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Low-energy electrons transform the nimorazole molecule into a radiosensitiser

2019-12-01Artigo científico Acesso aberto
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dc.contributor.authorMeißner, Rebecca
dc.contributor.authorKočišek, Jaroslav
dc.contributor.authorFeketeová, Linda
dc.contributor.authorFedor, Juraj
dc.contributor.authorFárník, Michal
dc.contributor.authorLimão-Vieira, Paulo
dc.contributor.authorIllenberger, Eugen
dc.contributor.authorDenifl, Stephan
dc.contributor.institutionDF – Departamento de Física
dc.contributor.institutionCeFITec – Centro de Física e Investigação Tecnológica
dc.contributor.pblNature Portfolio
dc.date.accessioned2020-09-30T22:22:49Z
dc.date.available2020-09-30T22:22:49Z
dc.date.issued2019-12-01
dc.descriptionThis work was supported by FWF, Vienna (P30332). R.M. and P.L.V. acknowledge the Portuguese National Funding Agency FCT-MCTES through PD/BD/114452/2016 and research grants UID/FIS/00068/2019 (CEFITEC) and PTDC/FIS-AQM/31281/2017. This work was also supported by Radiation Biology and Biophysics Doctoral Training Programme (RaBBiT, PD/00193/2010); UID/Multi/04378/2019 (UCIBIO). J.K. acknowledges the support by the Czech Science Foundation Grant 19-01159S. L.F. is grateful to the LABEX Lyon Institute of Origins (ANR-10-LABX-0066) of the Universite de Lyon for its financial support within the program "Investissements d'Avenir" (ANR-11-IDEX-0007) of the French government operated by the National Research Agency (ANR).
dc.description.abstractWhile matter is irradiated with highly-energetic particles, it may become chemically modified. Thereby, the reactions of free low-energy electrons (LEEs) formed as secondary particles play an important role. It is unknown to what degree and by which mechanism LEEs contribute to the action of electron-affinic radiosensitisers applied in radiotherapy of hypoxic tumours. Here we show that LEEs effectively cause the reduction of the radiosensitiser nimorazole via associative electron attachment with the cross-section exceeding most of known molecules. This supports the hypothesis that nimorazole is selectively cytotoxic to tumour cells due to reduction of the molecule as prerequisite for accumulation in the cell. In contrast, dissociative electron attachment, commonly believed to be the source of chemical activity of LEEs, represents only a minor reaction channel which is further suppressed upon hydration. Our results show that LEEs may strongly contribute to the radiosensitising effect of nimorazole via associative electron attachment.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent1146401
dc.identifier.doi10.1038/s41467-019-10340-8
dc.identifier.issn2041-1723
dc.identifier.otherPURE: 18783922
dc.identifier.otherPURE UUID: 6b39df2b-c8e6-48f8-82df-8d194188d57a
dc.identifier.otherScopus: 85067185294
dc.identifier.otherPubMed: 31160602
dc.identifier.otherPubMedCentral: PMC6546713
dc.identifier.otherWOS: 000469909200006
dc.identifier.otherORCID: /0000-0003-2696-1152/work/151411970
dc.identifier.urihttp://hdl.handle.net/10362/104982
dc.identifier.urlhttps://www.scopus.com/pages/publications/85067185294
dc.language.isoeng
dc.peerreviewedyes
dc.subjectGeneral Chemistry
dc.subjectGeneral Biochemistry,Genetics and Molecular Biology
dc.subjectGeneral Physics and Astronomy
dc.titleLow-energy electrons transform the nimorazole molecule into a radiosensitiseren
dc.typejournal article
degois.publication.issue1
degois.publication.titleNature Communications
degois.publication.volume10
dspace.entity.typePublication
rcaap.rightsopenAccess

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