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Determinants of HIV-1 late presentation in patients followed in europe

2021-07Artigo científico Acesso aberto
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dc.contributor.authorMiranda, Mafalda N.S.
dc.contributor.authorPingarilho, Marta
dc.contributor.authorPimentel, Victor
dc.contributor.authorMartins, Maria Do Rosário O.
dc.contributor.authorVandamme, Anne Mieke
dc.contributor.authorBobkova, Marina
dc.contributor.authorBöhm, Michael
dc.contributor.authorSeguin-Devaux, Carole
dc.contributor.authorParedes, Roger
dc.contributor.authorRubio, Rafael
dc.contributor.authorZazzi, Maurizio
dc.contributor.authorIncardona, Francesca
dc.contributor.authorAbecasis, Ana
dc.contributor.institutionGlobal Health and Tropical Medicine (GHTM)
dc.contributor.institutionInstituto de Higiene e Medicina Tropical (IHMT)
dc.contributor.institutionTB, HIV and opportunistic diseases and pathogens (THOP)
dc.contributor.institutionPopulation health, policies and services (PPS)
dc.contributor.pblMDPI - Multidisciplinary Digital Publishing Institute
dc.date.accessioned2021-12-07T23:42:28Z
dc.date.available2021-12-07T23:42:28Z
dc.date.issued2021-07
dc.descriptionFunding Information: This study was financed by FCT through the following projects: GHTM-UID/04413/2020, INTEGRIV (PTDC/SAU-INF/31990/2017) and the scholarship PD/BD/135714/2018 and Gilead Ge?nese HIVLatePresenters. Funding Information: Funding: This study was financed by FCT through the following projects: GHTM-UID/04413/2020, INTEGRIV (PTDC/SAU-INF/31990/2017) and the scholarship PD/BD/135714/2018 and Gilead Geénese HIVLatePresenters. Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
dc.description.abstractTo control the Human Immunodeficiency Virus (HIV) pandemic, the World Health Organization (WHO) set the 90-90-90 target to be reached by 2020. One major threat to those goals is late presentation, which is defined as an individual presenting a TCD4+ count lower than 350 cells/mm3 or an AIDS-defining event. The present study aims to identify determinants of late presentation in Europe based on the EuResist database with HIV-1 infected patients followed-up between 1981 and 2019. Our study includes clinical and socio-demographic information from 89,851 HIV-1 infected patients. Statistical analysis was performed using RStudio and SPSS and a Bayesian network was constructed with the WEKA software to analyze the association between all variables. Among 89851 HIV-1 infected patients included in the analysis, the median age was 33 (IQR: 27.0–41.0) years and 74.4% were males. Of those, 28,889 patients (50.4%) were late presenters. Older patients (>56), heterosexuals, patients originated from Africa and patients presenting with log VL >4.1 had a higher probability of being late presenters (p < 0.001). Bayesian networks indicated VL, mode of transmis-sion, age and recentness of infection as variables that were directly associated with LP. This study highlights the major determinants associated with late presentation in Europe. This study helps to direct prevention measures for this population.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent13
dc.format.extent1643631
dc.identifier.doi10.3390/pathogens10070835
dc.identifier.issn2076-0817
dc.identifier.otherPURE: 33047814
dc.identifier.otherPURE UUID: 638e616c-9ddf-40dc-8abd-6f78fb43ecc1
dc.identifier.otherScopus: 85110405857
dc.identifier.otherORCID: /0000-0002-7941-0285/work/104340108
dc.identifier.urihttp://hdl.handle.net/10362/128853
dc.identifier.urlhttps://www.scopus.com/pages/publications/85110405857
dc.language.isoeng
dc.peerreviewedyes
dc.subjectEurope
dc.subjectHIV-1 infection
dc.subjectLate presentation
dc.subjectImmunology and Allergy
dc.subjectMolecular Biology
dc.subjectGeneral Immunology and Microbiology
dc.subjectMicrobiology (medical)
dc.subjectInfectious Diseases
dc.subjectSDG 3 - Good Health and Well-being
dc.subjectSDG 10 - Reduced Inequalities
dc.titleDeterminants of HIV-1 late presentation in patients followed in europeen
dc.typejournal article
degois.publication.firstPage1
degois.publication.issue7
degois.publication.lastPage13
degois.publication.titlePathogens
degois.publication.volume10
dspace.entity.typePublication
rcaap.rightsopenAccess

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