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Sustainable production of high-value molecules using engineered plant cultured cells

2025-11-25Tese de doutoramento Acesso embargado
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dc.contributor.advisorAbranches, Rita
dc.contributor.advisorVentura, Rita
dc.contributor.authorRebelo, Bárbara Almeida
dc.date.accessioned2026-01-19T13:59:41Z
dc.date.available2026-01-19T13:59:41Z
dc.date.issued2025-11-25
dc.date.submitted2025-08-13
dc.description.abstract"Plant cell suspension cultures offer a promising and sustainable platform for the production of high-value compounds. In this thesis, the main objective was to explore their versatility beyond recombinant protein production, focusing on the biosynthesis of secondary metabolites, particularly the commercially valuable carotenoids. Among them, ketocarotenoids such as canthaxanthin and astaxanthin are especially valued for their antioxidant properties and strong pigmentation. However, their production remains costly due to limited natural sources and complex chemical synthesis. To address this challenge, Nicotiana tabacum BY-2 cells were used as a model system to establish the workflow for both metabolic engineering and transcriptomic and phenotypic characterization.(...)"por
dc.identifier.tid101841035
dc.identifier.urihttp://hdl.handle.net/10362/199520
dc.language.isoeng
dc.relationPD/BD/149196/2019
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectbiosynthesis
dc.subjectsecondary metabolites
dc.subjectcaratenoids
dc.subjectcanthaxanthin
dc.subjectastaxanthin
dc.subjectNicotiana tabacum
dc.titleSustainable production of high-value molecules using engineered plant cultured cellseng
dc.typedoctoral thesis
dspace.entity.typePublication
thesis.degree.nameDoutoramento em Biologia de Plantas-Plantas para a Vida

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ITQB: PCB - PhD Theses