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Antibiotic Activity Screened by the Rheology of S. aureus Cultures

2020-06Artigo científico Acesso aberto
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dc.contributor.authorPortela, Raquel
dc.contributor.authorValcovo, Filipe
dc.contributor.authorAlmeida, Pedro L.
dc.contributor.authorSobral, Rita G.
dc.contributor.authorLeal, Catarina R.
dc.contributor.institutionUCIBIO - Applied Molecular Biosciences Unit
dc.contributor.institutionDQ - Departamento de Química
dc.contributor.institutionCENIMAT-i3N - Centro de Investigação de Materiais (Lab. Associado I3N)
dc.contributor.institutionDCM - Departamento de Ciência dos Materiais
dc.contributor.pblMDPI - Multidisciplinary Digital Publishing Institute
dc.date.accessioned2021-03-22T23:28:20Z
dc.date.available2021-03-22T23:28:20Z
dc.date.issued2020-06
dc.descriptionUID/CTM/50025/2019 PTDC/BIA-MIC/31645/2017 UIDB/04378/2020 No. POCI-01-0145-FEDER-007728
dc.description.abstractMultidrug resistant bacteria are one of the most serious public health threats nowadays. How bacteria, as a population, react to the presence of antibiotics is of major importance to the outcome of the chosen treatment. In this study we addressed the impact of oxacillin, a β-lactam, the most clinically relevant class of antibiotics, in the viscosity profile of the methicillin resistant Staphylococcus aureus (MRSA) strain COL. In the first approach, the antibiotic was added, at concentrations under the minimum inhibitory concentration (sub-MIC), to the culture of S. aureus and steady-state shear flow curves were obtained for discrete time points during the bacterial growth, with and without the presence of the antibiotic, showing distinct viscosity progress over time. The different behaviors obtained led us to test the impact of the sub-inhibitory concentration and a concentration that inhibited growth. In the second approach, the viscosity growth curves were measured at a constant shear rate of 10 s-1, over time. The obtained rheological behaviors revealed distinctive characteristics associated to the presence of each concentration of the tested antibiotic. These results bring new insights to the bacteria response to a well-known bacteriolytic antibiotic.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent1669690
dc.identifier.doi10.3390/fluids5020076
dc.identifier.issn2311-5521
dc.identifier.otherPURE: 28690047
dc.identifier.otherPURE UUID: f2afa303-fa97-446e-bc31-18dcf0b4f955
dc.identifier.otherScopus: 85085998230
dc.identifier.otherWOS: 000552442400001
dc.identifier.otherORCID: /0000-0003-4533-7531/work/201987297
dc.identifier.urihttp://hdl.handle.net/10362/114281
dc.identifier.urlhttps://www.scopus.com/pages/publications/85085998230
dc.language.isoeng
dc.peerreviewedyes
dc.relationinfo:eu-repo/grantAgreement/FCT/5876/135948/PT
dc.subjectantibiotics
dc.subjectbactericidal
dc.subjectMRSA
dc.subjectoxacillin
dc.subjectrheology
dc.subjectS. aureus
dc.subjectCondensed Matter Physics
dc.subjectMechanical Engineering
dc.subjectFluid Flow and Transfer Processes
dc.subjectSDG 3 - Good Health and Well-being
dc.titleAntibiotic Activity Screened by the Rheology of S. aureus Culturesen
dc.typejournal article
degois.publication.issue2
degois.publication.titleFLUIDS
degois.publication.volume5
dspace.entity.typePublication
oaire.awardNumberPEst-OE/MAT/UI0117/2014
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/PEst-OE%2FMAT%2FUI0117%2F2014/PT
oaire.fundingStream5876
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccess
relation.isProjectOfPublication509ff1a1-4f1b-4777-b78c-5206acb4491d
relation.isProjectOfPublication.latestForDiscovery509ff1a1-4f1b-4777-b78c-5206acb4491d

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