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Mitotic physiology and chromosome architecture of human pluripotent stem cells
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| 4.4 MB | Adobe PDF |
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"Human pluripotent stem cells (PSCs) are widely used in both basic and translational research, as well as regenerative medicine. However, 10 to 30% of PSCs present genomic and karyotypic abnormalities. PSCs exhibit unique characteristics that can help explain these abnormalities. For instance, they hyper-transcribe their genomes and experience increased replication stress during the S phase. PSCs are also known to have a more open chromatin and different histone modifications compared to somatic cells. This unique chromatin state may affect PSCs’ capability to establish proper chromosome assembly at the whole chromosome level or at specialised domains such as the centromere.(...)"
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Palavras-chave
PSCs’ mitotic cell states centromere chromosome architecture