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Generation and characterization of a human iPS cell line from a patient-related control to study disease mechanisms associated with DAND5 p.R152H alteration

2018-05Artigo científico Acesso aberto
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dc.contributor.authorPars, Selin
dc.contributor.authorCristo, Fernando
dc.contributor.authorInácio, José M
dc.contributor.authorRosas, Graça
dc.contributor.authorCarreira, Isabel Marques
dc.contributor.authorMelo, Joana Barbosa
dc.contributor.authorMendes, Patrícia
dc.contributor.authorMartins, Duarte Saraiva
dc.contributor.authorde Almeida, Luís Pereira
dc.contributor.authorMaio, José
dc.contributor.authorAnjos, Rui
dc.contributor.authorBelo, José A
dc.contributor.authorA. Belo, José
dc.contributor.institutionNOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
dc.contributor.institutionCentro de Estudos de Doenças Crónicas (CEDOC)
dc.contributor.pblSpringer Verlag
dc.date.accessioned2018-05-23T22:06:37Z
dc.date.available2018-05-23T22:06:37Z
dc.date.issued2018-05
dc.descriptionWe would like to thank the patient and their guardians for their generous donation of the urine sample used in this study. We also would like to thank Ana Jardim for technical support in karyotype analysis. This work was supported by Fundacao para a Ciencia e a Tecnologia (PTDC/BIM-MED/3363/2014). iNOVA4Health - UID/Multi/04462/2013, a program financially supported by Fundacao para a Ciencia e Tecnologia/Ministerio da Educacao e Ciencia, through national funds and co-funded by FEDER under the PT2020 Partnership Agreement is acknowledged.
dc.description.abstractA DAND5-control human iPSC line was generated from the urinary cells of a phenotypically normal donor. Exfoliated renal epithelial (RE) cells were collected and reprogrammed into iPSCs using Sendai virus reprogramming system. The pluripotency, in vitro differentiation potential, karyotype stability, and the transgene-free status of generated iPSC line were analyzed and confirmed. This cell line can be exploited as a control iPSC line to better understand the mechanisms involved in DAND5-associated cardiac disease.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent5
dc.format.extent3018463
dc.identifier.doi10.1016/j.scr.2018.04.015
dc.identifier.issn1873-5061
dc.identifier.otherPURE: 4163092
dc.identifier.otherPURE UUID: 52141f16-320b-4cd4-af56-05faa9694ab5
dc.identifier.otherPubMed: 29730570
dc.identifier.otherScopus: 85046774686
dc.identifier.otherWOS: 000434978900035
dc.identifier.urihttp://hdl.handle.net/10362/37756
dc.language.isoeng
dc.peerreviewedyes
dc.relationinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F81431%2F2011/PT
dc.relationinfo:eu-repo/grantAgreement/FCT/5876/147260/PT
dc.subjectSDG 3 - Good Health and Well-being
dc.titleGeneration and characterization of a human iPS cell line from a patient-related control to study disease mechanisms associated with DAND5 p.R152H alterationen
dc.typejournal article
degois.publication.firstPage202
degois.publication.lastPage206
degois.publication.titleStem Cell Research
degois.publication.volume29
dspace.entity.typePublication
oaire.awardNumberSFRH/BD/81431/2011
oaire.awardNumberUID/Multi/04462/2013
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F81431%2F2011/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FMulti%2F04462%2F2013/PT
oaire.fundingStreamSFRH
oaire.fundingStream5876
person.familyNameBelo
person.givenNameJosé A.
person.identifier.ciencia-idBF13-08E9-25E6
person.identifier.orcid0000-0001-7384-0949
person.identifier.ridF-4444-2012
person.identifier.scopus-author-id6602141392
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccess
relation.isAuthorOfPublication9f75224c-9cf2-478f-9c7c-d22527950642
relation.isAuthorOfPublication.latestForDiscovery9f75224c-9cf2-478f-9c7c-d22527950642
relation.isProjectOfPublication22a62cb9-0b99-41b7-8c70-e9177e62f774
relation.isProjectOfPublication828e3044-8984-4282-bc90-98654cc2323e
relation.isProjectOfPublication.latestForDiscovery22a62cb9-0b99-41b7-8c70-e9177e62f774

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