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Potential of miR-21 to Predict Incomplete Response to Chemoradiotherapy in Rectal Adenocarcinoma

2020-10-27Artigo científico Acesso aberto
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dc.contributor.authorOurô, Susana
dc.contributor.authorMourato, Cláudia
dc.contributor.authorVelho, Sónia
dc.contributor.authorCardador, André
dc.contributor.authorFerreira, Marisa P.
dc.contributor.authorAlbergaria, Diogo
dc.contributor.authorCastro, Rui E.
dc.contributor.authorMaio, Rui
dc.contributor.authorRodrigues, Cecília M.P.
dc.contributor.institutionNOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
dc.contributor.pblFrontiers Media
dc.date.accessioned2020-12-30T05:03:42Z
dc.date.available2020-12-30T05:03:42Z
dc.date.issued2020-10-27
dc.descriptionFunding: This work has received funding from European Structural and Investment Funds through the COMPETE Programme Grant LISBOA-01-0145-FEDER-016405, from National Funds through Fundação para a Ciência e Tecnologia Programme grant SAICTPAC/0019/2015 and by a cholar from the Portuguese Society of Coloproctology as Investigation in Coloproctology Research Prize 2016–2018.
dc.description.abstractBackground: Patients with locally advanced rectal adenocarcinoma (LARC) are treated with neoadjuvant chemoradiotherapy (CRT). However, biomarkers for patient selection are lacking, and the association between miRNA expression and treatment response and oncological outcomes is unclear. Objectives: To investigate miRNAs as predictors of response to neoadjuvant CRT and its association with oncological outcomes. Methods: This retrospective study analyzed miRNA expression (miR-16, miR-21, miR-135b, miR-145, and miR-335) in pre- and post-chemoradiation rectal adenocarcinoma tissue and non-neoplastic mucosa in 91 patients treated with neoadjuvant CRT (50.4 Gy) and proctectomy. Two groups were defined: a pathological complete responders group (tumor regression grade—TRG 0) and a pathological incomplete responders group (TRG 1, 2, and 3). Results: miR-21 and miR-135b were upregulated in tumor tissue of incomplete responders comparing with non-neoplastic tissue (p = 0.008 and p < 0.0001, respectively). Multivariate analysis showed significant association between miR-21 in pre-CRT tumor tissue and response, with a 3.67 odds ratio (OR) of incomplete response in patients with higher miR-21 levels (p = 0.04). Although with no significance, patients treated with 5-fluorouracil (5-FU) presented reduced odds of incomplete response compared with those treated with capecitabine (OR = 0.19; 95% confidence interval (CI) 0.03–1.12, p = 0.05). Moreover, significant differences were seen in overall survival (OS) in relation to clinical TNM stage (p = 0.0004), cT (p = 0.0001), presence of distant disease (p = 0.002), mesorectal tumor deposits (p = 0.003), and tumor regression grade (p = 0.04). Conclusion: miR-21 may predict response to CRT in rectal cancer (RC).en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent1122562
dc.identifier.doi10.3389/fonc.2020.577653
dc.identifier.otherPURE: 26467205
dc.identifier.otherPURE UUID: afb5fefd-3c13-4c7b-bb16-8b3baec27014
dc.identifier.otherScopus: 85095958151
dc.identifier.otherWOS: 000587843400001
dc.identifier.otherPubMed: 33194696
dc.identifier.urihttp://hdl.handle.net/10362/109478
dc.identifier.urlhttps://www.scopus.com/pages/publications/85095958151
dc.language.isoeng
dc.peerreviewedyes
dc.subjectbiomarkers
dc.subjectchemoradiotherapy response
dc.subjectmiR-21
dc.subjectrectal cancer
dc.subjecttumor regression grade
dc.subjectOncology
dc.subjectCancer Research
dc.subjectSDG 3 - Good Health and Well-being
dc.titlePotential of miR-21 to Predict Incomplete Response to Chemoradiotherapy in Rectal Adenocarcinomaen
dc.typejournal article
degois.publication.titleFrontiers in Oncology
degois.publication.volume10
dspace.entity.typePublication
rcaap.rightsopenAccess

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