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Health-related quality of life in older patients surviving ICU treatment for COVID-19

2022-02-02Artigo científico Acesso aberto
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dc.contributor.authorSoliman, Ivo W
dc.contributor.authorLeaver, Susannah
dc.contributor.authorFlaatten, Hans
dc.contributor.authorFjølner, Jesper
dc.contributor.authorWernly, Bernhard
dc.contributor.authorBruno, Raphael R
dc.contributor.authorArtigas, Antonio
dc.contributor.authorBollen Pinto, Bernardo
dc.contributor.authorSchefold, Joerg C
dc.contributor.authorBeil, Michael
dc.contributor.authorSviri, Sigal
dc.contributor.authorvan Heerden, Peter Vernon
dc.contributor.authorSzczeklik, Wojciech
dc.contributor.authorElhadi, Muhammed
dc.contributor.authorJoannidis, Michael
dc.contributor.authorOeyen, Sandra
dc.contributor.authorZafeiridis, Tilemachos
dc.contributor.authorZafeiridis, Tilemachos
dc.contributor.authorWollborn, Jakob
dc.contributor.authorBanzo, Maria Jose Arche
dc.contributor.authorFuest, Kristina
dc.contributor.authorMarsh, Brian
dc.contributor.authorAndersen, Finn H
dc.contributor.authorMoreno, Rui
dc.contributor.authorBoumendil, Ariane
dc.contributor.authorGuidet, Bertrand
dc.contributor.authorJung, Christian
dc.contributor.authorDe Lange, Dylan W
dc.contributor.institutionNOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
dc.contributor.pblOxford University Press
dc.date.accessioned2022-02-24T23:23:09Z
dc.date.available2022-02-24T23:23:09Z
dc.date.issued2022-02-02
dc.descriptionFunding: In addition, the study was supported by a grant from the European Open Science Cloud (EOSC). EOSCsecretariat.eu has received funding from the European Union’s Horizon Programme call H2020-INFRAEOSC-05-2018-2019, grant agreement number 831644. This work was supported by the Forschungskommission of the Medical Faculty of the Heinrich-Heine-University Düsseldorf, No. 2018-32 to G.W. and No. 2020-21 to R.R.B. for a Clinician Scientist Track.
dc.description.abstractBACKGROUND: health-related quality of life (HRQoL) is an important patient-centred outcome in patients surviving ICU admission for COVID-19. It is currently not clear which domains of the HRQoL are most affected. OBJECTIVE: to quantify HRQoL in order to identify areas of interventions. DESIGN: prospective observation study. SETTING: admissions to European ICUs between March 2020 and February 2021. SUBJECTS: patients aged 70 years or older admitted with COVID-19 disease. METHODS: collected determinants include SOFA-score, Clinical Frailty Scale (CFS), number and timing of ICU procedures and limitation of care, Katz Activities of Daily Living (ADL) dependence score. HRQoL was assessed at 3 months after ICU admission with the Euro-QoL-5D-5L questionnaire. An outcome of ≥4 on any of Euro-QoL-5D-5L domains was considered unfavourable. RESULTS: in total 3,140 patients from 14 European countries were included in this study. Three months after inclusion, 1,224 patients (39.0%) were alive and the EQ-5D-5L from was obtained. The CFS was associated with an increased odds ratio for an unfavourable HRQoL outcome after 3 months; OR 1.15 (95% confidence interval (CI): 0.71-1.87) for CFS 2 to OR 4.33 (95% CI: 1.57-11.9) for CFS ≧ 7. The Katz ADL was not statistically significantly associated with HRQoL after 3 months. CONCLUSIONS: in critically ill old intensive care patients suffering from COVID-19, the CFS is associated with the subjectively perceived quality of life. The CFS on admission can be used to inform patients and relatives on the risk of an unfavourable qualitative outcome if such patients survive.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent503147
dc.identifier.doi10.1093/ageing/afab278
dc.identifier.issn0002-0729
dc.identifier.otherPURE: 41813478
dc.identifier.otherPURE UUID: 611b81e7-24a9-4086-a1e2-4469a245ddb9
dc.identifier.otherPubMed: 35136896
dc.identifier.otherPubMedCentral: PMC8825757
dc.identifier.otherScopus: 85124266277
dc.identifier.otherWOS: 000753116600003
dc.identifier.urihttp://hdl.handle.net/10362/133568
dc.language.isoeng
dc.peerreviewedyes
dc.titleHealth-related quality of life in older patients surviving ICU treatment for COVID-19en
dc.title.subtitleresults from an international observational study of patients older than 70 yearsen
dc.typejournal article
degois.publication.issue2
degois.publication.titleAge And Ageing
degois.publication.volume51
dspace.entity.typePublication
person.familyNameZafeiridis
person.givenNameTilemachos
person.identifier.orcid0000-0001-5020-312X
rcaap.rightsopenAccess
relation.isAuthorOfPublication238e23ee-a9f7-42ef-8d52-6141abcebafe
relation.isAuthorOfPublication.latestForDiscovery238e23ee-a9f7-42ef-8d52-6141abcebafe

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