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Appraisal of Triglyceride-Related Markers as Early Predictors of Metabolic Outcomes in the PREVIEW Lifestyle Intervention

2021-11-01Artigo científico Acesso aberto
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dc.contributor.authorNavas-Carretero, Santiago
dc.contributor.authorSan-Cristobal, Rodrigo
dc.contributor.authorSiig Vestentoft, Pia
dc.contributor.authorBrand-Miller, Jennie C.
dc.contributor.authorJalo, Elli
dc.contributor.authorWesterterp-Plantenga, Margriet
dc.contributor.authorSimpson, Elizabeth J.
dc.contributor.authorHandjieva-Darlenska, Teodora
dc.contributor.authorStratton, Gareth
dc.contributor.authorHuttunen-Lenz, Maija
dc.contributor.authorLam, Tony
dc.contributor.authorMuirhead, Roslyn
dc.contributor.authorPoppitt, Sally
dc.contributor.authorPietiläinen, Kirsi H.
dc.contributor.authorAdam, Tanja
dc.contributor.authorTaylor, Moira A.
dc.contributor.authorHandjiev, Svetoslav
dc.contributor.authorMcNarry, Melitta A.
dc.contributor.authorHansen, Sylvia
dc.contributor.authorBrodie, Shannon
dc.contributor.authorSilvestre, Marta P.
dc.contributor.authorMacdonald, Ian A.
dc.contributor.authorBoyadjieva, Nadka
dc.contributor.authorMackintosh, Kelly A.
dc.contributor.authorSchlicht, Wolfgang
dc.contributor.authorLiu, Amy
dc.contributor.authorLarsen, Thomas M.
dc.contributor.authorFogelholm, Mikael
dc.contributor.authorRaben, Anne
dc.contributor.authorMartinez, J. Alfredo
dc.contributor.institutionNOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
dc.contributor.pblFrontiers Media
dc.date.accessioned2021-12-10T23:38:26Z
dc.date.available2021-12-10T23:38:26Z
dc.date.issued2021-11-01
dc.descriptionFunding Information: The PREVIEW consortium would like to thank all the study participants at all intervention centers for their time and commitment and all scientists, advisors, and students for their dedication and contributions to the study. Specifically, we would like to thank Louise Dye (chairman of the Scientific Advisory Board, SAB), University of Leeds, UK, Richard Atkinson (Ethical Officer of the SAB), Virginia Commonwealth University, USA, and medical expert and consultant Stephen Colagiuri (University of Sydney, Australia). Meyers Madhus A/S is acknowledged for providing training and producing 2 cooking books. Furthermore, we gratefully thank the research staff from each center. From UCPH: Laura Pastor-Sanz, Grith M?ller, Lone Vestergaard Nielsen, Kasper Nowak, Arne Astrup, Finn Sand?-Pedersen, Morten Bo Johansen, Ulla Skovb?ch Pedersen, Maria Roed Andersen, Marianne Juhl Hansen, Jane J?rgensen, Sofie Skov Frost, and Lene Stevner. From HEL: Heikki Tikkanen, Saara Kettunen, Tiia Kunnas, Sanna Ritola, Laura Korpip??, Heini Hyv?rinen, Karoliina Himanen, Tiina Pellinen, Elina Malkam?ki, Heidi Jokinen, Pauliina Kokkonen, Liisi Korhonen, Jaana Valkeap??, Heli Pikkarainen, Martta Nieminen, Tuulia Ingman, Pihla M?kinen, and Sonja Toijonen. From UNOTT: Clare Randall, Nicky Gilbert, Shelley Archer, Sally Maitland, Melanie Marshall, Cheryl Percival, Jakki Pritchard, Laura Helm, and Peter Mansell. From UNAV: Blanca Martinez de Morentin, Maria Hernandez Ruiz de Eguilaz, Salome Perez Diez, Veronica Ciaurriz, Angels Batlle, and Maria Jose Cobo. From MU: Georgi Bogdanov, Pavlina Gateva, Rossica Metodieva, and Galia Dobrevska. From SU: Nils Swindell, Jeff Stephens, Gareth Dunseath, Steve Luzio, and Masoumeh Minou. From THL: Jouko Soundvall, Laura Ram?n, Merja Tukiainen, Ira Greinert, Laura Karjalainen, and Jukka Lauronen. From UNSYD: Fiona Atkinson, Michele Whittle, Jessica Burke, Kylie Simpson, Kimberley Way, Sally McClintock, Radhika Seimon, Shelly Keating, Kirsten Bell, Tania Markovic, Cathy Corry, Evalyn Eldering, and Ian Caterson. From UOA: Lindsay Plank, Nicholas Gant, Jon Woodhead, Anne-Thea McGill, Katya Volkova, Madhavi Bollineni, Clarence Vivar, Kelly Storey, Niamh Brennan, and Audrey Tay. Publisher Copyright: Copyright © 2021 Navas-Carretero, San-Cristobal, Siig Vestentoft, Brand-Miller, Jalo, Westerterp-Plantenga, Simpson, Handjieva-Darlenska, Stratton, Huttunen-Lenz, Lam, Muirhead, Poppitt, Pietiläinen, Adam, Taylor, Handjiev, McNarry, Hansen, Brodie, Silvestre, Macdonald, Boyadjieva, Mackintosh, Schlicht, Liu, Larsen, Fogelholm, Raben and Martinez.
dc.description.abstractBackground: Individuals with pre-diabetes are commonly overweight and benefit from dietary and physical activity strategies aimed at decreasing body weight and hyperglycemia. Early insulin resistance can be estimated via the triglyceride glucose index {TyG = Ln [TG (mg/dl) × fasting plasma glucose (FPG) (mg/dl)/2]} and the hypertriglyceridemic-high waist phenotype (TyG-waist), based on TyG x waist circumference (WC) measurements. Both indices may be useful for implementing personalized metabolic management. In this secondary analysis of a randomized controlled trial (RCT), we aimed to determine whether the differences in baseline TyG values and TyG-waist phenotype predicted individual responses to type-2 diabetes (T2D) prevention programs. Methods: The present post-hoc analyses were conducted within the Prevention of Diabetes through Lifestyle intervention and population studies in Europe and around the world (PREVIEW) study completers (n = 899), a multi-center RCT conducted in eight countries (NCT01777893). The study aimed to reduce the incidence of T2D in a population with pre-diabetes during a 3-year randomized intervention with two sequential phases. The first phase was a 2-month weight loss intervention to achieve ≥8% weight loss. The second phase was a 34-month weight loss maintenance intervention with two diets providing different amounts of protein and different glycemic indices, and two physical activity programs with different exercise intensities in a 2 x 2 factorial design. On investigation days, we assessed anthropometrics, glucose/lipid metabolism markers, and diet and exercise questionnaires under standardized procedures. Results: Diabetes-related markers improved during all four lifestyle interventions. Higher baseline TyG index (p < 0.001) was associated with greater reductions in body weight, fasting glucose, and triglyceride (TG), while a high TyG-waist phenotype predicted better TG responses, particularly in those randomized to physical activity (PA) of moderate intensity. Conclusions: Two novel indices of insulin resistance (TyG and TyG-waist) may allow for a more personalized approach to avoiding progression to T2D. Clinical Trial Registration: https://clinicaltrials.gov/ct2/show/NCT01777893 reference, identifier: NCT01777893.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent3616893
dc.identifier.doi10.3389/fnut.2021.733697
dc.identifier.issn2296-861X
dc.identifier.otherPURE: 35038807
dc.identifier.otherPURE UUID: eb209c39-5383-41d2-9311-38a0153930ca
dc.identifier.otherScopus: 85119271744
dc.identifier.otherORCID: /0000-0001-9327-2897/work/104582198
dc.identifier.urihttp://hdl.handle.net/10362/129004
dc.identifier.urlhttps://www.scopus.com/pages/publications/85119271744
dc.language.isoeng
dc.peerreviewedyes
dc.subjectcarbohydrate metabolism
dc.subjectdiabetes
dc.subjecthypertriglyceridemic-waist phenotype
dc.subjectlipid markers
dc.subjectobesity
dc.subjectpre-diabetes
dc.subjectprecision nutrition
dc.subjecttriglycerides (PubChem CID: 5460048)
dc.subjectFood Science
dc.subjectEndocrinology, Diabetes and Metabolism
dc.subjectNutrition and Dietetics
dc.subjectSDG 3 - Good Health and Well-being
dc.titleAppraisal of Triglyceride-Related Markers as Early Predictors of Metabolic Outcomes in the PREVIEW Lifestyle Interventionen
dc.title.subtitleA Controlled Post-hoc Trialen
dc.typejournal article
degois.publication.titleFrontiers in Nutrition
degois.publication.volume8
dspace.entity.typePublication
rcaap.rightsopenAccess

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