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Gender Difference in the Effects of COVID-19 Pandemic on Mechanical Reperfusion and 30-Day Mortality for STEMI

2023-02Artigo científico Acesso aberto
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dc.contributor.authorDe Luca, Giuseppe
dc.contributor.authorManzo-Silberman, Stephane
dc.contributor.authorAlgowhary, Magdy
dc.contributor.authorUguz, Berat
dc.contributor.authorOliveira, Dinaldo C.
dc.contributor.authorGanyukov, Vladimir
dc.contributor.authorBusljetik, Oliver
dc.contributor.authorCercek, Miha
dc.contributor.authorOkkels, Lisette
dc.contributor.authorLoh, Poay Huan
dc.contributor.authorCalmac, Lucian
dc.contributor.authorFerrer, Gerard Roura i.
dc.contributor.authorQuadros, Alexandre
dc.contributor.authorMilewski, Marek
dc.contributor.authorScotto di Uccio, Fortunato
dc.contributor.authorvon Birgelen, Clemens
dc.contributor.authorVersaci, Francesco
dc.contributor.authorTen Berg, Jurrien
dc.contributor.authorCasella, Gianni
dc.contributor.authorWong Sung Lung, Aaron
dc.contributor.authorKala, Petr
dc.contributor.authorDíez Gil, José Luis
dc.contributor.authorCarrillo, Xavier
dc.contributor.authorDirksen, Maurits
dc.contributor.authorBecerra, Victor
dc.contributor.authorLee, Michael Kang yin
dc.contributor.authorJuzar, Dafsah Arifa
dc.contributor.authorde Moura Joaquim, Rodrigo
dc.contributor.authorPaladino, Roberto
dc.contributor.authorMilicic, Davor
dc.contributor.authorDavlouros, Periklis
dc.contributor.authorBakraceski, Nikola
dc.contributor.authorZilio, Filippo
dc.contributor.authorDonazzan, Luca
dc.contributor.authorKraaijeveld, Adriaan
dc.contributor.authorGalasso, Gennaro
dc.contributor.authorArpad, Lux
dc.contributor.authorMarinucci, Lucia
dc.contributor.authorGuiducci, Vincenzo
dc.contributor.authorMenichelli, Maurizio
dc.contributor.authorScoccia, Alessandra
dc.contributor.authorYamac, Aylin Hatice
dc.contributor.authorUgur Mert, Kadir
dc.contributor.authorFlores Rios, Xacobe
dc.contributor.authorKovarnik, Tomas
dc.contributor.authorKidawa, Michal
dc.contributor.authorMoreu, Josè
dc.contributor.authorFlavien, Vincent
dc.contributor.authorFabris, Enrico
dc.contributor.authorMartínez-Luengas, Iñigo Lozano
dc.contributor.authorBoccalatte, Marco
dc.contributor.authorOjeda, Francisco Bosa
dc.contributor.authorArellano-Serrano, Carlos
dc.contributor.authorCaiazzo, Gianluca
dc.contributor.authorCirrincione, Giuseppe
dc.contributor.authorKao, Hsien Li
dc.contributor.authorForés, Juan Sanchis
dc.contributor.authorVignali, Luigi
dc.contributor.authorPereira, Helder
dc.contributor.authorOrdoñez, Santiago
dc.contributor.authorArat Özkan, Alev
dc.contributor.authorScheller, Bruno
dc.contributor.authorLehtola, Heidi
dc.contributor.authorTeles, Rui
dc.contributor.authorMantis, Christos
dc.contributor.authorAntti, Ylitalo
dc.contributor.authorBrum Silveira, João António
dc.contributor.authorZoni, Cesar Rodrigo
dc.contributor.authorBessonov, Ivan
dc.contributor.authorUccello, Giuseppe
dc.contributor.authorKochiadakis, George
dc.contributor.authorAlexopulos, Dimitrios
dc.contributor.authorUribe, Carlos E.
dc.contributor.authorKanakakis, John
dc.contributor.authorFaurie, Benjamin
dc.contributor.authorGabrielli, Gabriele
dc.contributor.authorBarrios, Alejandro Gutierrez
dc.contributor.authorBachini, Juan Pablo
dc.contributor.authorRocha, Alex
dc.contributor.authorTam, Frankie C.C.
dc.contributor.authorRodriguez, Alfredo
dc.contributor.authorLukito, Antonia Anna
dc.contributor.authorSaint-Joy, Veauthyelau
dc.contributor.authorPessah, Gustavo
dc.contributor.authorTuccillo, Andrea
dc.contributor.authorIelasi, Alfonso
dc.contributor.authorCortese, Giuliana
dc.contributor.authorParodi, Guido
dc.contributor.authorBouraghda, Mohamed Abed
dc.contributor.authorMoura, Marcia
dc.contributor.authorKedhi, Elvin
dc.contributor.authorLamelas, Pablo
dc.contributor.authorSuryapranata, Harry
dc.contributor.authorNardin, Matteo
dc.contributor.authorVerdoia, Monica
dc.contributor.institutionNOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
dc.contributor.pblMDPI - Multidisciplinary Digital Publishing Institute
dc.date.accessioned2023-02-23T22:21:03Z
dc.date.available2023-02-23T22:21:03Z
dc.date.issued2023-02
dc.descriptionPublisher Copyright: © 2023 by the authors.
dc.description.abstractBackground. Several reports have demonstrated the impact of the COVID-19 pandemic on the management and outcome of patients with ST-segment elevation myocardial infarction (STEMI). The aim of the current analysis is to investigate the potential gender difference in the effects of the COVID-19 pandemic on mechanical reperfusion and 30-day mortality for STEMI patients within the ISACS-STEMI COVID-19 Registry. Methods. This retrospective multicenter registry was performed in high-volume primary percutaneous coronary intervention (PPCI) centers on four continents and included STEMI patients undergoing PPCIs in March–June 2019 and 2020. Patients were divided according to gender. The main outcomes were the incidence and timing of the PPCI, (ischemia time ≥ 12 h and door-to-balloon ≥ 30 min) and in-hospital or 30-day mortality. Results. We included 16683 STEMI patients undergoing PPCIs in 109 centers. In 2020 during the pandemic, there was a significant reduction in PPCIs compared to 2019 (IRR 0.843 (95% CI: 0.825–0.861, p < 0.0001). We did not find a significant gender difference in the effects of the COVID-19 pandemic on the numbers of STEMI patients, which were similarly reduced from 2019 to 2020 in both groups, or in the mortality rates. Compared to prepandemia, 30-day mortality was significantly higher during the pandemic period among female (12.1% vs. 8.7%; adjusted HR [95% CI] = 1.66 [1.31–2.11], p < 0.001) but not male patients (5.8% vs. 6.7%; adjusted HR [95% CI] = 1.14 [0.96–1.34], p = 0.12). Conclusions. The COVID-19 pandemic had a significant impact on the treatment of patients with STEMI, with a 16% reduction in PPCI procedures similarly observed in both genders. Furthermore, we observed significantly increased in-hospital and 30-day mortality rates during the pandemic only among females. Trial registration number: NCT 04412655.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent917993
dc.identifier.doi10.3390/jcm12030896
dc.identifier.issn2077-0383
dc.identifier.otherPURE: 53991680
dc.identifier.otherPURE UUID: f5c820bc-df00-4ecb-b5e1-9628bd7e761c
dc.identifier.otherScopus: 85147814169
dc.identifier.otherPubMed: 36769546
dc.identifier.urihttp://hdl.handle.net/10362/149623
dc.identifier.urlhttps://www.scopus.com/pages/publications/85147814169
dc.language.isoeng
dc.peerreviewedyes
dc.subjectCOVID-19
dc.subjectgender
dc.subjectpercutaneous coronary intervention
dc.subjectST-segment elevation myocardial infarction
dc.subjectGeneral Medicine
dc.titleGender Difference in the Effects of COVID-19 Pandemic on Mechanical Reperfusion and 30-Day Mortality for STEMIen
dc.title.subtitleResults of the ISACS-STEMI COVID-19 Registryen
dc.typejournal article
degois.publication.issue3
degois.publication.titleJournal of Clinical Medicine
degois.publication.volume12
dspace.entity.typePublication
rcaap.rightsopenAccess

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