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Clinical outcomes of dengue patients requiring intensive care in Brazil

2027-02Artigo científico Acesso aberto
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dc.contributor.authorAzevedo, Luciano Cesar Pontes
dc.contributor.authorSiqueira, Marina Martins
dc.contributor.authorCorrea, Lucas Hernandes
dc.contributor.authorPitrowsky, Melissa Tassano
dc.contributor.authorBorges, Lunna Perdigao
dc.contributor.authorSalluh, Milla Fuks
dc.contributor.authorFonseca, Henrique Andrade R.
dc.contributor.authorSoares, Marcio
dc.contributor.authorSalluh, Jorge Ibrain Figueira
dc.contributor.institutionNOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
dc.contributor.institutionComprehensive Health Research Centre (CHRC) - pólo NMS
dc.contributor.pblElsevier
dc.date.accessioned2026-09-08T14:43:01Z
dc.date.available2026-09-08T14:43:01Z
dc.date.issued2027-02
dc.descriptionPublisher Copyright: © 2026 The Authors.
dc.description.abstractBackground Dengue may lead to critical illness requiring intensive care unit (ICU) admission. Even though Brazil is one of the most affected countries worldwide, national data are limited. Understanding clinical severity and outcomes is essential to inform policy and preparedness. Methods We conducted a retrospective study of adult dengue ICU admissions in Brazil from 2015 to 2024 using aggregated data from two nationwide complementary datasets: the Brazilian ICU registry (UTIs Brasileiras) and DATASUS Hospital Information System. The registry dataset includes clinical, severity, and organ-support variables from public and private institutions, while DATASUS captures public-system (SUS) reimbursed hospitalizations. Outcomes were ICU and in-hospital mortality, organ support, and length of stay. Results We identified 32,016 episodes of dengue admissions in the ICU registry and 11,241 in DATASUS. Data from the registry for the first 24 h of ICU shows mechanical ventilation use in 5.8% and vasopressors use in 7.2%. In-hospital mortality was 8.2% in the ICU registry. In DATASUS, in-hospital mortality was 18.6%. Patients admitted to public hospitals in the ICU registry had unadjusted ICU mortality of 20% and in-hospital mortality of 25%. Unadjusted mortality rates were higher in subgroups like older patients and those in use of vasopressors. Conclusion: Dengue requiring ICU admission in Brazil is associated with significant morbimortality. Mortality rates were higher in subgroups such as old patients and those admitted to public hospitals. Further studies are necessary to identify the potentially modifiable, organizational and patient-level factors associated with outcomes.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent777980
dc.identifier.doi10.1016/j.jcrc.2026.155734
dc.identifier.issn0883-9441
dc.identifier.otherPURE: 172432224
dc.identifier.otherPURE UUID: a63fb7e2-4768-4fa7-bff3-947697878601
dc.identifier.otherScopus: 105048551847
dc.identifier.urihttp://hdl.handle.net/10362/206183
dc.identifier.urlhttps://www.scopus.com/pages/publications/105048551847
dc.language.isoeng
dc.peerreviewedyes
dc.subjectArboviruses
dc.subjectCritical care
dc.subjectDengue
dc.subjectIntensive care unit
dc.subjectCritical Care and Intensive Care Medicine
dc.subjectSDG 3 - Good Health and Well-being
dc.titleClinical outcomes of dengue patients requiring intensive care in Brazilen
dc.title.subtitleA 10-year nationwide observational studyen
dc.typejournal article
degois.publication.titleJournal of Critical Care
degois.publication.volume97
dspace.entity.typePublication
rcaap.rightsopenAccess

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