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Design and Biocompatibility of Biodegradable Poly(octamethylene suberate) Nanoparticles to Treat Skin Diseases

2024-06-03Artigo científico Acesso aberto
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dc.contributor.authorde Barros, Dragana P.C.
dc.contributor.authorFonseca, Luís P.
dc.contributor.authorGonçalves, Luís G.
dc.contributor.authorSerrano, Diogo S.
dc.contributor.authorOliva, Abel
dc.contributor.institutionInstituto de Tecnologia Química e Biológica António Xavier (ITQB)
dc.contributor.pblMDPI AG
dc.date.accessioned2024-10-01T22:27:14Z
dc.date.available2024-10-01T22:27:14Z
dc.date.issued2024-06-03
dc.descriptionFunding Information: This work was supported by FCT\u2014Funda\u00E7\u00E3o para a Ci\u00EAncia e a Tecnologia, I.P., through iNOVA4Health (DOI 10.54499/UIDB/04462/2020; DOI 10.54499/UIDP/04462/2020) and LS4FUTURE Associated Laboratory (DOI 10.54499/LA/P/0087/2020)\u201D. Publisher Copyright: © 2024 by the authors.
dc.description.abstractBiodegradable aliphatic polyester formulations as carriers for topical drug delivery show the potential to encapsulate structurally different therapeutic compounds. Poly(octamethylene suberate) (POS) nanoparticles (POS-NPs) were used as a matrix to encapsulate four therapeutic molecules used to treat skin disorders: caffeine (CF), quercetin (QR), hydrocortisone (HC), and adapalene (AD). Hydrophobicity and chemical structure of bioactive compounds (BCs) influenced the physicochemical stability of drug-loaded nanoparticles. The particle size of drug-loaded nanoparticles was between 254.9 nm for the CF-POS-NP and 1291.3 for QR-POS-NP. Particles had a negative charge from −27.6 mV (QR) to −49.2 mV (HC). Drug loading content for all BC-POS-NPs varies between 36.11 ± 1.48% (CF-POS-NP) and 66.66 ± 4.87% (AD-POS-NP), and their entrapment efficiency is relatively high (28.30 ± 1.81% and 99.95 ± 0.04%, respectively). Calorimetric analysis showed the appearance of polymorphism for AD- and HC-loaded systems and the drug’s complete solubilisation into all nanoparticle formulations. FTIR and NMR spectra showed apparent drug incorporation into the polymer matrix of NPs. The encapsulation of BCs enhanced the antioxidative effect. The prepared POS nanoparticles’ cytotoxicity was studied using two dermal cell lines, keratinocyte (HaCaT) cells and fibroblasts (HDFn). The nanoparticle cytotoxic effect was more substantial on HaCaT cell lines. A reconstructed human epidermis (RHE) was successfully used to investigate the penetration of polymeric NPs. Based on permeation and histology studies, HC-POS-NPs and CF-POS-NPs were shown not to be suitable for dermal applications with the explored drug concentrations. AD presents a high permeation rate and no toxic impact on RHE.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent6150307
dc.identifier.doi10.3390/pharmaceutics16060753
dc.identifier.issn1999-4923
dc.identifier.otherPURE: 100056663
dc.identifier.otherPURE UUID: 173cb4d3-3ef9-41fa-b02a-992595ae7f51
dc.identifier.otherScopus: 85197116223
dc.identifier.otherORCID: /0000-0001-5683-3552/work/168642579
dc.identifier.urihttp://hdl.handle.net/10362/172815
dc.identifier.urlhttps://www.scopus.com/pages/publications/85197116223
dc.language.isoeng
dc.peerreviewedyes
dc.subjectaliphatic polyesters
dc.subjectbiocompatibility
dc.subjectdermal delivery
dc.subjectpoly(octamethylene suberate) nanoparticle
dc.subjecttherapeutic compounds
dc.subjectPharmaceutical Science
dc.titleDesign and Biocompatibility of Biodegradable Poly(octamethylene suberate) Nanoparticles to Treat Skin Diseasesen
dc.typejournal article
degois.publication.issue6
degois.publication.titlePharmaceutics
degois.publication.volume16
dspace.entity.typePublication
rcaap.rightsopenAccess

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