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Bioengineered exosomal-membrane-camouflaged abiotic nanocarriers

2023-04-27Recensão Acesso aberto
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dc.contributor.authorLopes, Daniela
dc.contributor.authorLopes, Joana
dc.contributor.authorPereira-Silva, Miguel
dc.contributor.authorPeixoto, Diana
dc.contributor.authorRabiee, Navid
dc.contributor.authorVeiga, Francisco
dc.contributor.authorMoradi, Omid
dc.contributor.authorGuo, Zhan Hu
dc.contributor.authorWang, Xiang Dong
dc.contributor.authorConde, João
dc.contributor.authorConde, João
dc.contributor.authorMakvandi, Pooyan
dc.contributor.authorPaiva-Santos, Ana Cláudia
dc.contributor.institutionNOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
dc.contributor.institutionCentre for Toxicogenomics and Human Health (ToxOmics)
dc.contributor.pblBioMed Central (BMC)
dc.date.accessioned2023-05-05T22:14:56Z
dc.date.available2023-05-05T22:14:56Z
dc.date.issued2023-04-27
dc.descriptionFunding This work was supported by grants from Fundação para a Ciência e Tecnologia (FCT) (SFRH/BD/148771/2019, 2021.05914.BD, PTDC/BTM-MAT/4738/2020), and also from the European Research Council—ERC Starting Grant (848325).
dc.description.abstractA bio-inspired strategy has recently been developed for camouflaging nanocarriers with biomembranes, such as natural cell membranes or subcellular structure-derived membranes. This strategy endows cloaked nanomaterials with improved interfacial properties, superior cell targeting, immune evasion potential, and prolonged duration of systemic circulation. Here, we summarize recent advances in the production and application of exosomal membrane-coated nanomaterials. The structure, properties, and manner in which exosomes communicate with cells are first reviewed. This is followed by a discussion of the types of exosomes and their fabrication methods. We then discuss the applications of biomimetic exosomes and membrane-cloaked nanocarriers in tissue engineering, regenerative medicine, imaging, and the treatment of neurodegenerative diseases. Finally, we appraise the current challenges associated with the clinical translation of biomimetic exosomal membrane-surface-engineered nanovehicles and evaluate the future of this technology.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent1
dc.format.extent3798284
dc.identifier.doi10.1186/s40779-023-00453-z
dc.identifier.otherPURE: 60005964
dc.identifier.otherPURE UUID: 273ffa59-00fd-4a26-b9b8-505e4d9a8ff8
dc.identifier.otherScopus: 85153905576
dc.identifier.otherPubMed: 37101293
dc.identifier.urihttp://hdl.handle.net/10362/152470
dc.identifier.urlhttps://www.scopus.com/pages/publications/85153905576
dc.language.isoeng
dc.peerreviewedyes
dc.subjectBiomimetic
dc.subjectCell membrane coating
dc.subjectExosomal-membrane-coated nanoparticle
dc.subjectExosome
dc.subjectExtracellular vesicle (EV)
dc.subjectGeneral Medicine
dc.titleBioengineered exosomal-membrane-camouflaged abiotic nanocarriersen
dc.title.subtitleneurodegenerative diseases, tissue engineering and regenerative medicineen
dc.typereview
degois.publication.firstPage
degois.publication.issue1
degois.publication.lastPage
degois.publication.titleMilitary Medical Research
degois.publication.volume10
dspace.entity.typePublication
person.familyNameConde
person.givenNameJoão
person.identifier807432
person.identifier.ciencia-idA71C-B10E-255E
person.identifier.orcid0000-0001-8422-6792
person.identifier.ridF-2231-2011
person.identifier.scopus-author-id56992468300
rcaap.rightsopenAccess
relation.isAuthorOfPublication33ca4178-1b25-4b5e-ae16-b2500abe4c58
relation.isAuthorOfPublication.latestForDiscovery33ca4178-1b25-4b5e-ae16-b2500abe4c58

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