Logo do repositório
 
Publicação

Factors Associated With Clinical and Radiographic Severity in People With Osteoarthritis

2021-11-15Artigo científico Acesso aberto
Ver registo simples
dc.contributor.authorCosta, Daniela
dc.contributor.authorCruz, Eduardo B.
dc.contributor.authorSilva, Catarina
dc.contributor.authorCanhão, Helena
dc.contributor.authorCanhão, Helena
dc.contributor.authorBranco, Jaime
dc.contributor.authorBranco, Jaime
dc.contributor.authorNunes, Carla
dc.contributor.authorRodrigues, Ana M.
dc.contributor.institutionComprehensive Health Research Centre (CHRC) - Pólo ENSP
dc.contributor.institutionCentro de Investigação em Saúde Pública (CISP/PHRC)
dc.contributor.institutionEscola Nacional de Saúde Pública (ENSP)
dc.contributor.institutionNOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
dc.contributor.institutionCentro de Estudos de Doenças Crónicas (CEDOC)
dc.contributor.institutionComprehensive Health Research Centre (CHRC) - pólo NMS
dc.contributor.pblFrontiers Media
dc.date.accessioned2022-02-24T23:23:04Z
dc.date.available2022-02-24T23:23:04Z
dc.date.issued2021-11-15
dc.descriptionFunding Information: We thank the EpiDoc Unit and EpiReumaPt team for conceptualising, planning, and implementing the main research project. We would like to acknowledge that the present publication was supported by Fundação Ciência e Tecnologia, IP national support through CHRC (UIDP/04923/2020). Funding Information: This work was supported by an independent research grant from Pfizer. DC received national funding through FCT—Fundação para a Ciência e Tecnologia, I. P. under the Ph.D. grant SFRH/BD/148420/2019
dc.description.abstractBackground: Hip/knee osteoarthritis (HKOA) is a leading cause of disability and imposes a major socioeconomic burden. The aim of this study is to estimate the prevalence of HKOA in Portugal, characterised the clinical severity of HKOA in the population, and identified sociodemographic, lifestyle, and clinical factors associated with higher clinical and radiographic severity. Methods: Participants with a diagnosis of HKOA from the EpiReumaPt study (2011–2013) were included (n = 1,087). Hip/knee osteoarthritis diagnosis was made through a structured evaluation by rheumatologists according to American College of Rheumatology criteria. Clinical severity was classified based on Hip Disability and Osteoarthritis Outcome Scale (HOOS) and Knee Injury and Osteoarthritis Outcome Scale (KOOS) score tertiles. Radiographic severity was classified based on the Kellgren-Lawrence grades as mild, moderate, or severe. Sociodemographic lifestyle and clinical variables, including the presence of anxiety and depression symptoms, were analysed. Factors associated with higher clinical and radiographic severity were identified using ordinal logistic regression models. Results: Hip/knee osteoarthritis diagnosis was present in 14.1% of the Portuguese population [12.4% with knee osteoarthritis (OA) and 2.9% with hip OA]. Clinical severity was similar between people with hip (HOOS = 55.79 ± 20.88) and knee (KOOS = 55.33 ± 20.641) OA. People in the high HOOS/KOOS tertile tended to be older (64.39 ± 0.70 years), female (75.2%), overweight (39.0%) or obese (45.9%), and had multimorbidity (86.1%). Factors significantly associated with higher clinical severity tertile were age [55–64 years: odds ratio (OR) = 3.18; 65–74 years: OR = 3.25; ≥75 years: OR = 4.24], female sex (OR = 1.60), multimorbidity (OR = 1.75), being overweight (OR = 2.01) or obese (OR = 2.82), and having anxiety symptoms (OR = 1.83). Years of education was inversely associated with higher clinical severity. Factors significantly associated with higher radiographic severity were age (65–74 years: OR = 3.59; ≥75 years: OR = 3.05) and being in the high HOOS/KOOS tertile (OR = 4.91). Being a female and live in Lisbon or in the Centre region were inversely associated with the higher radiographic severity. Conclusion: Hip/knee osteoarthritis is present in ~1.1 million of Portuguese people. Age, educational level, and obesity are independently associated with HKOA clinical severity, whereas age, sex, geographic location, and clinical severity are independently associated with radiographic severity.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent658030
dc.identifier.doi10.3389/fmed.2021.773417
dc.identifier.issn2296-858X
dc.identifier.otherPURE: 41764716
dc.identifier.otherPURE UUID: 108d5d91-cf67-41f0-a07d-6dac6df4b805
dc.identifier.otherScopus: 85120555982
dc.identifier.otherORCID: /0000-0003-1894-4870/work/108814810
dc.identifier.otherPubMed: 34869491
dc.identifier.otherWOS: 000726115100001
dc.identifier.urihttp://hdl.handle.net/10362/133565
dc.identifier.urlhttps://www.scopus.com/pages/publications/85120555982
dc.language.isoeng
dc.peerreviewedyes
dc.subjectclinical severity
dc.subjecthip osteoarthritis
dc.subjectknee osteoarthritis
dc.subjectprevalence
dc.subjectradiographic severity
dc.subjectGeneral Medicine
dc.subjectSDG 3 - Good Health and Well-being
dc.titleFactors Associated With Clinical and Radiographic Severity in People With Osteoarthritisen
dc.title.subtitleA Cross-Sectional Population-Based Studyen
dc.typejournal article
degois.publication.titleFrontiers in medicine
degois.publication.volume8
dspace.entity.typePublication
person.familyNameCanhão
person.familyNameBranco
person.givenNameHelena
person.givenNameJaime
person.identifier379800
person.identifier.ciencia-id5A17-C6D9-DBC8
person.identifier.ciencia-idB612-E5C3-60DC
person.identifier.orcid0000-0003-1894-4870
person.identifier.orcid0000-0001-7024-4375
person.identifier.ridC-9611-2018
person.identifier.scopus-author-id6602393492
person.identifier.scopus-author-id8417815400
rcaap.rightsopenAccess
relation.isAuthorOfPublicationc87f58c0-b53d-4321-9bd7-39554e6001b5
relation.isAuthorOfPublication4caea9f3-40dd-4c95-98ec-0120509287c0
relation.isAuthorOfPublication.latestForDiscoveryc87f58c0-b53d-4321-9bd7-39554e6001b5

Ficheiros

Principais
A mostrar 1 - 1 de 1
Miniatura
Nome:
fmed_08_773417.pdf
Tamanho:
642.61 KB
Formato:
Adobe Portable Document Format
Ver/Abrir

Coleções

NMS: CHRC - Artigos em revista internacional com arbitragem científica