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Antidepressant Utilization and Suicide in Europe: An Ecological Multi-National Study

2013-06-19Artigo científico Acesso aberto
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dc.contributor.authorGusmão, Ricardo
dc.contributor.authorQuintão, Sónia
dc.contributor.authorMcDaid, David
dc.contributor.authorArensman, Ella
dc.contributor.authorVan Audenhove, Chantal
dc.contributor.authorCoffey, Claire
dc.contributor.authorVärnik, Airi
dc.contributor.authorVärnik, Peeter
dc.contributor.authorCoyne, James
dc.contributor.authorHegerl, Ulrich
dc.contributor.institutionNOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
dc.contributor.institutionCentro de Estudos de Doenças Crónicas (CEDOC)
dc.contributor.pblPLOS - Public Library of Science
dc.date.accessioned2017-08-02T22:05:10Z
dc.date.available2017-08-02T22:05:10Z
dc.date.issued2013-06-19
dc.description.abstractBackground:Research concerning the association between use of antidepressants and incidence of suicide has yielded inconsistent results and is the subject of considerable controversy. The first aim is to describe trends in the use of antidepressants and rates of suicide in Europe, adjusted for gross domestic product, alcohol consumption, unemployment, and divorce. The second aim is to explore if any observed reduction in the rate of suicide in different European countries preceded the trend for increased use of antidepressants.Methods:Data were obtained for 29 European countries between 1980 and 2009. Pearson correlations were used to explore the direction and magnitude of associations. Generalized linear mixed models and Poisson regression distribution were used to clarify the effects of antidepressants on suicide rates, while an autoregressive adjusted model was used to test the interaction between antidepressant utilization and suicide over two time periods: 1980-1994 and 1995-2009.Findings:An inverse correlation was observed in all countries between recorded Standardised Death Rate (SDR) for suicide and antidepressant Defined Daily Dosage (DDD), with the exception of Portugal. Variability was marked in the association between suicide and alcohol, unemployment and divorce, with countries depicting either a positive or a negative correlation with the SDR for suicide. Every unit increase in DDD of an antidepressant per 1000 people per day, adjusted for these confounding factors, reduces the SDR by 0.088. The correlation between DDD and suicide related SDR was negative in both time periods considered, albeit more pronounced between 1980 and 1994.Conclusions:Suicide rates have tended to decrease more in European countries where there has been a greater increase in the use of antidepressants. These findings underline the importance of the appropriate use of antidepressants as part of routine care for people diagnosed with depression, therefore reducing the risk of suicide.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent2075578
dc.identifier.doi10.1371/journal.pone.0066455
dc.identifier.issn1932-6203
dc.identifier.otherPURE: 2987377
dc.identifier.otherPURE UUID: 779a7961-4d22-404c-b8f1-effaa05b29e1
dc.identifier.otherScopus: 84879210440
dc.identifier.otherPubMed: 23840475
dc.identifier.otherWOS: 000322361200082
dc.identifier.urihttp://www.scopus.com/inward/record.url?scp=84879210440&partnerID=8YFLogxK
dc.identifier.urlhttps://www.scopus.com/pages/publications/84879210440
dc.language.isoeng
dc.peerreviewedyes
dc.subjectMENTAL-DISORDERS
dc.subjectRATES
dc.subjectPREVENTION
dc.subjectALCOHOL
dc.subjectHEALTH
dc.subjectDEPRESSION
dc.subjectCOUNTRIES
dc.subjectPATTERNS
dc.subjectBEHAVIOR
dc.subjectHUNGARY
dc.subjectGeneral Medicine
dc.subjectGeneral Biochemistry,Genetics and Molecular Biology
dc.subjectGeneral Agricultural and Biological Sciences
dc.subjectSDG 3 - Good Health and Well-being
dc.subjectSDG 8 - Decent Work and Economic Growth
dc.titleAntidepressant Utilization and Suicide in Europe: An Ecological Multi-National Studyen
dc.typejournal article
degois.publication.issue6
degois.publication.titlePLoS ONE
degois.publication.volume8
dspace.entity.typePublication
rcaap.rightsopenAccess

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