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Increased Intake of Both Caffeine and Non-Caffeine Coffee Components Is Associated with Reduced NAFLD Severity in Subjects with Type 2 Diabetes

2023-01Artigo científico Acesso aberto
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dc.contributor.authorCoelho, Margarida
dc.contributor.authorPatarrão, Rita S.
dc.contributor.authorSousa-Lima, Inês
dc.contributor.authorRibeiro, Rogério T.
dc.contributor.authorMeneses, Maria João
dc.contributor.authorAndrade, Rita
dc.contributor.authorMendes, Vera M.
dc.contributor.authorManadas, Bruno
dc.contributor.authorRaposo, João Filipe
dc.contributor.authorMacedo, M. Paula
dc.contributor.authorJones, John G.
dc.contributor.institutionNOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
dc.contributor.institutioniNOVA4Health - pólo NMS
dc.contributor.pblMDPI AG
dc.date.accessioned2023-01-18T22:17:12Z
dc.date.available2023-01-18T22:17:12Z
dc.date.issued2023-01
dc.descriptionFunding Information: This research was financed by a grant from the Institute for Scientific Information on Coffee (ISIC), by the European Regional Development Fund (ERDF), through the Centro 2020 Regional Operational Programme, the COMPETE 2020-Operational Programme for Competitiveness and Internationalization, and by Portuguese national funds via Fundação para a Ciência e Tecnologia (FCT): UIDB/04539/2020, UIDP/04539/2020, LA/P/0058/2020 and iNOVA4Health (UIDB/Multi/04462/2020). The National Mass Spectrometry Network (RNEM) provided funding under the contract POCI-01-0145-FEDER-402-022125 (ref.: ROTEIRO/0028/2013). M.C. was supported by PhD fellowship PD/BD/135178/2017, co-financed by the European Social Fund (ESF), through the POCH-Programa Operacional do Capital Humano, and national funds via FCT. Funding Information: The authors received funding from the Institute for Scientific Information on Coffee (ISIC), to perform the studies. Publisher Copyright: © 2022 by the authors.
dc.description.abstractCoffee may protect against non-alcoholic fatty liver disease (NAFLD), but the roles of the caffeine and non-caffeine components are unclear. Coffee intake by 156 overweight subjects (87% with Type-2-Diabetes, T2D) was assessed via a questionnaire, with 98 subjects (all T2D) also providing a 24 h urine sample for quantification of coffee metabolites by LC–MS/MS. NAFLD was characterized by the fatty liver index (FLI) and by Fibroscan® assessment of fibrosis. No associations were found between self-reported coffee intake and NAFLD parameters; however, total urine caffeine metabolites, defined as Σcaffeine (caffeine + paraxanthine + theophylline), and adjusted for fat-free body mass, were significantly higher for subjects with no liver fibrosis than for those with fibrosis. Total non-caffeine metabolites, defined as Σncm (trigonelline + caffeic acid + p-coumaric acid), showed a significant negative association with the FLI. Multiple regression analyses for overweight/obese T2D subjects (n = 89) showed that both Σcaffeine and Σncm were negatively associated with the FLI, after adjusting for age, sex, HbA1c, ethanol intake and glomerular filtration rate. The theophylline fraction of Σcaffeine was significantly increased with both fibrosis and the FLI, possibly reflecting elevated CYP2E1 activity—a hallmark of NAFLD worsening. Thus, for overweight/obese T2D patients, higher intake of both caffeine and non-caffeine coffee components is associated with less severe NAFLD. Caffeine metabolites represent novel markers of NAFLD progression.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent1272795
dc.identifier.doi10.3390/nu15010004
dc.identifier.issn1422-8599
dc.identifier.otherPURE: 50629749
dc.identifier.otherPURE UUID: 4e4641cd-e2d1-49a2-abdf-483de9c9689d
dc.identifier.otherScopus: 85145936523
dc.identifier.otherPubMed: 36615664
dc.identifier.otherORCID: /0000-0002-2549-0275/work/151416321
dc.identifier.urihttp://hdl.handle.net/10362/147813
dc.identifier.urlhttps://www.scopus.com/pages/publications/85145936523
dc.language.isoeng
dc.peerreviewedyes
dc.subjectcaffeine
dc.subjectfatty liver index
dc.subjectfibrosis
dc.subjectnon-alcoholic fatty liver disease
dc.subjecttype 2 diabetes
dc.subjectFood Science
dc.subjectNutrition and Dietetics
dc.subjectSDG 3 - Good Health and Well-being
dc.titleIncreased Intake of Both Caffeine and Non-Caffeine Coffee Components Is Associated with Reduced NAFLD Severity in Subjects with Type 2 Diabetesen
dc.typejournal article
degois.publication.issue1
degois.publication.titleNutrients
degois.publication.volume15
dspace.entity.typePublication
rcaap.rightsopenAccess

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