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Iron Metabolism and the Inflammatory Response

2017-06-01Artigo científico Acesso aberto
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dc.contributor.authorMartins, Ana Catarina
dc.contributor.authorAlmeida, J.I.
dc.contributor.authorLima, I.S.
dc.contributor.authorKapitão, A.S.
dc.contributor.authorGozzelino, R.
dc.contributor.institutionNOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
dc.contributor.institutionCentro de Estudos de Doenças Crónicas (CEDOC)
dc.contributor.pblBlackwell Publishing Ltd
dc.date.accessioned2023-04-14T22:14:46Z
dc.date.available2023-04-14T22:14:46Z
dc.date.issued2017-06-01
dc.descriptionFunding: This work was partially supported by iNOVA4Health-UID Multi/04462—a program financially supported by Fundação para a Ciência e Tecnologia/Ministério da Educação e Ciência, through national funds and co-funded by FEDER under the PT2020 Partnership—and Fundação para a Ciência e Tecnologia, which financial support grants fellowships to A.M. (SFRH/ BD/104599/2014), I.M. (SFRH/BD/114552/2016), A.K., J.A., and R.G. (IF/01495/2015).
dc.description.abstractIron (Fe) is essential to almost all organisms, as required by cells to satisfy metabolic needs and accomplish specialized functions. Its ability to exchange electrons between different substrates, however, renders it potentially toxic. Fine tune-mechanisms are necessary to maintain Fe homeostasis and, as such, to prevent its participation into the Fenton reaction and generation of oxidative stress. These are particularly important in the context of inflammation/infection, where restricting Fe availability to invading pathogens is one, if not, the main host defense strategy against microbial growth. The ability of Fe to modulate several aspects of the immune response is associated with a number of “costs” and “benefits”, some of which have been described in this review. © 2017 IUBMB Life, 69(6):442–450, 2017. © 2017 International Union of Biochemistry and Molecular Biologyen
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent9
dc.format.extent544983
dc.identifier.doi10.1002/iub.1635
dc.identifier.issn1521-6543
dc.identifier.otherPURE: 3228029
dc.identifier.otherPURE UUID: 9ac6daa5-efd6-4038-adf9-f6932e0b4aab
dc.identifier.otherRIS: urn:61F714788E9D0231224053FECD985FA0
dc.identifier.otherScopus: 85018728678
dc.identifier.otherPubMed: 28474474
dc.identifier.otherWOS: 000403902700008
dc.identifier.urihttp://hdl.handle.net/10362/151819
dc.identifier.urlhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85018728678&doi=10.1002%2fiub.1635&partnerID=40&md5=dbdf4db75088fde6bac326ab05d137a5
dc.language.isoeng
dc.peerreviewedyes
dc.subjectimmunity
dc.subjectinfection
dc.subjectinflammation
dc.subjectiron
dc.subjectiron metabolism
dc.subjectArticle
dc.subjectFenton reaction
dc.subjecthost resistance
dc.subjecthuman
dc.subjectimmune response
dc.subjectimmunoregulation
dc.subjectiron absorption
dc.subjectmicrobial growth
dc.subjectoxidative stress
dc.titleIron Metabolism and the Inflammatory Responseen
dc.typejournal article
degois.publication.firstPage442
degois.publication.issue6
degois.publication.lastPage450
degois.publication.titleIubmb Life
degois.publication.volume69
dspace.entity.typePublication
rcaap.rightsopenAccess

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