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Potential causal association between gut microbiome and posttraumatic stress disorder

2024-01-31Artigo científico Acesso aberto
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dc.contributor.authorHe, Qiang
dc.contributor.authorWang, Wenjing
dc.contributor.authorXu, Dingkang
dc.contributor.authorXiong, Yang
dc.contributor.authorTao, Chuanyuan
dc.contributor.authorYou, Chao
dc.contributor.authorMa, Lu
dc.contributor.authorMa, Junpeng
dc.contributor.authorNievergelt, Caroline M.
dc.contributor.authorMaihofer, Adam X.
dc.contributor.authorKlengel, Torsten
dc.contributor.authorAtkinson, Elizabeth G.
dc.contributor.authorChen, Chia Yen
dc.contributor.authorChoi, Karmel W.
dc.contributor.authorColeman, Jonathan R.I.
dc.contributor.authorDalvie, Shareefa
dc.contributor.authorDuncan, Laramie E.
dc.contributor.authorLogue, Mark W.
dc.contributor.authorProvost, Allison C.
dc.contributor.authorRatanatharathorn, Andrew
dc.contributor.authorStein, Murray B.
dc.contributor.authorTorres, Katy
dc.contributor.authorAiello, Allison E.
dc.contributor.authorAlmli, Lynn M.
dc.contributor.authorAmstadter, Ananda B.
dc.contributor.authorAndersen, Søren B.
dc.contributor.authorAndreassen, Ole A.
dc.contributor.authorArbisi, Paul A.
dc.contributor.authorAshley-Koch, Allison E.
dc.contributor.authorAustin, S. Bryn
dc.contributor.authorAvdibegovic, Esmina
dc.contributor.authorBabić, Dragan
dc.contributor.authorBækvad-Hansen, Marie
dc.contributor.authorBaker, Dewleen G.
dc.contributor.authorBeckham, Jean C.
dc.contributor.authorBierut, Laura J.
dc.contributor.authorBisson, Jonathan I.
dc.contributor.authorBoks, Marco P.
dc.contributor.authorBolger, Elizabeth A.
dc.contributor.authorBørglum, Anders D.
dc.contributor.authorBradley, Bekh
dc.contributor.authorBrashear, Megan
dc.contributor.authorBreen, Gerome
dc.contributor.authorBryant, Richard A.
dc.contributor.authorBustamante, Angela C.
dc.contributor.authorBybjerg-Grauholm, Jonas
dc.contributor.authorCalabrese, Joseph R.
dc.contributor.authorJM, Caldas-de-Almeida
dc.contributor.authorCaldas-de-Almeida, José M.
dc.contributor.authorDale, Anders M.
dc.contributor.authorDaly, Mark J.
dc.contributor.authorDaskalakis, Nikolaos P.
dc.contributor.authorDeckert, Jürgen
dc.contributor.authorDelahanty, Douglas L.
dc.contributor.authorDennis, Michelle F.
dc.contributor.authorDisner, Seth G.
dc.contributor.authorDomschke, Katharina
dc.contributor.authorDzubur-Kulenovic, Alma
dc.contributor.authorErbes, Christopher R.
dc.contributor.authorEvans, Alexandra
dc.contributor.authorFarrer, Lindsay A.
dc.contributor.authorFeeny, Norah C.
dc.contributor.authorFlory, Janine D.
dc.contributor.authorForbes, David
dc.contributor.authorFranz, Carol E.
dc.contributor.authorGalea, Sandro
dc.contributor.authorGarrett, Melanie E.
dc.contributor.authorGelaye, Bizu
dc.contributor.authorGelernter, Joel
dc.contributor.authorGeuze, Elbert
dc.contributor.authorGillespie, Charles
dc.contributor.authorUka, Aferdita Goci
dc.contributor.authorGordon, Scott D.
dc.contributor.authorGuffanti, Guia
dc.contributor.authorHammamieh, Rasha
dc.contributor.authorHarnal, Supriya
dc.contributor.authorHauser, Michael A.
dc.contributor.authorHeath, Andrew C.
dc.contributor.authorHemmings, Sian M.J.
dc.contributor.authorHougaard, David Michael
dc.contributor.authorJakovljevic, Miro
dc.contributor.authorJett, Marti
dc.contributor.authorJohnson, Eric Otto
dc.contributor.authorJones, Ian
dc.contributor.authorJovanovic, Tanja
dc.contributor.authorQin, Xue Jun
dc.contributor.authorJunglen, Angela G.
dc.contributor.authorKarstoft, Karen Inge
dc.contributor.authorKaufman, Milissa L.
dc.contributor.authorKessler, Ronald C.
dc.contributor.authorKhan, Alaptagin
dc.contributor.authorKimbrel, Nathan A.
dc.contributor.authorKing, Anthony P.
dc.contributor.authorKessler, Ronald
dc.contributor.authorKoen, Nastassja
dc.contributor.authorKranzler, Henry R.
dc.contributor.authorKremen, William S.
dc.contributor.authorLawford, Bruce R.
dc.contributor.authorLebois, Lauren A.M.
dc.contributor.authorLewis, Catrin E.
dc.contributor.authorLinnstaedt, Sarah D.
dc.contributor.authorLori, Adriana
dc.contributor.authorLugonja, Bozo
dc.contributor.authorLuykx, Jurjen J.
dc.contributor.authorLyons, Michael J.
dc.contributor.authorMaples-Keller, Jessica
dc.contributor.authorMarmar, Charles
dc.contributor.authorMartin, Alicia R.
dc.contributor.authorMartin, Nicholas G.
dc.contributor.authorMaurer, Douglas
dc.contributor.authorMavissakalian, Matig R.
dc.contributor.authorMcFarlane, Alexander
dc.contributor.authorMcGlinchey, Regina E.
dc.contributor.authorMcLaughlin, Katie A.
dc.contributor.authorMcLean, Samuel A.
dc.contributor.authorMcLeay, Sarah
dc.contributor.authorMehta, Divya
dc.contributor.authorMilberg, William P.
dc.contributor.authorMiller, Mark W.
dc.contributor.authorMorey, Rajendra A.
dc.contributor.authorMorris, Charles Phillip
dc.contributor.authorMors, Ole
dc.contributor.authorMortensen, Preben B.
dc.contributor.authorNeale, Benjamin M.
dc.contributor.authorNelson, Elliot C.
dc.contributor.authorNordentoft, Merete
dc.contributor.authorNorman, Sonya B.
dc.contributor.authorO’Donnell, Meaghan
dc.contributor.authorOrcutt, Holly K.
dc.contributor.authorPanizzon, Matthew S.
dc.contributor.authorPeters, Edward S.
dc.contributor.authorPeterson, Alan L.
dc.contributor.authorPeverill, Matthew
dc.contributor.authorPietrzak, Robert H.
dc.contributor.authorPolusny, Melissa A.
dc.contributor.authorRice, John P.
dc.contributor.authorRipke, Stephan
dc.contributor.authorRisbrough, Victoria B.
dc.contributor.authorRoberts, Andrea L.
dc.contributor.authorRothbaum, Alex O.
dc.contributor.authorRothbaum, Barbara O.
dc.contributor.authorRoy-Byrne, Peter
dc.contributor.authorRuggiero, Ken
dc.contributor.authorRung, Ariane
dc.contributor.authorRutten, Bart P.F.
dc.contributor.authorSaccone, Nancy L.
dc.contributor.authorSanchez, Sixto E.
dc.contributor.authorSchijven, Dick
dc.contributor.authorSeedat, Soraya
dc.contributor.authorSeligowski, Antonia V.
dc.contributor.authorSeng, Julia S.
dc.contributor.authorSheerin, Christina M.
dc.contributor.authorSilove, Derrick
dc.contributor.authorSmith, Alicia K.
dc.contributor.authorSmoller, Jordan W.
dc.contributor.authorSolovieff, Nadia
dc.contributor.authorSponheim, Scott R.
dc.contributor.authorStein, Dan J.
dc.contributor.authorSumner, Jennifer A.
dc.contributor.authorTeicher, Martin H.
dc.contributor.authorThompson, Wesley K.
dc.contributor.authorTrapido, Edward
dc.contributor.authorUddin, Monica
dc.contributor.authorUrsano, Robert J.
dc.contributor.authorvan den Heuvel, Leigh Luella
dc.contributor.authorvan Hooff, Miranda
dc.contributor.authorVermetten, Eric
dc.contributor.authorVinkers, Christiaan H.
dc.contributor.authorVoisey, Joanne
dc.contributor.authorWang, Yunpeng
dc.contributor.authorWang, Zhewu
dc.contributor.authorWerge, Thomas
dc.contributor.authorWilliams, Michelle A.
dc.contributor.authorWilliamson, Douglas E.
dc.contributor.authorWinternitz, Sherry
dc.contributor.authorWolf, Christiane
dc.contributor.authorWolf, Erika J.
dc.contributor.authorWolff, Jonathan D.
dc.contributor.authorYehuda, Rachel
dc.contributor.authorYoung, Keith A.
dc.contributor.authorYoung, Ross Mc D.
dc.contributor.authorZhao, Hongyu
dc.contributor.authorZoellner, Lori A.
dc.contributor.authorLiberzon, Israel
dc.contributor.authorRessler, Kerry J.
dc.contributor.authorHaas, Magali
dc.contributor.authorKoenen, Karestan C.
dc.contributor.institutionNOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
dc.contributor.pblSpringer Nature
dc.date.accessioned2024-02-22T00:11:40Z
dc.date.available2024-02-22T00:11:40Z
dc.date.issued2024-01-31
dc.descriptionFunding Information: We thank the participants and working staff including the Psychiatric Genomics Consortium Posttraumatic Stress Disorder Working Group, the FinnGen consortium, and the MiBioGen consortium. Publisher Copyright: © 2024, The Author(s).
dc.description.abstractBackground: The causal effects of gut microbiome and the development of posttraumatic stress disorder (PTSD) are still unknown. This study aimed to clarify their potential causal association using mendelian randomization (MR). Methods: The summary-level statistics for gut microbiome were retrieved from a genome-wide association study (GWAS) of the MiBioGen consortium. As to PTSD, the Freeze 2 datasets were originated from the Psychiatric Genomics Consortium Posttraumatic Stress Disorder Working Group (PGC-PTSD), and the replicated datasets were obtained from FinnGen consortium. Single nucleotide polymorphisms meeting MR assumptions were selected as instrumental variables. The inverse variance weighting (IVW) method was employed as the main approach, supplemented by sensitivity analyses to evaluate potential pleiotropy and heterogeneity and ensure the robustness of the MR results. We also performed reverse MR analyses to explore PTSD’s causal effects on the relative abundances of specific features of the gut microbiome. Results: In Freeze 2 datasets from PGC-PTSD, eight bacterial traits revealed a potential causal association between gut microbiome and PTSD (IVW, all P < 0.05). In addition, Genus.Dorea and genus.Sellimonas were replicated in FinnGen datasets, in which eight bacterial traits revealed a potential causal association between gut microbiome and the occurrence of PTSD. The heterogeneity and pleiotropy analyses further supported the robustness of the IVW findings, providing additional evidence for their reliability. Conclusion: Our study provides the potential causal impact of gut microbiomes on the development of PTSD, shedding new light on the understanding of the dysfunctional gut-brain axis in this disorder. Our findings present novel evidence and call for investigations to confirm the association between their links, as well as to illuminate the underlying mechanisms.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent3162799
dc.identifier.doi10.1038/s41398-024-02765-7
dc.identifier.issn2158-3188
dc.identifier.otherPURE: 83869053
dc.identifier.otherPURE UUID: d72bee1d-1c5a-4c8b-ae1e-f268c27453d2
dc.identifier.otherScopus: 85184147737
dc.identifier.otherPubMed: 38296956
dc.identifier.urihttp://hdl.handle.net/10362/163915
dc.identifier.urlhttps://www.scopus.com/pages/publications/85184147737
dc.language.isoeng
dc.peerreviewedyes
dc.subjectPsychiatry and Mental health
dc.subjectCellular and Molecular Neuroscience
dc.subjectBiological Psychiatry
dc.subjectSDG 3 - Good Health and Well-being
dc.titlePotential causal association between gut microbiome and posttraumatic stress disorderen
dc.typejournal article
degois.publication.issue1
degois.publication.titleTranslational Psychiatry
degois.publication.volume14
dspace.entity.typePublication
person.familyNamecaldas de almeida
person.familyNameKessler
person.givenNamejosé miguel
person.givenNameRonald
person.identifier.ciencia-idA217-C270-9BA2
person.identifier.orcid0000-0003-1902-6772
person.identifier.orcid0000-0003-4831-2305
person.identifier.scopus-author-id6506787166
rcaap.rightsopenAccess
relation.isAuthorOfPublicationb48afbbc-5703-4b0f-8c88-6beb5432d327
relation.isAuthorOfPublication6c1a1bfc-ebea-4ec9-9e0b-ee83533fa86f
relation.isAuthorOfPublication.latestForDiscoveryb48afbbc-5703-4b0f-8c88-6beb5432d327

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