Logo do repositório
 
Publicação

Blood Pressure Regulation by the Carotid Sinus Nerve

2022-01-10Artigo científico Acesso aberto
Ver registo simples
dc.contributor.authorConde, Silvia V.
dc.contributor.authorV Conde, Silvia
dc.contributor.authorSacramento, Joana F.
dc.contributor.authorMelo, Bernardete F.
dc.contributor.authorFonseca-Pinto, Rui
dc.contributor.authorRomero-Ortega, Mario I.
dc.contributor.authorGuarino, Maria P.
dc.contributor.institutionNOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
dc.contributor.institutionCentro de Estudos de Doenças Crónicas (CEDOC)
dc.contributor.pblFrontiers Media
dc.date.accessioned2022-02-07T23:23:12Z
dc.date.available2022-02-07T23:23:12Z
dc.date.issued2022-01-10
dc.descriptionFunding Information: This study was partially supported by the GlaxoSmithKline Bioelectronics R&D ?Innovation Challenge. JS and BM were supported by a contract and a Ph.D. Grant from the Portuguese Foundation for Science and Technology Reference CEECIND/02428/2018 and PD/BD/128336/2017, respectively. This study received funding from the Fundação para a Ciência e Tecnologia (FCT) (UIDB/05704/2020).
dc.description.abstractChronic carotid sinus nerve (CSN) electrical modulation through kilohertz frequency alternating current improves metabolic control in rat models of type 2 diabetes, underpinning the potential of bioelectronic modulation of the CSN as a therapeutic modality for metabolic diseases in humans. The CSN carries sensory information from the carotid bodies, peripheral chemoreceptor organs that respond to changes in blood biochemical modifications such as hypoxia, hypercapnia, acidosis, and hyperinsulinemia. In addition, the CSN also delivers information from carotid sinus baroreceptors—mechanoreceptor sensory neurons directly involved in the control of blood pressure—to the central nervous system. The interaction between these powerful reflex systems—chemoreflex and baroreflex—whose sensory receptors are in anatomical proximity, may be regarded as a drawback to the development of selective bioelectronic tools to modulate the CSN. Herein we aimed to disclose CSN influence on cardiovascular regulation, particularly under hypoxic conditions, and we tested the hypothesis that neuromodulation of the CSN, either by electrical stimuli or surgical means, does not significantly impact blood pressure. Experiments were performed in Wistar rats aged 10–12 weeks. No significant effects of acute hypoxia were observed in systolic or diastolic blood pressure or heart rate although there was a significant activation of the cardiac sympathetic nervous system. We conclude that chemoreceptor activation by hypoxia leads to an expected increase in sympathetic activity accompanied by compensatory regional mechanisms that assure blood flow to regional beds and maintenance of hemodynamic homeostasis. Upon surgical denervation or electrical block of the CSN, the increase in cardiac sympathetic nervous system activity in response to hypoxia was lost, and there were no significant changes in blood pressure in comparison to control animals. We conclude that the responses to hypoxia and vasomotor control short-term regulation of blood pressure are dissociated in terms of hypoxic response but integrated to generate an effector response to a given change in arterial pressure.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent4155404
dc.identifier.doi10.3389/fnins.2021.725751
dc.identifier.issn1662-4548
dc.identifier.otherPURE: 36488498
dc.identifier.otherPURE UUID: 42f546b5-cbbd-48f2-865d-2458580d33b0
dc.identifier.otherScopus: 85123352395
dc.identifier.otherPubMed: 35082593
dc.identifier.otherORCID: /0000-0002-5920-5700/work/111135971
dc.identifier.otherWOS: 000757361600001
dc.identifier.urihttp://hdl.handle.net/10362/132453
dc.identifier.urlhttps://www.scopus.com/pages/publications/85123352395
dc.language.isoeng
dc.peerreviewedyes
dc.subjectblood pressure
dc.subjectcarotid body
dc.subjectcarotid sinus nerve
dc.subjecthypoxia
dc.subjectneuromodulation
dc.subjectGeneral Neuroscience
dc.subjectSDG 3 - Good Health and Well-being
dc.titleBlood Pressure Regulation by the Carotid Sinus Nerveen
dc.title.subtitleClinical Implications for Carotid Body Neuromodulationen
dc.typejournal article
degois.publication.titleFrontiers in Neuroscience
degois.publication.volume15
dspace.entity.typePublication
person.familyNameVilares Conde
person.givenNameSilvia
person.identifier154176
person.identifier.ciencia-id561E-CF29-600A
person.identifier.orcid0000-0002-5920-5700
person.identifier.scopus-author-id7004283202
rcaap.rightsopenAccess
relation.isAuthorOfPublication898e99d8-61a5-44bc-878a-5e1ac44ca37c
relation.isAuthorOfPublication.latestForDiscovery898e99d8-61a5-44bc-878a-5e1ac44ca37c

Ficheiros

Principais
A mostrar 1 - 1 de 1
Miniatura
Nome:
fnins_15_725751.pdf
Tamanho:
3.96 MB
Formato:
Adobe Portable Document Format
Ver/Abrir

Coleções

NMS: CEDOC - Artigos em revista internacional com arbitragem científica