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Mucosal leishmaniasis caused by leishmania (Viannia) braziliensis and Leishmania (Viannia) guyanensis in the Brazilian Amazon

2011-03Artigo científico Acesso aberto
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dc.contributor.authorde Oliveira Guerra, Jorge Augusto
dc.contributor.authorPrestes, Suzane Ribeiro
dc.contributor.authorSilveira, Henrique
dc.contributor.authorCoelho, Leila Inês de Aguiar Raposo Câmara
dc.contributor.authorGama, Pricila
dc.contributor.authorMoura, Aristoteles
dc.contributor.authorAmato, Valdir
dc.contributor.authorBarbosa, Marias das Graças Vale
dc.contributor.authorde Lima Ferreira, Luiz Carlos
dc.contributor.institutionInstituto de Higiene e Medicina Tropical (IHMT)
dc.contributor.institutionCentro de Malária e outras Doenças Tropicais (CMDT)
dc.contributor.pblPLOS - Public Library of Science
dc.date.accessioned2021-05-05T23:25:35Z
dc.date.available2021-05-05T23:25:35Z
dc.date.issued2011-03
dc.description.abstractBackground: Leishmania (Viannia) braziliensis is a parasite recognized as the most important etiologic agent of mucosal leishmaniasis (ML) in the New World. In Amazonia, seven different species of Leishmania, etiologic agents of human Cutaneous Leishmaniasis, have been described. Isolated cases of ML have been described for several different species of Leishmania: L. (V.) panamensis, L. (V.) guyanensis and L. (L.) amazonensis. Methodology: Leishmania species were characterized by polymerase chain reaction (PCR) of tissues taken from mucosal biopsies of Amazonian patients who were diagnosed with ML and treated at the Tropical Medicine Foundation of Amazonas (FMTAM) in Manaus, Amazonas state, Brazil. Samples were obtained retrospectively from the pathology laboratory and prospectively from patients attending the aforementioned tertiary care unit. Results: This study reports 46 cases of ML along with their geographical origin, 30 cases caused by L. (V.) braziliensis and 16 cases by L. (V.) guyanensis. This is the first record of ML cases in 16 different municipalities in the state of Amazonas and of simultaneous detection of both species in 4 municipalities of this state. It is also the first record of ML caused by L. (V.) guyanensis in the states of Pará, Acre, and Rondônia and cases of ML caused by L. (V.) braziliensis in the state of Rondônia. Conclusions/Significance: L. (V.) braziliensis is the predominant species that causes ML in the Amazon region. However, contrary to previous studies, L. (V.) guyanensis is also a significant causative agent of ML within the region. The clinical and epidemiological expression of ML in the Manaus region is similar to the rest of the country, although the majority of ML cases are found south of the Amazon River.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent473232
dc.identifier.doi10.1371/journal.pntd.0000980
dc.identifier.issn1935-2727
dc.identifier.otherPURE: 26756054
dc.identifier.otherPURE UUID: be7eceba-f85f-4fe1-a485-ffc59ef55092
dc.identifier.otherScopus: 79953779053
dc.identifier.otherPubMed: 21408116
dc.identifier.otherWOS: 000288940800014
dc.identifier.otherORCID: /0000-0002-7939-772X/work/84883117
dc.identifier.urihttp://hdl.handle.net/10362/117144
dc.identifier.urlhttps://www.scopus.com/pages/publications/79953779053
dc.language.isoeng
dc.peerreviewedyes
dc.subjectInfectious Diseases
dc.subjectParasitology
dc.subjectGenetics
dc.subjectSDG 3 - Good Health and Well-being
dc.titleMucosal leishmaniasis caused by leishmania (Viannia) braziliensis and Leishmania (Viannia) guyanensis in the Brazilian Amazonen
dc.typejournal article
degois.publication.issue3
degois.publication.titlePLoS Neglected Tropical Diseases
degois.publication.volume5
dspace.entity.typePublication
rcaap.rightsopenAccess

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