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Severity of RSV infection in Southern European elderly patients during two consecutive winter seasons (2017–2018)

2021-08Artigo científico Acesso aberto
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dc.contributor.authorBoattini, Matteo
dc.contributor.authorAlmeida, André
dc.contributor.authorChristaki, Eirini
dc.contributor.authorMarques, Torcato Moreira
dc.contributor.authorTosatto, Valentina
dc.contributor.authorBianco, Gabriele
dc.contributor.authorIannaccone, Marco
dc.contributor.authorTsiolakkis, Georgios
dc.contributor.authorKaragiannis, Christos
dc.contributor.authorMaikanti, Panagiota
dc.contributor.authorCruz, Lourenço
dc.contributor.authorAntão, Diogo
dc.contributor.authorMoreira, Maria Inês
dc.contributor.authorCavallo, Rossana
dc.contributor.authorCosta, Cristina
dc.contributor.institutionNOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
dc.contributor.pblJohn Wiley & Sons, Ltd.
dc.date.accessioned2022-03-22T23:24:58Z
dc.date.available2022-03-22T23:24:58Z
dc.date.issued2021-08
dc.description.abstractIn Europe, the respiratory syncytial virus (RSV) surveillance system is very heterogeneous and there is growing evidence of the importance of RSV infections resulting in hospitalization of elderly patients. The aim of this study was to assess the severity of RSV infection in the elderly living in the aged Southern European countries. We conducted a retrospective study of elderly patients (≥65-year old) admitted for laboratory-confirmed RSV infection in three tertiary hospitals in Portugal, Italy, and Cyprus over two consecutive winter seasons (2017–2018). Uni-multivariable analyses were carried out to evaluate the effect of clinical variables on radiologically confirmed pneumonia, use of noninvasive ventilation (NIV), and in-hospital death (IHD). A total of 166 elderly patients were included. Pneumonia was evident in 29.5%. NIV was implemented in 16.3%, length of stay was 11.8 ± 12.2 days, and IHD occurred in 12.1%. Multivariable analyses revealed that the risk of pneumonia was higher in patients with chronic kidney disease (CKD) (odds ratio [OR]: 2.57; 95% confidence interval [CI]: 1.12–5.91); the use of NIV was higher in patients with obstructive sleep apnea or obesity hypoventilation syndrome (OSA or OHS) (OR: 5.38; 95% CI: 1.67–17.35) and CKD (OR: 2.52; 95% CI: 1.01–6.23); the risk of IHD was higher in males (OR: 3.30; 95% CI: 1.07–10.10) and in patients with solid neoplasm (OR: 9.06; 95% CI: 2.44–33.54) and OSA or OHS (OR: 8.39; 95% CI: 2.14–32.89). Knowledge of factors associated with RSV infection severity may aid clinicians to set priorities and reduce disease burden. Development of effective antiviral treatment and vaccine against RSV is highly desirable.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent677936
dc.identifier.doi10.1002/jmv.26938
dc.identifier.issn0146-6615
dc.identifier.otherPURE: 29088489
dc.identifier.otherPURE UUID: b3d5f8de-9aed-43a6-9012-89d8ce379f86
dc.identifier.otherScopus: 85102890377
dc.identifier.otherPubMed: 33704814
dc.identifier.otherWOS: 000631352900001
dc.identifier.urihttp://hdl.handle.net/10362/135037
dc.identifier.urlhttps://www.scopus.com/pages/publications/85102890377
dc.language.isoeng
dc.peerreviewedyes
dc.subjectelderly
dc.subjectgeriatrics
dc.subjectobesity hypoventilation syndrome
dc.subjectobstructive sleep apnea
dc.subjectpneumonia
dc.subjectrespiratory syncytial virus
dc.subjectVirology
dc.subjectInfectious Diseases
dc.subjectSDG 3 - Good Health and Well-being
dc.titleSeverity of RSV infection in Southern European elderly patients during two consecutive winter seasons (2017–2018)en
dc.typejournal article
degois.publication.firstPage5152
degois.publication.issue8
degois.publication.lastPage5157
degois.publication.titleJournal Of Medical Virology
degois.publication.volume93
dspace.entity.typePublication
rcaap.rightsopenAccess

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