dc.contributor.authorMer, Mervyn
dc.contributor.authorSheehan, Elyce
dc.contributor.authorNasa, Prashant
dc.contributor.authorZangana, Goran
dc.contributor.authorAvanti, Kostoula
dc.contributor.authorTabah, Alexis
dc.contributor.authorShrestha, Gentle Sunder
dc.contributor.authorBracht, Hendrik
dc.contributor.authorFatoni, Arie Zainul
dc.contributor.authorAbidi, Khalid
dc.contributor.authorSulaiman, Helmi bin
dc.contributor.authorEshwara, Vandana Kalwaje
dc.contributor.authorDe Bus, Liesbet
dc.contributor.authorHayashi, Yoshiro
dc.contributor.authorKorkmaz, Pervin
dc.contributor.authorHssain, Ali Ait
dc.contributor.authorBuetti, Niccollò
dc.contributor.authorGoh, Qing Yuan
dc.contributor.authorKwizera, Arthur
dc.contributor.authorKoulenti, Despoina
dc.contributor.authorNielsen, Nathan D.
dc.contributor.authorPovoa, Pedro
dc.contributor.authorPovoa, Pedro
dc.contributor.authorRanzani, Otavio
dc.contributor.authorRello, Jordi
dc.contributor.authorConway Morris, Andrew
dc.contributor.authorHamed, Islam
dc.contributor.authorShaban, Nesreen
dc.contributor.authorYeh, Tony
dc.contributor.authorBuetti, Niccollò
dc.contributor.authorSjovall, Fredrik
dc.contributor.authorHanifa, Rashan
dc.contributor.authorKuzovlev, Artem
dc.contributor.authorHssain, Ali Ait
dc.contributor.authorNora, David
dc.contributor.authorLuque, Nestor
dc.contributor.authorHashmi, Madiha
dc.contributor.authorBuowari, Dabota
dc.contributor.authorSchouten, Jeroen
dc.contributor.authorShrestha, Gentle
dc.contributor.authorLagunes, Leonel
dc.contributor.authorSulaiman, Helmi bin
dc.contributor.authorViderman, Dimitry
dc.contributor.authorZand, Faird
dc.contributor.authorZainul, Arie
dc.contributor.institutionNOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
dc.contributor.pblBioMed Central (BMC)
dc.date.accessioned2024-12-18T17:28:14Z
dc.date.available2024-12-18T17:28:14Z
dc.date.issued2024-12
dc.descriptionPublisher Copyright: © The Author(s) 2024.
dc.description.abstractBackground: Pneumonia remains a significant global health concern, particularly among those requiring admission to the intensive care unit (ICU). Despite the availability of international guidelines, there remains heterogeneity in clinical management. The D-PRISM study aimed to develop a global overview of how pneumonias (i.e., community-acquired (CAP), hospital-acquired (HAP), and Ventilator-associated pneumonia (VAP)) are diagnosed and treated in the ICU and compare differences in clinical practice worldwide. Methods: The D-PRISM study was a multinational, survey-based investigation to assess the diagnosis and treatment of pneumonia in the ICU. A self-administered online questionnaire was distributed to intensive care clinicians from 72 countries between September to November 2022. The questionnaire included sections on professional profiles, current clinical practice in diagnosing and managing CAP, HAP, and VAP, and the availability of microbiology diagnostic tests. Multivariable analysis using multiple regression analysis was used to assess the relationship between reported antibiotic duration and organisational variables collected in the study. Results: A total of 1296 valid responses were collected from ICU clinicians, spread between low-and-middle income (LMIC) and high-income countries (HIC), with LMIC respondents comprising 51% of respondents. There is heterogeneity across the diagnostic processes, including clinical assessment, where 30% (389) did not consider radiological evidence essential to diagnose pneumonia, variable collection of microbiological samples, and use and practice in bronchoscopy. Microbiological diagnostics were least frequently available in low and lower-middle-income nation settings. Modal intended antibiotic treatment duration was 5–7 days for all types of pneumonia. Shorter durations of antibiotic treatment were associated with antimicrobial stewardship (AMS) programs, high national income status, and formal intensive care training. Conclusions: This study highlighted variations in clinical practice and diagnostic capabilities for pneumonia, particularly issues with access to diagnostic tools in LMICs were identified. There is a clear need for improved adherence to existing guidelines and standardized approaches to diagnosing and treating pneumonia in the ICU. Trial registration As a survey of current practice, this study was not registered. It was reviewed and endorsed by the European Society of Intensive Care Medicine. Graphical abstract: (Figure presented.)en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent2138315
dc.identifier.doi10.1186/s13054-024-05180-y
dc.identifier.issn1364-8535
dc.identifier.otherPURE: 104162232
dc.identifier.otherPURE UUID: 0e3e16b2-4726-428d-b08a-b1b108193333
dc.identifier.otherScopus: 85210005694
dc.identifier.otherWOS: 001364205100002
dc.identifier.urihttp://hdl.handle.net/10362/176466
dc.identifier.urlhttps://www.scopus.com/pages/publications/85210005694
dc.language.isoeng
dc.peerreviewedyes
dc.subjectAntimicrobials
dc.subjectBronchoscopy
dc.subjectCommunity-acquired
dc.subjectHospital-acquired
dc.subjectIntensive care unit (ICU)
dc.subjectPneumonia
dc.subjectSurveys and questionnaires
dc.subjectVentilator-associated
dc.subjectCritical Care and Intensive Care Medicine
dc.titleD-PRISMen
dc.title.subtitlea global survey-based study to assess diagnostic and treatment approaches in pneumonia managed in intensive careen
dc.typejournal article
degois.publication.issue1
degois.publication.titleCritical Care
degois.publication.volume28
dspace.entity.typePublication
person.familyNamePovoa
person.givenNamePedro
person.identifier.ciencia-id0C16-5CF9-9238
person.identifier.orcid0000-0002-7069-7304
person.identifier.scopus-author-id6602772147
rcaap.rightsopenAccess
relation.isAuthorOfPublication04ec38ba-be1e-46e5-8007-0e65a557d0f4
relation.isAuthorOfPublication.latestForDiscovery04ec38ba-be1e-46e5-8007-0e65a557d0f4

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