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Gold Nanoconjugates for miRNA Modulation in Cancer Therapy

2022-08-13Artigo científico Acesso aberto
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dc.contributor.authorSousa, Diana P.
dc.contributor.authorConde, João
dc.contributor.authorConde, João
dc.contributor.institutionCentre for Toxicogenomics and Human Health (ToxOmics)
dc.contributor.institutionNOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
dc.contributor.pblACS - American Chemical Society
dc.date.accessioned2022-08-25T22:21:23Z
dc.date.available2022-08-25T22:21:23Z
dc.date.issued2022-08-13
dc.descriptionFunding This work was supported by the FCT PhD Scholarship (2020.06638.BD, Diana P. Sousa) and by the European Research Council Starting Grant ERC-StG-2019-848325 (2019−2024, João Conde).
dc.description.abstractCancer is a major healthcare burden and cause of death worldwide, with an estimated 19.3 million new cancer cases and 10 million cancer deaths globally only in 2020. While several anticancer therapeutics are available to date, many of these still show low treatment efficacy and high off-target effects and adverse reactions. This prompts a serious need to develop novel therapies that can decrease the side effects and increase treatment efficacy. MicroRNAs (miRNAs) can have a role in tumor development and progression, making them important targets for the improvement of anticancer therapies. In this context, gold nanoparticles have been widely studied for different clinical applications due to their biocompatibility and possibility of customization, and gold nanoconjugates targeting miRNAs are being developed for cancer diagnosis and treatment. Here we summarize the research developed so far and how it can contribute to cancer treatment, discuss how it can be improved, and present the current challenges and future perspectives on their design and application.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent5309183
dc.identifier.doi10.1021/acsmaterialsau.2c00042
dc.identifier.issn2694-2461
dc.identifier.otherPURE: 46066901
dc.identifier.otherPURE UUID: b7ace35e-45d0-434d-8e76-4fe222c156c9
dc.identifier.otherScopus: 85137770593
dc.identifier.otherPubMed: 36397876
dc.identifier.otherPubMedCentral: PMC9650716
dc.identifier.urihttp://hdl.handle.net/10362/143308
dc.language.isoeng
dc.peerreviewedyes
dc.subjectCancer
dc.subjectCancer therapy
dc.subjectGene therapy
dc.subjectGold
dc.subjectNanoparticles
dc.subjectSDG 3 - Good Health and Well-being
dc.titleGold Nanoconjugates for miRNA Modulation in Cancer Therapyen
dc.title.subtitleFrom miRNA Silencing to miRNA Mimicsen
dc.typejournal article
degois.publication.firstPage626
degois.publication.issue6
degois.publication.lastPage640
degois.publication.titleACS Materials Au
degois.publication.volume2
dspace.entity.typePublication
person.familyNameConde
person.givenNameJoão
person.identifier807432
person.identifier.ciencia-idA71C-B10E-255E
person.identifier.orcid0000-0001-8422-6792
person.identifier.ridF-2231-2011
person.identifier.scopus-author-id56992468300
rcaap.rightsopenAccess
relation.isAuthorOfPublication33ca4178-1b25-4b5e-ae16-b2500abe4c58
relation.isAuthorOfPublication.latestForDiscovery33ca4178-1b25-4b5e-ae16-b2500abe4c58

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