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Aryl Hydrocarbon Receptor

2022-04-07Recensão Acesso aberto
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dc.contributor.authorRejano-Gordillo, Claudia
dc.contributor.authorOrdiales-Talavero, Ana
dc.contributor.authorNacarino-Palma, Ana
dc.contributor.authorMerino, Jaime M.
dc.contributor.authorGonzález-Rico, Francisco J.
dc.contributor.authorFernández-Salguero, Pedro M.
dc.contributor.institutionNOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
dc.contributor.institutionCentro de Estudos de Doenças Crónicas (CEDOC)
dc.contributor.pblFrontiers Media
dc.date.accessioned2022-07-06T22:35:04Z
dc.date.available2022-07-06T22:35:04Z
dc.date.issued2022-04-07
dc.description.abstractTranscription factor aryl hydrocarbon receptor (AHR) has emerged as one of the main regulators involved both in different homeostatic cell functions and tumor progression. Being a member of the family of basic-helix-loop-helix (bHLH) transcriptional regulators, this intracellular receptor has become a key member in differentiation, pluripotency, chromatin dynamics and cell reprogramming processes, with plenty of new targets identified in the last decade. Besides this role in tissue homeostasis, one enthralling feature of AHR is its capacity of acting as an oncogene or tumor suppressor depending on the specific organ, tissue and cell type. Together with its well-known modulation of cell adhesion and migration in a cell-type specific manner in epithelial-mesenchymal transition (EMT), this duality has also contributed to the arise of its clinical interest, highlighting a new potential as therapeutic tool, diagnosis and prognosis marker. Therefore, a deregulation of AHR-controlled pathways may have a causal role in contributing to physiological and homeostatic failures, tumor progression and dissemination. With that firmly in mind, this review will address the remarkable capability of AHR to exert a different function influenced by the phenotype of the target cell and its potential consequences.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent1333654
dc.identifier.doi10.3389/fcell.2022.884004
dc.identifier.issn2296-634X
dc.identifier.otherPURE: 45174212
dc.identifier.otherPURE UUID: e047e17f-80aa-43c9-8022-a6f03c6dd487
dc.identifier.otherScopus: 85128604421
dc.identifier.urihttp://hdl.handle.net/10362/141512
dc.identifier.urlhttps://www.scopus.com/pages/publications/85128604421
dc.language.isoeng
dc.peerreviewedyes
dc.subjectaryl hydrocarbon receptor
dc.subjectchromatin
dc.subjectdifferentiation
dc.subjectpluripotency
dc.subjectreprogramming
dc.subjectDevelopmental Biology
dc.subjectCell Biology
dc.titleAryl Hydrocarbon Receptoren
dc.title.subtitleFrom Homeostasis to Tumor Progressionen
dc.typereview
degois.publication.titleFrontiers in Cell and Developmental Biology
degois.publication.volume10
dspace.entity.typePublication
rcaap.rightsopenAccess

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NMS: CEDOC - Artigos em revista internacional com arbitragem científica