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Adenoma incidence decreases under the effect of polypectomy

2012-03-21Artigo científico Acesso aberto
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dc.contributor.authorRosa, Isadora
dc.contributor.authorFidalgo, Paulo
dc.contributor.authorSoares, José
dc.contributor.authorVinga, Susana
dc.contributor.authorOliveira, Carla
dc.contributor.authorSilva, João P.
dc.contributor.authorFerro, Susana M.
dc.contributor.authorChaves, Paula
dc.contributor.authorOliveira, António G.
dc.contributor.authorLeitão, Carlos N.
dc.contributor.institutionNOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
dc.contributor.pblBaishideng Publishing Group Inc
dc.date.accessioned2017-09-15T22:03:49Z
dc.date.available2017-09-15T22:03:49Z
dc.date.issued2012-03-21
dc.description.abstractAIM: To investigate whether, under the influence of polypectomy, the incidence of adenoma decreases with age. METHODS: Consecutive patients with colonic adenomas identified at index colonoscopy were retrospectively selected if they had undergone three or more complete colonoscopies, at least 24 mo apart. Patients who had any first-degree relative with colorectal cancer were excluded. Data regarding number of adenomas at each colonoscopy, their location, size and histological classification were recorded. The monthly incidence density of adenomas after the index examination was estimated for the study population, by using the person-years method. Baseline adenomas were excluded from incidence calculations but their characteristics were correlated with recurrence at follow-up, using the χ 2 test. RESULTS: One hundred and fifty-six patients were included (109 male, mean age at index colonoscopy 56.8 ± 10.3 years), with follow-up that ranged from 48 to 232 mo. No significant correlations were observed between the number, the presence of villous component, or the size of adenomas at index colonoscopy and the presence of adenomas at subsequent colonoscopies (P = 0.49, 0.12 and 0.78, respectively). The incidence of colonic adenomas was observed to decay from 1.4% person-months at the beginning of the study to values close to 0%, at 12 years after index colonoscopy. CONCLUSION: Our results suggest the sporadic formation of adenomas occurs within a discrete period and that, when these adenomas are removed, all neoplasia-prone clones may be extinguished.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent6
dc.format.extent814765
dc.identifier.doi10.3748/wjg.v18.i11.1243
dc.identifier.issn1007-9327
dc.identifier.otherPURE: 3133185
dc.identifier.otherPURE UUID: dd20fd81-bb08-414b-860d-2652dc759f9d
dc.identifier.otherScopus: 84858766237
dc.identifier.otherPubMed: 22468088
dc.identifier.otherWOS: 000302190400013
dc.identifier.urihttp://www.scopus.com/inward/record.url?scp=84858766237&partnerID=8YFLogxK
dc.identifier.urlhttps://www.scopus.com/pages/publications/84858766237
dc.language.isoeng
dc.peerreviewedyes
dc.subjectAge
dc.subjectColorectal adenoma
dc.subjectColorectal cancer
dc.subjectIncidence
dc.subjectPolypectomy
dc.subjectGastroenterology
dc.subjectSDG 3 - Good Health and Well-being
dc.titleAdenoma incidence decreases under the effect of polypectomyen
dc.typejournal article
degois.publication.firstPage1243
degois.publication.issue11
degois.publication.lastPage1248
degois.publication.titleWorld Journal of Gastroenterology
degois.publication.volume18
dspace.entity.typePublication
rcaap.rightsopenAccess

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