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Associations between syndesmophytes and facet joint ankylosis in radiographic axial spondyloarthritis patients on low-dose CT over 2 years

2022-12Artigo científico Acesso aberto
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dc.contributor.authorStal, Rosalinde
dc.contributor.authorSepriano, Alexandre
dc.contributor.authorSepriano, Alexandre
dc.contributor.authorvan Gaalen, Floris Alexander
dc.contributor.authorBaraliakos, Xenofon
dc.contributor.authorvan den Berg, Rosaline
dc.contributor.authorReijnierse, Monique
dc.contributor.authorBraun, Juergen
dc.contributor.authorLandewé, Robert B M
dc.contributor.authorvan der Heijde, Désirée
dc.contributor.institutionNOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
dc.contributor.pblBritish Society for Rheumatology | Oxford University Press
dc.date.accessioned2022-04-04T22:38:22Z
dc.date.available2022-04-04T22:38:22Z
dc.date.issued2022-12
dc.description© The Author(s) 2022. Published by Oxford University Press on behalf of the British Society for Rheumatology.
dc.description.abstractOBJECTIVES: In radiographic axial spondyloarthritis (r-axSpA), spinal damage manifests as syndesmophytes and facet joint ankylosis (FJA). We evaluated whether the presence of one lesion increased the risk of the other lesion. METHODS: Patients with r-axSpA underwent low-dose CT (ldCT) and MRI of the whole spine at baseline and two years. On ldCT, vertebrae were scored for presence and size of syndesmophytes; facet joints were assessed for ankylosis. MR images were assessed for inflammation. Two hypotheses were tested: 1) presence of FJA is associated with new syndesmophyte(s) on the same vertebral unit (VU) two years later, and 2) presence of bridging syndesmophyte(s) is associated with new FJA on the same VU two years later. Two Generalized Estimating Equations models were tested per hypothesis using increase of FJA/syndesmophytes (model A) or presence of FJA/syndesmophytes (model B) as outcome, adjusted for inflammation at baseline. Secondary analyses tested the hypotheses with outcomes on adjacent VUs and dose-response effects. RESULTS: Fifty-one patients were included (mean age 49, 84% male, 82% HLA-B27+). Baseline bridging syndesmophytes occurred more often (range: 10-60% per VU) than FJA (range: 8-36%). ORs(95%CI) for presence of bridging syndesmophytes on development of FJA were 3.55(2.03-6.21) for model A and 3.30(2.14-5.09) for model B. ORs for presence of baseline FJA on new syndesmophytes were 1.87(1.20-2.92) for model A and 1.69(0.88-3.22) for model B. Secondary analyses yielded positive ORs for both hypotheses. CONCLUSIONS: Bone formation in vertebrae and in facet joints influence each other's occurrence, with the effect of syndesmophytes being larger than that of FJA.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent465427
dc.identifier.doi10.1093/rheumatology/keac176
dc.identifier.issn1462-0324
dc.identifier.otherPURE: 42509194
dc.identifier.otherPURE UUID: 3ad7d0c7-d042-4e9f-b8ec-02f4171e557e
dc.identifier.otherPubMed: 35302592
dc.identifier.otherScopus: 85143088352
dc.identifier.urihttp://hdl.handle.net/10362/135841
dc.language.isoeng
dc.peerreviewedyes
dc.subjectradiographic axial spondyloarthritis
dc.subjectsyndesmophytes
dc.subjectfacet joints
dc.subjectankylosis
dc.subjectlow dose CT
dc.titleAssociations between syndesmophytes and facet joint ankylosis in radiographic axial spondyloarthritis patients on low-dose CT over 2 yearsen
dc.typejournal article
degois.publication.firstPage
degois.publication.issue12
degois.publication.lastPage
degois.publication.titleRheumatology
degois.publication.volume61
dspace.entity.typePublication
person.familyNameSepriano
person.givenNameAlexandre
person.identifier397398
person.identifier.ciencia-id5E1B-9976-5CE4
person.identifier.orcid0000-0003-1954-0229
person.identifier.scopus-author-id55266526300
rcaap.rightsopenAccess
relation.isAuthorOfPublicationd87df0c7-841b-4648-a99e-296348e2e286
relation.isAuthorOfPublication.latestForDiscoveryd87df0c7-841b-4648-a99e-296348e2e286

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