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Comportamento biológico de isolados de Trypanosoma cruzi obtidos no Estado do Amazonas, Amazônia Ocidental Brasileira, em camundongos

2012-03Artigo científico Acesso aberto
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dc.contributor.authorMonteiro, Wuelton Marcelo
dc.contributor.authorMagalhães, Laylah Kelre Costa
dc.contributor.authorOliveira, Josué Costa
dc.contributor.authorGuerra, Jorge Augusto de Oliveira
dc.contributor.authorSilveira, Henrique
dc.contributor.authorFerreira, Luiz Carlos de Lima
dc.contributor.authorToledo, Max Jean de Ornelas
dc.contributor.authorBarbosa, Maria das Graças Vale
dc.contributor.institutionInstituto de Higiene e Medicina Tropical (IHMT)
dc.contributor.pblSociedade Brasileira de Medicina Tropical
dc.date.accessioned2021-05-05T23:25:31Z
dc.date.available2021-05-05T23:25:31Z
dc.date.issued2012-03
dc.description.abstractIntroduction: The biological diversity of circulating Trypanosoma cruzi stocks in the Amazon region most likely plays an important role in the peculiar clinic-epidemiological features of Chagas disease in this area. Methods: Seven stocks of T. cruzi were recently isolated in the State of Amazonas, Brazil, from humans, wild mammals, and triatomines. They belonged to the TcI and Z3 genotypes and were biologically characterized in Swiss mice. Parasitological and histopathological parameters were determined. Results: Four stocks did not promote patent parasitemia in mice. Three stocks produced low parasitemia, long pre-patent periods, and a patent period of 1 day or oscillating parasitemia. Maximum parasitemia ranged from 1,400 to 2,800 trypomastigotes/0.1mL blood. Mice inoculated with the T. cruzi stocks studied showed low positivity during fresh blood examinations, ranging from 0% to 28.6%. In hemoculture, positivity ranged from 0% to 100%. Heart tissue parasitism was observed in mice inoculated with stocks AM49 and AM61. Stock AM49 triggered a moderate inflammatory process in heart tissue. A mild inflammatory process was observed in heart tissue for stocks AM28, AM38, AM61, and AM69. An inflammatory process was frequently observed in skeletal muscle. Examinations of brain tissue revealed inflammatory foci and gliosis in mice inoculated with stock AM49. Conclusions: Biological and histopathological characterization allowed us to demonstrate the low infectivity and virulence of T. cruzi stocks isolated from the State of Amazonas.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent6
dc.format.extent1562275
dc.identifier.doi10.1590/S0037-86822012000200014
dc.identifier.issn0037-8682
dc.identifier.otherPURE: 26755222
dc.identifier.otherPURE UUID: 3406c4bf-87db-47a4-8433-8c714e6b4ca8
dc.identifier.otherScopus: 84860381305
dc.identifier.otherPubMed: 22534994
dc.identifier.otherWOS: 000303209600014
dc.identifier.otherORCID: /0000-0002-7939-772X/work/84883122
dc.identifier.urihttp://hdl.handle.net/10362/117142
dc.identifier.urlhttps://www.scopus.com/pages/publications/84860381305
dc.language.isopor
dc.peerreviewedyes
dc.subjectAmazon
dc.subjectChagas disease
dc.subjectPathogenicity
dc.subjectSwiss mice
dc.subjectTrypanosoma cruzi
dc.subjectVirulence
dc.subjectParasitology
dc.subjectInfectious Diseases
dc.subjectImmunology
dc.subjectSDG 3 - Good Health and Well-being
dc.titleComportamento biológico de isolados de Trypanosoma cruzi obtidos no Estado do Amazonas, Amazônia Ocidental Brasileira, em camundongospt
dc.title.alternativeBiological behavior of Trypanosoma cruzi stocks obtained from the State of Amazonas, Western Brazilian Amazon, in miceen
dc.typejournal article
degois.publication.firstPage209
degois.publication.issue2
degois.publication.lastPage214
degois.publication.titleRevista Da Sociedade Brasileira De Medicina Tropical
degois.publication.volume45
dspace.entity.typePublication
rcaap.rightsopenAccess

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