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Retention in Care and Virological Failure among Adult HIV-Positive Patients on First-Line Antiretroviral Treatment in Maputo, Mozambique

2023-10Artigo científico Acesso aberto
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dc.contributor.authorJoaquim, Leonid
dc.contributor.authorMiranda, Mafalda N. S.
dc.contributor.authorPimentel, Victor
dc.contributor.authorMartins, Maria do Rosario Oliveira
dc.contributor.authorNhampossa, Tacilta
dc.contributor.authorAbecasis, Ana
dc.contributor.authorPingarilho, Marta
dc.contributor.institutionTB, HIV and opportunistic diseases and pathogens (THOP)
dc.contributor.institutionGlobal Health and Tropical Medicine (GHTM)
dc.contributor.institutionInstituto de Higiene e Medicina Tropical (IHMT)
dc.contributor.institutionPopulation health, policies and services (PPS)
dc.contributor.pblMDPI - Multidisciplinary Digital Publishing Institute
dc.date.accessioned2024-02-08T00:17:25Z
dc.date.available2024-02-08T00:17:25Z
dc.date.issued2023-10
dc.descriptionFunding Information: This study was supported by the Mark Weinberg Fellowship program—International AIDS Society (IAS), through a grant from the FCT Integriv project (PTDC/SAU-INF/31990/2017), by FCT MARVEL (PTDC/SAU-PUB/4018/2021) and by funds from Fundação para a Ciência e Tecnologia to GHTM-UID/04413/2020 and LA-REAL-LA/P/0117/2020. Publisher Copyright: © 2023 by the authors.
dc.description.abstractIntroduction: Access to antiretroviral treatment (ART) is increasingly available worldwide; however, the number of patients lost to follow-up and number of treatment failures continue to challenge most African countries. Objectives: To analyse the retention in clinical care and the virological response and their associated factors of HIV-1 patients from the Maputo Military Hospital (MMH). Methods: A cross-sectional observational study was conducted to analyse data from patients who started ART between 2016 and 2018 in the MMH. Results: At the end of 12 months, 75.1% of 1247 patients were active on clinical follow-up and 16.8% had suspected virologic failure (VL > 1000 copies/mm3). Patients younger than 40 years old were more likely to be lost to follow-up when compared to those aged >50 years old, as well as patients who were unemployed and patients with a CD4 count < 350 cells/mm3. Patients with haemoglobin levels lower than 10 g/dL and with a CD4 count < 350 cells/mm3 were more likely to have virological failure. Conclusions: We have identified clinical and sociodemographic determinants of loss to follow-up and in the development of virological failure for HIV-positive patients in clinical care in the MMH. Therefore, HIV programs must consider these factors to increase the screening of patients at high risk of poor outcomes and particularly to strengthen adherence counselling programs.en
dc.description.versionpublished
dc.format.extent563085
dc.identifier.doi10.3390/v15101978
dc.identifier.issn1999-4915
dc.identifier.otherPURE: 82854084
dc.identifier.otherPURE UUID: aba72f77-a906-477d-be89-eeb20db99c83
dc.identifier.otherScopus: 85175200165
dc.identifier.otherPubMed: 37896757
dc.identifier.otherWOS: WOS:001099331400001
dc.identifier.otherORCID: /0000-0002-7941-0285/work/152551870
dc.identifier.urihttp://hdl.handle.net/10362/163242
dc.identifier.urlhttps://www.scopus.com/pages/publications/85175200165
dc.language.isoeng
dc.peerreviewedyes
dc.subjectHIV-1
dc.subjectMozambique
dc.subjectretention on care
dc.subjectvirological response
dc.subjectInfectious Diseases
dc.subjectVirology
dc.subjectSDG 3 - Good Health and Well-being
dc.subjectSDG 10 - Reduced Inequalities
dc.titleRetention in Care and Virological Failure among Adult HIV-Positive Patients on First-Line Antiretroviral Treatment in Maputo, Mozambiqueen
dc.typejournal article
degois.publication.issue10
degois.publication.titleViruses
degois.publication.volume15
dspace.entity.typePublication
rcaap.rightsopenAccess

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