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A new long-term composite drug delivery system based on thermo-responsive hydrogel and nanoclay

2021-01Artigo científico Acesso aberto
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dc.contributor.authorTipa, Cezar
dc.contributor.authorCidade, Maria T.
dc.contributor.authorVieira, Tânia
dc.contributor.authorSilva, Jorge Carvalho
dc.contributor.authorSoares, Paula I. P.
dc.contributor.authorBorges, João Paulo
dc.contributor.institutionDCM - Departamento de Ciência dos Materiais
dc.contributor.institutionCENIMAT-i3N - Centro de Investigação de Materiais (Lab. Associado I3N)
dc.contributor.institutionDF – Departamento de Física
dc.contributor.pblMDPI AG
dc.date.accessioned2021-09-03T00:11:52Z
dc.date.available2021-09-03T00:11:52Z
dc.date.issued2021-01
dc.description
dc.description.abstractSeveral problems and limitations faced in the treatment of many diseases can be overcome by using controlled drug delivery systems (DDS), where the active compound is transported to the target site, minimizing undesirable side effects. In situ-forming hydrogels that can be injected as viscous liquids and jellify under physiological conditions and biocompatible clay nanoparticles have been used in DDS development. In this work, polymer–clay composites based on Pluronics (F127 and F68) and nanoclays were developed, aiming at a biocompatible and injectable system for long-term controlled delivery of methylene blue (MB) as a model drug. MB release from the systems produced was carried out at 37◦C in a pH 7.4 medium. The Pluronic formulation selected (F127/F68 18/2 wt.%) displayed a sol/gel transition at approx. 30◦C, needing a 2.5 N force to be injected at 25◦C. The addition of 2 wt.% of Na116 clay decreased the sol/gel transition to 28◦C and significantly enhanced its viscoelastic modulus. The most suitable DDS for long-term application was the Na116-MB hybrid from which, after 15 days, only 3% of the encapsulated MB was released. The system developed in this work proved to be injectable, with a long-term drug delivery profile up to 45 days.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent22
dc.format.extent5757887
dc.identifier.doi10.3390/nano11010025
dc.identifier.issn2079-4991
dc.identifier.otherPURE: 27600205
dc.identifier.otherPURE UUID: 6b486e2a-3423-4456-acda-6d707cfaa389
dc.identifier.otherScopus: 85098688116
dc.identifier.otherPubMed: 33374282
dc.identifier.otherPubMedCentral: PMC7824189
dc.identifier.otherWOS: 000610634900001
dc.identifier.otherORCID: /0000-0001-9959-4272/work/99386087
dc.identifier.otherORCID: /0000-0002-3996-6545/work/99386095
dc.identifier.otherORCID: /0000-0001-8447-1886/work/99386164
dc.identifier.otherORCID: /0000-0001-8261-6754/work/99386324
dc.identifier.urihttp://hdl.handle.net/10362/123684
dc.identifier.urlhttps://www.scopus.com/pages/publications/85098688116
dc.language.isoeng
dc.peerreviewedyes
dc.relationinfo:eu-repo/grantAgreement/FCT/9471 - RIDTI/151816/PT
dc.relationinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/154767/PT
dc.subjectBiomaterials
dc.subjectInjectable hydrogels
dc.subjectLong-term drug delivery
dc.subjectNanoclay
dc.subjectGeneral Chemical Engineering
dc.subjectGeneral Materials Science
dc.titleA new long-term composite drug delivery system based on thermo-responsive hydrogel and nanoclayen
dc.typejournal article
degois.publication.firstPage1
degois.publication.issue1
degois.publication.lastPage22
degois.publication.titleNanomaterials
degois.publication.volume11
dspace.entity.typePublication
oaire.awardNumber151816
oaire.awardNumber154767
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/9471 - RIDTI/151816/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/154767/PT
oaire.fundingStream9471 - RIDTI
oaire.fundingStream6817 - DCRRNI ID
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccess
relation.isProjectOfPublicationd247fffd-89ca-4fee-9ffa-6a9455bd58f8
relation.isProjectOfPublication0ca3ffe9-da71-48e0-9f59-8fbeb51f3613
relation.isProjectOfPublication.latestForDiscovery0ca3ffe9-da71-48e0-9f59-8fbeb51f3613

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