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Massive introgression drives species radiation at the range limit of Anopheles gambiae

2017-04-18Artigo científico Acesso aberto
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dc.contributor.authorVicente, José L.
dc.contributor.authorClarkson, Christopher S.
dc.contributor.authorCaputo, Beniamino
dc.contributor.authorGomes, Bruno
dc.contributor.authorPombi, Marco
dc.contributor.authorSousa, Carla A.
dc.contributor.authorAntao, Tiago
dc.contributor.authorDInis, Joaõ
dc.contributor.authorBottà, Giordano
dc.contributor.authorMancini, Emiliano
dc.contributor.authorPetrarca, Vincenzo
dc.contributor.authorMead, Daniel
dc.contributor.authorDrury, Eleanor
dc.contributor.authorStalker, James
dc.contributor.authorMiles, Alistair
dc.contributor.authorKwiatkowski, Dominic P.
dc.contributor.authorDonnelly, Martin J.
dc.contributor.authorRodrigues, Amabélia
dc.contributor.authorTorre, Alessandra Della
dc.contributor.authorWeetman, David
dc.contributor.authorPinto, João
dc.contributor.institutionInstituto de Higiene e Medicina Tropical (IHMT)
dc.contributor.institutionGlobal Health and Tropical Medicine (GHTM)
dc.contributor.institutionVector borne diseases and pathogens (VBD)
dc.contributor.pblNature Publishing Group
dc.date.accessioned2018-05-10T22:13:26Z
dc.date.available2018-05-10T22:13:26Z
dc.date.issued2017-04-18
dc.description.abstractImpacts of introgressive hybridisation may range from genomic erosion and species collapse to rapid adaptation and speciation but opportunities to study these dynamics are rare. We investigated the extent, causes and consequences of a hybrid zone between Anopheles coluzzii and Anopheles gambiae in Guinea-Bissau, where high hybridisation rates appear to be stable at least since the 1990s. Anopheles gambiae was genetically partitioned into inland and coastal subpopulations, separated by a central region dominated by A. coluzzii. Surprisingly, whole genome sequencing revealed that the coastal region harbours a hybrid form characterised by an A. gambiae-like sex chromosome and massive introgression of A. coluzzii autosomal alleles. Local selection on chromosomal inversions may play a role in this process, suggesting potential for spatiotemporal stability of the coastal hybrid form and providing resilience against introgression of medically-important loci and traits, found to be more prevalent in inland A. gambiae.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent13
dc.format.extent973839
dc.identifier.doi10.1038/srep46451
dc.identifier.issn2045-2322
dc.identifier.otherPURE: 2793366
dc.identifier.otherPURE UUID: a208d0d1-529f-4489-8987-75c98d1dcf82
dc.identifier.otherScopus: 85017639499
dc.identifier.otherWOS: 000399615900001
dc.identifier.otherPubMed: 28417969
dc.identifier.otherPubMedCentral: PMC5394460
dc.identifier.otherORCID: /0000-0001-8572-7708/work/49741573
dc.identifier.urihttp://www.scopus.com/inward/record.url?scp=85017639499&partnerID=8YFLogxK
dc.identifier.urlhttps://www.scopus.com/pages/publications/85017639499
dc.language.isoeng
dc.peerreviewedyes
dc.subjectMALARIA VECTOR MOSQUITOS
dc.subjectMOLECULAR-FORMS
dc.subjectGENE-FLOW
dc.subjectINCIPIENT SPECIATION
dc.subjectPOPULATION-STRUCTURE
dc.subjectS FORMS
dc.subjectASYMMETRIC INTROGRESSION;
dc.subjectADAPTIVE INTROGRESSION;
dc.subjectINSECTICIDE RESISTANCE
dc.subjectGENOMIC DIVERGENCE
dc.subjectEcology, Evolution, Behavior and Systematics
dc.subjectInsect Science
dc.subjectInfectious Diseases
dc.subjectSDG 15 - Life on Land
dc.subjectSDG 3 - Good Health and Well-being
dc.titleMassive introgression drives species radiation at the range limit of Anopheles gambiaeen
dc.typejournal article
degois.publication.titleScientific Reports
degois.publication.volume7
dspace.entity.typePublication
rcaap.rightsopenAccess

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