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Differences in the genotype frequencies of genes related to blood pressure regulation-a comparative study between South-West Europe and Peri-equatorial Africa

2021-12-14Artigo científico Acesso aberto
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dc.contributor.authorAguiar, Laura
dc.contributor.authorSemente, Ildegário
dc.contributor.authorFerreira, Joana
dc.contributor.authorCarvalho, Andreia
dc.contributor.authorSilva, Alda P.
dc.contributor.authorCaroça, Cristina
dc.contributor.authorCaroça, Cristina
dc.contributor.authorCaria, Helena
dc.contributor.authorDamasceno, Albertino
dc.contributor.authorLaires, Maria J.
dc.contributor.authorSardinha, Luís
dc.contributor.authorMonteiro, Cristina
dc.contributor.authorMascarenhas, Mário R.
dc.contributor.authorFaustino, Paula
dc.contributor.authorInácio, Ângela
dc.contributor.authorBicho, Manuel
dc.contributor.institutionNOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
dc.contributor.pblMakerere University, Medical School
dc.date.accessioned2022-03-08T23:22:59Z
dc.date.available2022-03-08T23:22:59Z
dc.date.issued2021-12-14
dc.descriptionFunding Information: The authors are grateful to all study participants and would like to thank the Instituto de Investiga??o Cient?fica Bento da Rocha Cabral for financial support. Publisher Copyright: © 2021 Aguiar L et al.
dc.description.abstractBackground: Since the emergence of the genus Homo, hominids have occupied a wide variety of environments, facing different selective pressures. Objectives: The aim this study is to compare genotype frequencies between South-West Europe and Peri-equatorial Africa in genes potentially modulators of blood pressure. Methods: The analyzed sample consisted of 325 individuals from Portugal and 226 individuals from Africa (48 from Mozambique and 178 from São Tomé and Príncipe). The following genetic variants were analyzed: intron 4 VNTR in eNOS, rs1050829 in G6PD,-3.7kb α-thalassemic deletion in HBA, rs1800457 in CYB5R3, Hp 1/2 genotype/phenotype in Hp and intron 16 I/D in ACE. Results: Frequencies of genotypes with the 4a allele in eNOS (p<0.001), the G allele in G6PD (p<0.001), the α-3.7 kb in HBA (p <0.001), the C allele in the CYB5R3 (p<0.001) were higher in Peri-equatorial Africa. The Hp 1.1 genotype of Hp has a higher frequency in Peri-equatorial Africa (p=0.002). ACE shows no significant differences. Conclusion: Results show differences in five genetic variants. Conditions of extreme heat and humidity, characteristic of Peri-equatorial Africa, have been associated with increased sodium loss. This study suggests that selected compensatory mechanisms printed in the genome, are nowadays risk factors for hypertension in Peri-equatorial Africa.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent8
dc.format.extent327617
dc.identifier.doi10.4314/ahs.v21i4.21
dc.identifier.issn1680-6905
dc.identifier.otherPURE: 41977587
dc.identifier.otherPURE UUID: 532c103a-88ab-43f5-b0ec-c5a45a5d4fe2
dc.identifier.otherScopus: 85124383261
dc.identifier.otherPubMed: 35283964
dc.identifier.otherWOS: 000754471200021
dc.identifier.urihttp://hdl.handle.net/10362/134129
dc.identifier.urlhttps://www.scopus.com/pages/publications/85124383261
dc.language.isoeng
dc.peerreviewedyes
dc.subjectAfrica
dc.subjectBlood pressure
dc.subjectGenetics
dc.subjectGeneral Medicine
dc.titleDifferences in the genotype frequencies of genes related to blood pressure regulation-a comparative study between South-West Europe and Peri-equatorial Africaen
dc.typejournal article
degois.publication.firstPage1669
degois.publication.issue4
degois.publication.lastPage1676
degois.publication.titleAfrican Health Sciences
degois.publication.volume21
dspace.entity.typePublication
person.familyNameCaroça
person.givenNameCristina
person.identifier2004040
person.identifier.ciencia-id5C1F-1855-095A
person.identifier.orcid0000-0001-8096-8895
person.identifier.ridV-2835-2017
person.identifier.scopus-author-id57190608255
rcaap.rightsopenAccess
relation.isAuthorOfPublication0876cbd3-fba3-49c2-9077-205237892e5b
relation.isAuthorOfPublication.latestForDiscovery0876cbd3-fba3-49c2-9077-205237892e5b

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