Logo do repositório
 
Publicação

Unveiling the potential of marine-derived diterpenes from the order Alcyonacea as promising anti-obesity agents

2024-01Artigo científico Acesso aberto
Ver registo simples
dc.contributor.authorTammam, Mohamed A.
dc.contributor.authorAly, Omnia
dc.contributor.authorPereira, Florbela
dc.contributor.authorMahdy, Aldoushy
dc.contributor.authorEl-Demerdash, Amr
dc.contributor.institutionLAQV@REQUIMTE
dc.contributor.institutionDQ - Departamento de Química
dc.contributor.pblElsevier BV
dc.date.accessioned2024-05-22T00:19:39Z
dc.date.available2024-05-22T00:19:39Z
dc.date.issued2024-01
dc.descriptionPublisher Copyright: © 2024 The Author(s)
dc.description.abstractMetabolic syndrome (MS) represents a global health challenge characterized by various metabolic disorders, including HOMA-IR (insulin resistance), obesity, dyslipidemia, and hypertension. In our pursuit of identifying natural alternatives for the development of effective and safe anti-obesity medications, we examined the potential of the methanolic extract of the Red Sea derived soft coral Sarcophyton glaucum, where serum levels of glucose, insulin, HOMA-IR, lipid profile, fetuin A and B, PTP1Β (Protein tyrosine phosphatase 1B), adropin and omentin were determined. Furthermore, the expression of the UCP1 (Uncoupling protein 1) and PPARGC1A (Peroxisome proliferator–activated receptor-g coactivator-1a) genes have been assessed, to evaluate the anti-obesity potential of S. glaucum organic extract. Our findings demonstrated a significant decrease in glucose, HOMA-IR, cholesterol, triglyceride, LDL-C, fetuin A and B, and PTP1Β levels, accompanied by a significant increase in insulin, HDL-C, adropin, omentin, UCP1, and PPARGC1A expression after treatment with the soft coral extract. These promising outcomes can be attributed to the remarkable ingredients present in the extract, which were further supported by histopathological findings. In addition, a virtual screening protocol including molecular docking (MDock) and Structure-Activity Relationships (SARs) of 27 marine diterpenes was also explored to identify potential PTP1Β inhibitors targeting simultaneously the catalytic site and allosteric site, as well as fetuin A modulators. Moreover, the six most promising predicted marine diterpenes (4, 8, 9, 10, 13 and 14) were investigated for their pharmacokinetic properties, druglike nature and medicinal chemistry friendliness using the SwissADME platform. Of these, four marine diterpenes (4, 8, 9, and 10) were predicted to exhibit the appropriate drug-like properties.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent17
dc.format.extent11971084
dc.identifier.doi10.1016/j.crbiot.2024.100175
dc.identifier.issn2590-2628
dc.identifier.otherPURE: 88889692
dc.identifier.otherPURE UUID: 623dd7ed-55cf-40ad-a81a-3c83fdf79b46
dc.identifier.otherScopus: 85183550215
dc.identifier.otherWOS: 001167571900001
dc.identifier.otherORCID: /0000-0003-4392-4644/work/160057238
dc.identifier.urihttp://hdl.handle.net/10362/167650
dc.identifier.urlhttps://www.scopus.com/pages/publications/85183550215
dc.language.isoeng
dc.peerreviewedyes
dc.relationFunding Information: info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F50006%2F2020/PT
dc.subjectAlcyonacea
dc.subjectAnti-obesity
dc.subjectDiterpenes
dc.subjectFetuin A
dc.subjectPTP1Β
dc.subjectSarcophyton glaucum
dc.subjectVirtual screening
dc.subjectBiotechnology
dc.subjectSDG 3 - Good Health and Well-being
dc.subjectSDG 14 - Life Below Water
dc.titleUnveiling the potential of marine-derived diterpenes from the order Alcyonacea as promising anti-obesity agentsen
dc.typejournal article
degois.publication.titleCurrent Research in Biotechnology
degois.publication.volume7
dspace.entity.typePublication
rcaap.rightsopenAccess

Ficheiros

Principais
A mostrar 1 - 1 de 1
Miniatura
Nome:
Unveiling_the_potential_of_marine-derived.pdf
Tamanho:
11.42 MB
Formato:
Adobe Portable Document Format
Ver/Abrir

Coleções

Home collection (FCT)