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CD4+ and CD8+ cell populations in HIV-positive women with cervical squamous intra-epithelial lesions and squamous cell carcinoma

2021-02Artigo científico Acesso aberto
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dc.contributor.authorBrito, Maria José
dc.contributor.authorBRITO, MARIA
dc.contributor.authorSequeira, Pedro
dc.contributor.authorSilva, Iryna
dc.contributor.authorQuintas, Ana
dc.contributor.authorMartins, Catarina
dc.contributor.authorMartins, Catarina
dc.contributor.authorFélix, Ana
dc.contributor.authorFelix, Ana
dc.contributor.institutionNOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
dc.contributor.pblElsevier
dc.date.accessioned2020-12-30T05:03:37Z
dc.date.available2020-12-30T05:03:37Z
dc.date.issued2021-02
dc.descriptionCopyright © 2020. Published by Elsevier Ltd.
dc.description.abstractINTRODUCTION: This study aimed to analyse cervix lymphocytic populations in HIV + and HIV- patients and correlate different cervical lesions with HIV viral load and presence of high-risk HPV types. MATERIAL AND METHODS: A total of 132 histological specimens from 40 HIV + and 72 HIV- patients were evaluated for CD4+ and CD8+ T cell distribution, presence of high-risk HPV types, peripheral blood HIV viral load and CD4+/CD8+ ratio. RESULTS: High-grade squamous intraepithelial lesions (HSIL) and squamous cell carcinoma (SCC) from HIV + patients had lower CD4+ T cell scores compared with HIV- patients. In all lesion groups, HIV + patients presented higher epithelial and stromal CD8+ T cell scores. HIV viral load was more often detectable in patients with SCC than in those with low-grade squamous intraepithelial lesion (LSIL) (p = 0.0409). HSIL HIV + patients had lower circulating CD4+ T cell counts (p = 0.0434) and CD4+/CD8+ ratio (p = 0.0378) compared with LSIL HIV + patients. High-risk HPV types other than 16 and 18/45 were more prevalent in the HIV + group. DISCUSSION: These results support an imbalance between cervical CD4+ and CD8+ T lymphocytes of HIV + patients with SIL and SCC, with increased CD8+ infiltrate density with lesion severity, even in patients with immune system recovery under cART.en
dc.description.versionproof
dc.description.versionpublished
dc.format.extent3218917
dc.identifier.doi10.1016/j.ijid.2020.10.083
dc.identifier.issn1201-9712
dc.identifier.otherPURE: 26384625
dc.identifier.otherPURE UUID: 3250a398-35c3-4eec-a253-b5a381c93edd
dc.identifier.otherPubMed: 33157285
dc.identifier.otherORCID: /0000-0002-2653-2262/work/85969164
dc.identifier.otherORCID: /0000-0003-0353-0421/work/85970061
dc.identifier.otherScopus: 85098636842
dc.identifier.otherWOS: 000616697100004
dc.identifier.urihttp://hdl.handle.net/10362/109476
dc.language.isoeng
dc.peerreviewedyes
dc.subjectCarcinoma
dc.subjectCD4+ T cell
dc.subjectCD8+ T cell
dc.subjectCervix
dc.subjectHIV
dc.subjectViral load
dc.subjectSDG 3 - Good Health and Well-being
dc.titleCD4+ and CD8+ cell populations in HIV-positive women with cervical squamous intra-epithelial lesions and squamous cell carcinomaen
dc.typejournal article
degois.publication.firstPage370
degois.publication.lastPage377
degois.publication.titleInternational Journal of Infectious Diseases
degois.publication.volume103
dspace.entity.typePublication
person.familyNameBRITO
person.familyNameMartins
person.familyNameFelix
person.givenNameMARIA
person.givenNameCatarina
person.givenNameAna
person.identifier.ciencia-idA617-A56B-6FC6
person.identifier.orcid0000-0003-0746-2040
person.identifier.orcid0000-0003-0353-0421
person.identifier.orcid0000-0002-2653-2262
person.identifier.scopus-author-id55574221034
rcaap.rightsopenAccess
relation.isAuthorOfPublication4d68380c-7d9c-4ef4-b375-745bac001862
relation.isAuthorOfPublicationfbfcc667-a22a-43f0-8573-e6652fd04eb5
relation.isAuthorOfPublicatione267d7fd-7e65-4533-9f0a-6fceabcf4b7b
relation.isAuthorOfPublication.latestForDiscoverye267d7fd-7e65-4533-9f0a-6fceabcf4b7b

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