Logo do repositório
 
Publicação

Identification of clinical phenotypes of peripheral involvement in patients with spondyloarthritis, including psoriatic arthritis

2021-11-08Artigo científico Acesso aberto
Ver registo simples
dc.contributor.authorLópez-Medina, Clementina
dc.contributor.authorChevret, Sylvie
dc.contributor.authorMolto, Anna
dc.contributor.authorSieper, Joachim
dc.contributor.authorDuruöz, Tuncay
dc.contributor.authorKiltz, Uta
dc.contributor.authorElzorkany, Bassel
dc.contributor.authorHajjaj-Hassouni, Najia
dc.contributor.authorBurgos-Vargas, Ruben
dc.contributor.authorMaldonado-Cocco, José
dc.contributor.authorZiade, Nelly
dc.contributor.authorGavali, Meghna
dc.contributor.authorNavarro-Compan, Victoria
dc.contributor.authorLuo, Shue Fen
dc.contributor.authorBiglia, Alessandro
dc.contributor.authorTae-Jong, Kim
dc.contributor.authorKishimoto, Mitsumasa
dc.contributor.authorPimentel-Santos, Fernando M.
dc.contributor.authorM. Pimentel-Santos, F.
dc.contributor.authorGu, Jieruo
dc.contributor.authorMuntean, Laura
dc.contributor.authorVan Gaalen, Floris A.
dc.contributor.authorGeher, Pál
dc.contributor.authorMagrey, Marina
dc.contributor.authorIbáñez-Vodnizza, Sebastián E.
dc.contributor.authorBautista-Molano, Wilson
dc.contributor.authorMaksymowych, Walter
dc.contributor.authorMacHado, Pedro M.
dc.contributor.authorLandewé, Robert
dc.contributor.authorVan Der Heijde, Desirée
dc.contributor.authorDougados, Maxime
dc.contributor.institutionNOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
dc.contributor.pblBMJ Publishing Group
dc.date.accessioned2021-12-10T23:38:22Z
dc.date.available2021-12-10T23:38:22Z
dc.date.issued2021-11-08
dc.description.abstractObjective To identify clusters of peripheral involvement according to the specific location of peripheral manifestations (ie, arthritis, enthesitis and dactylitis) in patients with spondyloarthritis (SpA) including psoriatic arthritis (PsA), and to evaluate whether these clusters correspond with the clinical diagnosis of a rheumatologist. Methods Cross-sectional study with 24 participating countries. Consecutive patients diagnosed by their rheumatologist as PsA, axial SpA or peripheral SpA were enrolled. Four different cluster analyses were conducted: one using information on the specific location from all the peripheral manifestations, and a cluster analysis for each peripheral manifestation, separately. Multiple correspondence analyses and k-means clustering methods were used. Distribution of peripheral manifestations and clinical characteristics were compared across the different clusters. Results The different cluster analyses performed in the 4465 patients clearly distinguished a predominantly axial phenotype (cluster 1) and a predominantly peripheral phenotype (cluster 2). In the predominantly axial phenotype, hip involvement and lower limb large joint arthritis, heel enthesitis and lack of dactylitis were more prevalent. In the predominantly peripheral phenotype, different subgroups were distinguished based on the type and location of peripheral involvement: a predominantly involvement of upper versus lower limbs joints, a predominantly axial enthesitis versus peripheral enthesitis, and predominantly finger versus toe involvement in dactylitis. A poor agreement between the clusters and the rheumatologist € s diagnosis as well as with the classification criteria was found. Conclusion These results suggest the presence of two main phenotypes (predominantly axial and predominantly peripheral) based on the presence and location of the peripheral manifestations.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent1430801
dc.identifier.doi10.1136/rmdopen-2021-001728
dc.identifier.issn2044-6055
dc.identifier.otherPURE: 35022362
dc.identifier.otherPURE UUID: 9202da7b-2296-40c3-8c72-f0009e8032fe
dc.identifier.otherScopus: 85119191865
dc.identifier.urihttp://hdl.handle.net/10362/129001
dc.identifier.urlhttps://www.scopus.com/pages/publications/85119191865
dc.language.isoeng
dc.peerreviewedyes
dc.subjectankylosing
dc.subjectarthritis
dc.subjectpsoriatic
dc.subjectspondylitis
dc.subjectImmunology and Allergy
dc.subjectRheumatology
dc.subjectImmunology
dc.titleIdentification of clinical phenotypes of peripheral involvement in patients with spondyloarthritis, including psoriatic arthritisen
dc.title.subtitleA cluster analysis in the worldwide ASAS-PerSpA studyen
dc.typejournal article
degois.publication.issue3
degois.publication.titleRMD Open
degois.publication.volume7
dspace.entity.typePublication
person.familyNamePimentel-Santos
person.givenNameFernando
person.identifier394707
person.identifier.ciencia-idCE12-F61E-3227
person.identifier.orcid0000-0002-2816-7705
person.identifier.scopus-author-id35249227600
rcaap.rightsopenAccess
relation.isAuthorOfPublicationdc1c295c-5cad-49f3-9b79-26b1fd03de49
relation.isAuthorOfPublication.latestForDiscoverydc1c295c-5cad-49f3-9b79-26b1fd03de49

Ficheiros

Principais
A mostrar 1 - 1 de 1
Miniatura
Nome:
e001728.full.pdf
Tamanho:
1.36 MB
Formato:
Adobe Portable Document Format
Ver/Abrir

Coleções

NMS - Artigos em revista internacional com arbitragem científica