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A predictive rheological framework to define printability of thermo-sensitive bioinks using non-temperature-controlled bioprinters

2026-04Artigo científico Acesso aberto
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dc.contributor.authorAnjos, Inês
dc.contributor.authorVieira, Tânia
dc.contributor.authorVentura, Luana
dc.contributor.authorAktar, Taslima
dc.contributor.authorCarvalho Silva, Jorge
dc.contributor.authorMendes, Bárbara B.
dc.contributor.authorConde, João
dc.contributor.authorBolaños, Luis Felipe
dc.contributor.authorFernandes, Susete
dc.contributor.authorLeal, Catarina
dc.contributor.authorBorges, João Paulo
dc.contributor.authorLimón, David
dc.contributor.institutionDF – Departamento de Física
dc.contributor.institutionDCM - Departamento de Ciência dos Materiais
dc.contributor.institutionCENIMAT-i3N - Centro de Investigação de Materiais (Lab. Associado I3N)
dc.contributor.institutionFaculdade de Ciências e Tecnologia (FCT)
dc.contributor.institutionNOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
dc.contributor.institutionComprehensive Health Research Centre (CHRC) - pólo NMS
dc.contributor.institutionUNINOVA-Instituto de Desenvolvimento de Novas Tecnologias
dc.contributor.pblElsevier
dc.date.accessioned2026-04-29T15:45:01Z
dc.date.available2026-04-29T15:45:01Z
dc.date.issued2026-04
dc.descriptionPublisher Copyright: Copyright © 2026. Published by Elsevier Ltd.
dc.description.abstract3D-bioprinting requires bioinks with a set of mechanical and chemical characteristics, including biocompatibility, suitable flow, the preservation of cell viability during extrusion, and shape retention upon printing to construct structures in 3D. Biopolymer-based hydrogels including mixtures of gelatin and alginate are ideal, although their printability is challenging due to important thermoresponsive behavior, requiring expensive temperature-controlled printers. Here, we present a methodological framework that predicts the printability of gelatin–alginate bioinks directly from rheological parameters. By quantitatively linking viscosity and storage/loss ratio to extrusion fidelity, and by identifying gelation temperature and gelation speed as key windows for adjusting the printing process, we establish actionable design rules that enable printing with non-temperature-controlled devices, resulting in shape fidelity, spreading ratios, and printability ratios close to 1, while permitting a high cell viability after printing (92.4 ± 2.2%) that can be maintained for up to 8 days (96.5 ± 0.9%). This predictive approach provides a practical pathway to design thermosensitive bioinks without relying on trial-and-error or specialized equipment, broadening the accessibility of 3D bioprinting technologies for tissue engineering.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent10640091
dc.identifier.doi10.1016/j.polymertesting.2026.109138
dc.identifier.issn0142-9418
dc.identifier.otherPURE: 161586236
dc.identifier.otherPURE UUID: 3c8dc906-72f9-4bba-a1f2-79e5937e6799
dc.identifier.otherScopus: 105032902770
dc.identifier.otherORCID: /0000-0002-3996-6545/work/213284058
dc.identifier.otherORCID: /0000-0001-9959-4272/work/213284099
dc.identifier.otherORCID: /0000-0002-7871-6717/work/213284965
dc.identifier.otherORCID: /0000-0001-8447-1886/work/213285119
dc.identifier.urihttp://hdl.handle.net/10362/202703
dc.identifier.urlhttps://www.scopus.com/pages/publications/105032902770
dc.language.isoeng
dc.peerreviewedyes
dc.subject3D bioprinting
dc.subjectBiocompatibility
dc.subjectBioinks
dc.subjectHydrogels
dc.subjectPrintability
dc.subjectRheology
dc.subjectTissue engineering
dc.subjectPolymers and Plastics
dc.subjectOrganic Chemistry
dc.titleA predictive rheological framework to define printability of thermo-sensitive bioinks using non-temperature-controlled bioprintersen
dc.typejournal article
degois.publication.titlePolymer Testing
degois.publication.volume157
dspace.entity.typePublication
rcaap.rightsopenAccess

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