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How to use biomarkers of infection or sepsis at the bedside

2023-02Artigo científico Acesso aberto
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dc.contributor.authorPóvoa, Pedro
dc.contributor.authorPovoa, Pedro
dc.contributor.authorCoelho, Luís
dc.contributor.authorDal-Pizzol, Felipe
dc.contributor.authorFerrer, Ricard
dc.contributor.authorHuttner, Angela
dc.contributor.authorConway Morris, Andrew
dc.contributor.authorNobre, Vandack
dc.contributor.authorRamirez, Paula
dc.contributor.authorRouze, Anahita
dc.contributor.authorSalluh, Jorge
dc.contributor.authorSinger, Mervyn
dc.contributor.authorSweeney, Daniel A.
dc.contributor.authorTorres, Antoni
dc.contributor.authorWaterer, Grant
dc.contributor.authorKalil, Andre C.
dc.contributor.institutionNOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
dc.contributor.pblSpringer
dc.date.accessioned2023-01-13T22:20:28Z
dc.date.available2023-01-13T22:20:28Z
dc.date.issued2023-02
dc.descriptionFunding This work received an unrestricted grant from GSK Portugal and was supported by Sociedade Portuguesa de Ginecologia (SPG).
dc.description.abstractSepsis is defined as a life-threatening organ dysfunction caused by a dysregulated host response to infection. In this context, biomarkers could be considered as indicators of either infection or dysregulated host response or response to treatment and/or aid clinicians to prognosticate patient risk. More than 250 biomarkers have been identified and evaluated over the last few decades, but no biomarker accurately differentiates between sepsis and sepsis-like syndrome. Published data support the use of biomarkers for pathogen identification, clinical diagnosis, and optimization of antibiotic treatment. In this narrative review, we highlight how clinicians could improve the use of pathogen-specific and of the most used host-response biomarkers, procalcitonin and C-reactive protein, to improve the clinical care of patients with sepsis. Biomarker kinetics are more useful than single values in predicting sepsis, when making the diagnosis and assessing the response to antibiotic therapy. Finally, integrated biomarker-guided algorithms may hold promise to improve both the diagnosis and prognosis of sepsis. Herein, we provide current data on the clinical utility of pathogen-specific and host-response biomarkers, offer guidance on how to optimize their use, and propose the needs for future research.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent1337002
dc.identifier.doi10.1007/s00134-022-06956-y
dc.identifier.issn0342-4642
dc.identifier.otherPURE: 50125976
dc.identifier.otherPURE UUID: 16ec3289-e16a-4812-b4dd-5c53d1e8a16f
dc.identifier.otherScopus: 85145504840
dc.identifier.otherPubMed: 36592205
dc.identifier.urihttp://hdl.handle.net/10362/147554
dc.identifier.urlhttps://www.scopus.com/pages/publications/85145504840
dc.language.isoeng
dc.peerreviewedyes
dc.subjectAntibiotic stewardship
dc.subjectBiomarkers
dc.subjectDiagnosis
dc.subjectIntensive care unit
dc.subjectSepsis
dc.subjectCritical Care and Intensive Care Medicine
dc.titleHow to use biomarkers of infection or sepsis at the bedsideen
dc.title.subtitleguide to cliniciansen
dc.typejournal article
degois.publication.firstPage142
degois.publication.issue2
degois.publication.lastPage153
degois.publication.titleIntensive Care Medicine
degois.publication.volume49
dspace.entity.typePublication
person.familyNamePovoa
person.givenNamePedro
person.identifier.ciencia-id0C16-5CF9-9238
person.identifier.orcid0000-0002-7069-7304
person.identifier.scopus-author-id6602772147
rcaap.rightsopenAccess
relation.isAuthorOfPublication04ec38ba-be1e-46e5-8007-0e65a557d0f4
relation.isAuthorOfPublication.latestForDiscovery04ec38ba-be1e-46e5-8007-0e65a557d0f4

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